3-aryl-indolinones derivatives as antiplasmodial agents: synthesis, biological activity and computational analysis

Autor: Marco Mellado, Guilherme Eduardo de Souza, Rafael Victorio Carvalho Guido, Luis F. Aguilar, Ayelen Luczywo, Lucía G González, Silvia E. Asis, Juan José Casal, Glaucius Oliva, Anna Caroline Campos Aguiar, Juliana Oliveira de Souza

Publikováno v: Natural Product Research. 36:3887-3893

Malaria is an infectious illness, affecting vulnerable populations in Third World countries. Inspired by natural products, indole alkaloids have been used as a nucleus to design new antimalarial drugs. So, eighteen oxindole derivatives, aza analogues

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35323b55724ac132ab697057f20e9f1e
https://doi.org/10.1080/14786419.2021.1895149

Synthesis, anti-tuberculosis activity and QSAR study of 2,4-diarylquinolines and analogous polycyclic derivatives

Autor: Ayelen Luczywo, Graciela Buldain, Juan P. Carnevale, Gisela Celeste Muscia, Ailen Rodríguez Ó Toole, María Victoria Peláez, Silvia E. Asis, Juan José Casal

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Arabian Journal of Chemistry, Vol 12, Iss 7, Pp 932-945 (2019)

The multicomponent syntheses of 2,4-di-aryl-quinolines and analogous polycyclic derivatives as anti-tuberculosis agents were described. They were prepared via Beyer and Friedländer methods under microwave irradiation in short reaction times and good

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec077729c2f12c0cc2d4a38319c8f0d
https://www.sciencedirect.com/science/article/pii/S1878535218302053

2D/3D-QSAR Model Development Based on a Quinoline Pharmacophoric Core for the Inhibition of Plasmodium falciparum: An In Silico Approach with Experimental Validation

Autor: Marcos Lorca, Gisela C. Muscia, Susana Pérez-Benavente, José M. Bautista, Alison Acosta, Cesar González, Gianfranco Sabadini, Jaime Mella, Silvia E. Asís, Marco Mellado

Publikováno v: Pharmaceuticals, Vol 17, Iss 7, p 889 (2024)

Malaria is an infectious disease caused by Plasmodium spp. parasites, with widespread drug resistance to most antimalarial drugs. We report the development of two 3D-QSAR models based on comparative molecular field analysis (CoMFA), comparative molec

Externí odkaz: https://doaj.org/article/3ca12b69adc44b4aad3a7e01a8279369

Antimalarial activity of novel imidazoisoquinolinone derivatives correlates with heme binding affinity

Autor: Silvia E. Asis, Ana M. Bruno, Juan José Casal, Emilse Soledad Leal, Mariela Bollini

Publikováno v: Medicinal Chemistry Research. 24:1496-1503

A series of novel imidazoisoquinolinone derivatives were synthesized and evaluated for in vitro antimalarial efficacy against chloroquine sensitive GHA strain of Plasmodium falciparum. Compounds 2, 4, 6, 9, and 17 revealed moderate to good activities

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ede49397846fd9690f2c812210e9f14
https://doi.org/10.1007/s00044-014-1231-6

ChemInform Abstract: Ultrasound Assisted Pictet-Spengler Synthesis of Tetrahydro-β-carboline Derivatives

Autor: Gisela Celeste Muscia, Graciela Buldain, Leonardo Oscar de María, Silvia E. Asis

Publikováno v: ChemInform. 47

The synthesis of twelve tetrahydro-β-carboline derivatives 3a, 3b, 3c, 3d, 3e, 3f, 3g, 3h, 3i, 3j, 3k, 3l prepared via the Pictet–Spengler reaction is described. The reaction of tryptamine and a variety of arylaldehydes were carried out under ultr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5dbf6615cbca3b1cfb4c769a73e3fc95
https://doi.org/10.1002/chin.201632126