Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Silvia Garcia Del Villar"'
Autor:
Teresa Minguez, Cecilia Gotti, Isabel Bermudez, Susan Wonnacott, Timothy Gallagher, Hugo Rego Campello, Adrian J. Mulholland, Kara E. Ranaghan, Deborah K. Shoemark, Silvia Garcia Del Villar, A. Sofia F. Oliveira, Aurélien Honraedt, Richard B. Sessions
Publikováno v:
Rego Campello, H, Del Villar, S G, Honraedt, A, Minguez, T, Oliveira, A S F, Ranaghan, K E, Shoemark, D K, Bermudez, I, Gotti, C, Sessions, R B, Mulholland, A J, Wonnacott, S & Gallagher, T 2018, ' Unlocking Nicotinic Selectivity via Direct C‒H Functionalization of ()-Cytisine ' Chem, vol 4, no. 7, pp. 1710-1725 . DOI: 10.1016/j.chempr.2018.05.007
Rego Campello, H, Garcia Del Villar, S, Honraedt, A, Minguez Viñas, T, Oliveira, S, Ranaghan, K, Shoemark, D, Bermudez, I, Gotti, C, Sessions, R, Mulholland, A, Wonnacott, S & Gallagher, T 2018, ' Unlocking Nicotinic Selectivity via Direct C‒H Functionalization of ()-Cytisine ', Chem, vol. 4, no. 7, pp. 1710-1725 . https://doi.org/10.1016/j.chempr.2018.05.007
Rego Campello, H, Garcia Del Villar, S, Honraedt, A, Minguez Viñas, T, Oliveira, S, Ranaghan, K, Shoemark, D, Bermudez, I, Gotti, C, Sessions, R, Mulholland, A, Wonnacott, S & Gallagher, T 2018, ' Unlocking Nicotinic Selectivity via Direct C‒H Functionalization of ()-Cytisine ', Chem, vol. 4, no. 7, pp. 1710-1725 . https://doi.org/10.1016/j.chempr.2018.05.007
Differentiating nicotinic acetylcholine receptors (nAChR) to target the high-affinity nicotine α4β2 subtype is a major challenge in developing effective addiction therapies. Although cytisine 1 and varenicline 2 (current smoking-cessation agents) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f89c32088138e802c2297d8a42a0d28
https://doi.org/10.1016/j.chempr.2018.05.007
https://doi.org/10.1016/j.chempr.2018.05.007
Publikováno v:
British Journal of Pharmacology. 175:1822-1837
Background and purpose The fifth subunit in the (α4β2)2 α4 nicotinic ACh receptor (nAChR) plays a determining role in the pharmacology of this nAChR type. Here, we have examined the role of the fifth subunit in the ACh responses of the (α4β2)2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9537f4cd18dfc9d3f6f09e5ce4f0c660
https://doi.org/10.1111/bph.13905
https://doi.org/10.1111/bph.13905
Publikováno v:
Biophysical Journal. 110(3)
The α4β2 nicotinic acetylcholine receptor (nAChR) is the most abundant nAChR in the brain. Here it modulates the release of a wide range of neurotransmitters, affecting a wide range of brain functions such as cognition, mood and reward.The nAChR be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f5ad352da91e523173899e4f9e962df
Publikováno v:
International Journal of Molecular Sciences
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2235 (2018)
Volume 19
Issue 8
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2235 (2018)
The insect GABA receptor, RDL (resistance to dieldrin), is a cys-loop ligand-gated ion channel (cysLGIC) that plays a central role in neuronal signaling, and is the target of several classes of insecticides. Many insects studied to date possess one R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7351cca34a4a067bf68cbde0140547b
https://doi.org/10.3390/ijms19082235
https://doi.org/10.3390/ijms19082235