Zobrazeno 1 - 1
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pro vyhledávání: '"Silvia Giambuzzi"'
Autor:
Ornella Letari, Benedetta Buzzi, Paolo Garofalo, Luigi Piero Stasi, Luca Canciani, Gianfranco Caselli, Fabrizio Colace, Roberto Artusi, Matteo Salvi, Clara Bovino, Patrice Larger, Stefano Mandelli, Lorenzo Perugini, Silvia Giambuzzi, Sabrina Pucci, PierLuigi Toro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:2653-2658
Starting from a orexin 1 receptor selective antagonist 4,4-disubstituted piperidine series a novel potent 5-azaspiro[2.4]heptane dual orexin 1 and orexin 2 receptor antagonist class has been discovered. SAR and Pharmacokinetic optimization of this se