Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Silvia Espejel"'
Autor:
Andrew Y. Lee, Holger Willenbring, Silvia Espejel, Garrett R. Roll, Keisuke Okita, Diana J. Laird, Jenny Y. Zhang, Shinya Yamanaka, K. John McLaughlin
Publikováno v:
Journal of Clinical Investigation. 120:3120-3126
The ability to generate induced pluripotent stem (iPS) cells from a patient's somatic cells has provided a foundation for organ regeneration without the need for immune suppression. However, it has not been established that the differentiated progeny
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8af5ccb357b55dd53c39fcb5249bf022
https://doi.org/10.1172/jci43267
https://doi.org/10.1172/jci43267
Publikováno v:
Annals of Neurology. 66:100-109
Recent reports have demonstrated that bone marrow-derived cells (BMDCs) can fuse with cells in brain, liver, muscle, heart, intestine and kidney.1–9 The factors that trigger in vivo cell fusion and the functional consequences of these events remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824348142d7c4f092575c77f774b6f3c
https://doi.org/10.1002/ana.21670
https://doi.org/10.1002/ana.21670
Autor:
Silvia Espejel, Maria A. Blasco
Publikováno v:
Experimental Cell Research. 276:242-248
In contrast to human primary cells, mouse embryonic fibroblasts (MEF) do not show telomere shortening-mediated replicative senescence due to the fact that they have telomerase activity and show sufficiently long telomeres. Instead, it is now generall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d31faaf252dfae321c834ad56f56bd4
https://doi.org/10.1006/excr.2002.5533
https://doi.org/10.1006/excr.2002.5533
Autor:
K. John McLaughlin, Jack Harbell, Sigrid Eckardt, Holger Willenbring, Garrett R. Roll, Silvia Espejel
Publikováno v:
Stem cells (Dayton, Ohio), vol 32, iss 7
Parthenogenesis is the development of an oocyte without fertilization. Mammalian parthenogenetic (PG) embryos are not viable, but can develop into blastocysts from which embryonic stem cells (ESCs) have been derived in mouse and human. PG ESCs are fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc7f3b6abfed71e6f67fa6534a88592b
https://escholarship.org/uc/item/3jc4c8qx
https://escholarship.org/uc/item/3jc4c8qx
Autor:
Minh Thu Luu, Frederic F. Clermont, Kelly A. Harradine, Henri Plauchu, Musa Zaid, Christopher C.W. Hughes, Ritu Roy, Mamie Nakayama Higgins, C.J.J. Westermann, David A. Quigley, Gaetan Lesca, Johannes Kristian Ploos Van Amstel, Michael Benzinou, Bradley E. Aouizerat, Juan Arbelaez, Sophie Giraud, Rosemary J. Akhurst, Tom G. W. Letteboer, Sophie Dupuis-Girod, Silvia Espejel, Jai-Hyun Kim
Publikováno v:
Nature Communications. 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deb5b7541f04250c8a676314539bbbe8
https://doi.org/10.1038/ncomms2164
https://doi.org/10.1038/ncomms2164
Autor:
Silvia Espejel, Michael Benzinou, Sophie Dupuis-Girod, Tom G. W. Letteboer, Bradley E. Aouizerat, Musa Zaid, David A. Quigley, Sophie Giraud, C.J.J. Westermann, Rosemary J. Akhurst, Johannes Kristian Ploos Van Amstel, Jai-Hyun Kim, Juan Arbelaez, Frederic F. Clermont, Gaetan Lesca, Henri Plauchu, Christopher C.W. Hughes, Mamie Nakayama Higgins, Minh Thu Luu, Ritu Roy, Kelly A. Harradine
Publikováno v:
Nature Communications. 3
Hereditary haemorrhagic telangiectasia (HHT) [corrected] is a vascular dysplasia syndrome caused by mutations in transforming growth factor-β/bone morphogenetic protein pathway genes, ENG and ACVRL1. HHT [corrected] shows considerable variation in c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e28eff322369641107410c74860a272c
https://doi.org/10.1038/ncomms1633
https://doi.org/10.1038/ncomms1633
Autor:
Peter Klatt, Silvia Espejel, Juan Martín-Caballero, Gilbert de Murcia, Juana M. Flores, Josiane Ménissier-de Murcia, Maria A. Blasco, Guillermo E. Taccioli
Publikováno v:
The Journal of Cell Biology
The DNA repair proteins poly(ADP-ribose) polymerase-1 (PARP-1), Ku86, and catalytic subunit of DNA-PK (DNA-PKcs) have been involved in telomere metabolism. To genetically dissect the impact of these activities on telomere function, as well as organis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84494784316f6758ddc9a7b078814410
https://pubmed.ncbi.nlm.nih.gov/15545322
https://pubmed.ncbi.nlm.nih.gov/15545322
Autor:
Peter Klatt, Silvia Espejel, Marta Martín, Juana M. Flores, Juan Martín-Caballero, Maria A. Blasco
Non-homologous end joining (NHEJ) is the principal repair mechanism used by mammalian cells to cope with double-strand breaks (DSBs) that continually occur in the genome. One of the key components of the mammalian NHEJ machinery is the DNA-PK complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c690416009ecd1fb55c1fd3df579b510
https://europepmc.org/articles/PMC1299048/
https://europepmc.org/articles/PMC1299048/
Autor:
Maria A. Blasco, Darren Gae, Susan M. Bailey, Sonia Franco, Guillermo E. Taccioli, Silvia Espejel, Antonella Sgura
DNA-PKcs is the catalytic subunit of the DNA-dependent protein kinase (DNA-PK) complex that functions in the non-homologous end-joining of double-strand breaks, and it has been shown previously to have a role in telomere capping. In particular, DNA-P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63a629153944474d5b15437f7831a77
https://europepmc.org/articles/PMC137185/
https://europepmc.org/articles/PMC137185/
Autor:
Juan C. Cigudosa, Sonia Franco, Silvia Espejel, Sandra Rodriguez-Perales, Simon Bouffler, Maria A. Blasco
Publikováno v:
The EMBO journal. 21(9)
Here we analyze the functional interaction between Ku86 and telomerase at the mammalian telomere by studying mice deficient for both proteins. We show that absence of Ku86 prevents the end-to-end chromosomal fusions that result from critical telomere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0b40c807f1aa1d70c56121344d39a0d
https://pubmed.ncbi.nlm.nih.gov/11980718
https://pubmed.ncbi.nlm.nih.gov/11980718