Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Silvia Galván-Peña"'
Autor:
Silvia Galván-Peña, Richard G. Carroll, Carla Newman, Elizabeth C. Hinchy, Eva Palsson-McDermott, Elektra K. Robinson, Sergio Covarrubias, Alan Nadin, Andrew M. James, Moritz Haneklaus, Susan Carpenter, Vincent P. Kelly, Michael P. Murphy, Louise K. Modis, Luke A. O’Neill
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Host metabolic reprogramming plays a role in functional responses against pathogens. Here, the authors characterise malonylated proteins in macrophages and show that malonylation of the glycolytic enzyme GAPDH impacts cytokine production by modulatin
Externí odkaz:
https://doaj.org/article/4a15ae022f184e95bae97dad5d2e7a5a
SUMMARYDysbiosis in the gut microbiota impacts several systemic diseases. One possible mechanism is the migration of perturbed intestinal immunocytes to extra-intestinal tissues. Combining the Kaede photoconvertible mouse model and single-cell genomi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a656c4f8bcb71222738610a5dc732252
https://doi.org/10.1101/2022.11.16.516757
https://doi.org/10.1101/2022.11.16.516757
Autor:
Bola S. Hanna, Gang Wang, Silvia Galván-Peña, Alexander O. Mann, Ricardo N. Ramirez, Andrés R. Muñoz-Rojas, Kathleen Smith, Min Wan, Christophe Benoist, Diane Mathis
Publikováno v:
Immunity. 56:829-846.e8
Autor:
Christophe Benoist, Kaitavjeet Chowdhary, Elke Mühlberger, Liang Yang, Hyung Suk Oh, Yangyang Zhu, Juliette Leon, Lael M. Yonker, Adam J. Hume, Silvia Galván-Peña, David M. Knipe, Daniel A Michelson, Brinda Vijaykumar, Felicia Chen, Judith Olejnik
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance By modeling in vitro the cross-talk between epithelial and immune cells, this work provides possible origins for the profound inflammatory perturbations that are a hallmark of COVID-19, and the relative protection of children from severe
Autor:
Xu G. Yu, Diane Mathis, Silvia Galván-Peña, Daniel P Worrall, Daniel A Michelson, Juliette Leon, Alicja Piechocka-Trocha, Bruce D. Walker, Christophe Benoist, Kaitavjeet Chowdhary, Jonathan Z. Li, Musie Ghebremichael, Felicia Chen, Liang Yang, Kathryn E Hall, Zachary Manickas-Hill, Brinda Vijaykumar, Angela Magnuson
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
bioRxiv
bioRxiv
Significance Regulatory T cells (Tregs) are responsible for restraining excessive inflammation, a hallmark of COVID-19. We identified a striking phenotype in Tregs from patients with severe disease, as well as an interesting role for interleukin (IL)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99ddf4f9d210a708c6c959f65a15d242
https://doi.org/10.1101/2020.12.11.416180
https://doi.org/10.1101/2020.12.11.416180
Autor:
Zhen Yang, Deepshika Ramanan, Christophe Benoist, Liang Yang, Aleksandar Kostic, Diane Mathis, Esen Sefik, Silvia Galván-Peña, Dennis L. Kasper, Tatyana V. Golovkina, Meng Wu
Publikováno v:
Cell. 181(6)
At the species level, immunity depends on the selection and transmission of protective components of the immune system. A microbe-induced population of RORγ-expressing regulatory T cells (Tregs) is essential in controlling gut inflammation. We uncov
Autor:
Richard G. Carroll, Martha Triantafilou, Evanna L. Mills, Amaya I. Wolf, Kathy Triantafilou, Clare E. Bryant, Silvia Galván-Peña, Robin Olden, Seth L. Masters, Meghana N. Patel
Publikováno v:
Trends in Molecular Medicine. 23:165-180
The inflammasome is a cytoplasmic protein complex that processes interleukins (IL)-1β and IL-18, and drives a form of cell death known as pyroptosis. Oligomerization of this complex is actually the second step of activation, and a priming step must
Autor:
Richard G. Carroll, Elizabeth C. Hinchy, Vincent P. Kelly, Eva M. Palsson-McDermott, Moritz Haneklaus, Elektra K. Robinson, Andrew M. James, Louise K. Modis, Silvia Galván-Peña, Michael P. Murphy, Alan Nadin, Sergio Covarrubias, Susan Carpenter, Carla F. Newman, Luke A. J. O'Neill
Publikováno v:
Nature communications, vol 10, iss 1
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Macrophages undergo metabolic changes during activation that are coupled to functional responses. The gram negative bacterial product lipopolysaccharide (LPS) is especially potent at driving metabolic reprogramming, enhancing glycolysis and altering
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b634af5584f47f1d546a4bcfc38aa5c8
https://escholarship.org/uc/item/4wq0v1m2
https://escholarship.org/uc/item/4wq0v1m2
Autor:
Martha Triantafilou, Luke A. J. O'Neill, Kathy Triantafilou, Louise K. Modis, Zbigniew Zaslona, Stefano Angiari, Daniel C. Sévin, Silvia Galván-Peña, Emma Koppe, Richard G. Carroll
Publikováno v:
The Journal of Biological Chemistry
Different immune activation states require distinct metabolic features and activities in immune cells. For instance, inhibition of fatty acid synthase (FASN), which catalyzes the synthesis of long-chain fatty acids, prevents the proinflammatory respo
Autor:
Luke A. J. O'Neill, Silvia Galván-Peña
Publikováno v:
The FASEB Journal. 29