Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Silvia Goldoni"'
Autor:
Ye Wang, Morvarid Mohseni, Angelo Grauel, Javier Estrada Diez, Wei Guan, Simon Liang, Jiyoung Elizabeth Choi, Minying Pu, Dongshu Chen, Tyler Laszewski, Stephanie Schwartz, Jane Gu, Leandra Mansur, Tyler Burks, Lauren Brodeur, Roberto Velazquez, Steve Kovats, Bhavesh Pant, Giri Buruzula, Emily Deng, Julie T. Chen, Farid Sari-Sarraf, Christina Dornelas, Malini Varadarajan, Haiyan Yu, Chen Liu, Joanne Lim, Huai-Xiang Hao, Xiaomo Jiang, Anthony Malamas, Matthew J. LaMarche, Felipe Correa Geyer, Margaret McLaughlin, Carlotta Costa, Joel Wagner, David Ruddy, Pushpa Jayaraman, Nathaniel D. Kirkpatrick, Pu Zhang, Oleg Iartchouk, Kimberly Aardalen, Viviana Cremasco, Glenn Dranoff, Jeffrey A. Engelman, Serena Silver, Hongyun Wang, William D. Hastings, Silvia Goldoni
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-23 (2021)
Abstract SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allosteric SHP2 inhibitors promoted a
Externí odkaz:
https://doaj.org/article/aeca1d5b6b344aeabcc21b726ae4f617
Autor:
Edward Carter, Gabriela Miron-Buchacra, Silvia Goldoni, Henry Danahay, John Westwick, Malcolm L Watson, David Tosh, Stephen G Ward
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113555 (2014)
Branching morphogenesis is a critical step in the development of many epithelial organs. The phosphoinositide-3-kinase (PI3K) pathway has been identified as a central component of this process but the precise role has not been fully established. Here
Externí odkaz:
https://doaj.org/article/38d6a95452a54b9ca5345eb99a33bc87
Autor:
Morvarid Mohseni, Silvia Goldoni, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Darrin D. Stuart, Giordano Caponigro, Serena J. Silver, Susan Moody, Matthew J. LaMarche, Ali Farsidjani, LeighAnn Alexander, Michael Fleming, Joanne Lim, Minying Pu, Matthew J. Meyer, Matthew Shirley, Bhavesh Pant, Hengyu Lu, Roberto Velazquez, Steven Kovats, Chen Liu, Hongyun Wang, Huai-Xiang Hao
Supplementary Table 4: List of cell lines evaluated for sensitivity to SHP099 (Tab 1) or an RTK-inhibitor (Tab 2) in 2D or 3D. Included is the lineage and the KRAS mutation status. Where data are blank, no viable data was available, or the cell line
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f49ad0e25c2219927d12003d243a912
https://doi.org/10.1158/1535-7163.22505907
https://doi.org/10.1158/1535-7163.22505907
Autor:
Morvarid Mohseni, Silvia Goldoni, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Darrin D. Stuart, Giordano Caponigro, Serena J. Silver, Susan Moody, Matthew J. LaMarche, Ali Farsidjani, LeighAnn Alexander, Michael Fleming, Joanne Lim, Minying Pu, Matthew J. Meyer, Matthew Shirley, Bhavesh Pant, Hengyu Lu, Roberto Velazquez, Steven Kovats, Chen Liu, Hongyun Wang, Huai-Xiang Hao
In vivo efficacy of SHP099 (100 mg/kg, daily) in the KYSE-520 esophageal cancer cell line model. Data are plotted as the treatment mean {plus minus} s.e.m (n=7) ( (B-I) In vivo efficacy data for cell line models represented in Fig. 3E. SHP099 and tra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e23a96a9d6967e72861ff793ea06ac6
https://doi.org/10.1158/1535-7163.22505931
https://doi.org/10.1158/1535-7163.22505931
Autor:
Morvarid Mohseni, Silvia Goldoni, Jeffrey A. Engelman, Juliet Williams, Peter S. Hammerman, Tinya J. Abrams, Darrin D. Stuart, Giordano Caponigro, Serena J. Silver, Susan Moody, Matthew J. LaMarche, Ali Farsidjani, LeighAnn Alexander, Michael Fleming, Joanne Lim, Minying Pu, Matthew J. Meyer, Matthew Shirley, Bhavesh Pant, Hengyu Lu, Roberto Velazquez, Steven Kovats, Chen Liu, Hongyun Wang, Huai-Xiang Hao
Supplementary Material and Methods. File contains the following: Transcriptome sequencing and analysis, Soft agar assay, 2D and 3D Cell proliferation screen and compound characterization information.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d0866bef518d87af5ce97aa1cbfb0d
https://doi.org/10.1158/1535-7163.22505919.v1
https://doi.org/10.1158/1535-7163.22505919.v1
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
CSF1R-driven SHP2-dependent MAPK signaling in GDM-1 cells and SHP2 dependency of the viability in M-CSF-stimulated monocytes in the T cell co-culture assay, and the in vivo combination benefit in suppressing tumor associated macrophage by anti-PD-1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06731a1fc427831477507d6aebca12e0
https://doi.org/10.1158/1078-0432.22478133
https://doi.org/10.1158/1078-0432.22478133
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4250d56edcf37820adc098681f1006
https://doi.org/10.1158/1078-0432.22478130
https://doi.org/10.1158/1078-0432.22478130
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
The synergy in the MAPK pathway suppression and anti-proliferation effect by KRASG12C inhibitor and TNO155.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::013172c44043cee447214f4abb7b9e85
https://doi.org/10.1158/1078-0432.22478136.v1
https://doi.org/10.1158/1078-0432.22478136.v1
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
Identification of the feedback activated RTK and the synergy in anti-proliferation effect by the combination of respective RTK inhibitors and dabrafenib plus trametinib in RKO and MDST8 cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e7cb8da75cd0e34edbe53dd9cde73d8
https://doi.org/10.1158/1078-0432.22478139
https://doi.org/10.1158/1078-0432.22478139
Autor:
Huai-Xiang Hao, Giordano Caponigro, Morvarid Mohseni, Tinya J. Abrams, Peter S. Hammerman, Juliet A. Williams, Jeffrey A. Engelman, Matthew J. LaMarche, Susan E. Moody, Matthew J. Meyer, Hui Gao, Karrie Wong, William D. Hastings, Silvia Goldoni, Ye Wang, Scott Delach, Colleen Kowal, Guizhi Yang, Xiamei Zhang, Alice Loo, Hongyun Wang, Hengyu Lu, Chen Liu
Purpose:SHP2 inhibitors offer an appealing and novel approach to inhibit receptor tyrosine kinase (RTK) signaling, which is the oncogenic driver in many tumors or is frequently feedback activated in response to targeted therapies including RTK inhibi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23801ceeb7ba68ce8b8d9fedfdac102e
https://doi.org/10.1158/1078-0432.c.6529860
https://doi.org/10.1158/1078-0432.c.6529860