Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Silvia Dambacher"'
Results of a Prospective Non-Interventional Post-Authorization Safety Study of Idelalisib in Germany
Autor:
Manuela A. Hoechstetter, Wolfgang Knauf, Silvia Dambacher, Nike Hucke, Kristin Höhne, Anna van Troostenburg, Heribert Ramroth, Wolfgang Abenhardt, Mathias Rummel
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 22:e777-e787
In pivotal studies, idelalisib demonstrated remarkable efficacy and manageable tolerability in patients with chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL). This prospective, multicenter, non-interventional post-authorization study a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0cd5f79e5c9c275fbc5b46b168f262f
https://doi.org/10.1016/j.clml.2022.04.007
https://doi.org/10.1016/j.clml.2022.04.007
Autor:
Gunnar Schotta, Ingrid Grummt, Marcel Andre Dammert, David Brocks, Holger Bierhoff, Silvia Dambacher
Publikováno v:
Molecular Cell. 54:675-682
A complex network of regulatory pathways links transcription to cell growth and proliferation. Here we show that cellular quiescence alters chromatin structure by promoting trimethylation of histone H4 at lysine 20 (H4K20me3). In contrast to pericent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a4d82e3ef097323dc215dbc0391b016
https://doi.org/10.1016/j.molcel.2014.03.032
https://doi.org/10.1016/j.molcel.2014.03.032
Autor:
Maike Schulte, Harald von Melchner, Gunnar Schotta, Zuzana Storchova, Andreas Maiser, Lothar Schermelleh, Stanimir Dulev, Stefan Wörz, Jan-Philipp Mallm, Matthias Hahn, Karsten Rippe, Dennis Sadic, Simon Eck, Pierre Debs, Heinrich Leonhardt, Karl Rohr, Silvia Dambacher, Anastasia Yurievna Kuznetsova
Publikováno v:
Genes & Development. 27:859-872
Cohesin plays an important role in chromatid cohesion and has additional functions in higher-order chromatin organization and in transcriptional regulation. The binding of cohesin to euchromatic regions is largely mediated by CTCF or the mediator com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d8b9dcef98a290995b736250e85e445
https://doi.org/10.1101/gad.210377.112
https://doi.org/10.1101/gad.210377.112
Autor:
Christian Hoischen, Wen Deng, Gunnar Schotta, Heinrich Leonhardt, Matthias Hahn, Alexander Nuber, Dennis Sadic, Jonathan Fröhlich, Stephan Diekmann, Silvia Dambacher
Publikováno v:
Nucleus
Centromeres are important structural constituents of chromosomes that ensure proper chromosome segregation during mitosis by providing defined sites for kinetochore attachment. In higher eukaryotes, centromeres have no specific DNA sequence and thus,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ae5fc89f47461dc664e822a3211ff16
https://doi.org/10.4161/nucl.18955
https://doi.org/10.4161/nucl.18955
Publikováno v:
Journal of Applied Physiology. 109:232-242
Heterochromatin is a repressive chromatin state that is characterized by densely packed DNA and low transcriptional activity. Heterochromatin-induced gene silencing is important for mediating developmental transitions, and in addition, it has more gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc3583e0cac2bd5deb80f565db8065d
https://doi.org/10.1152/japplphysiol.00053.2010
https://doi.org/10.1152/japplphysiol.00053.2010
Publikováno v:
Epigenomics. 5(6)
Epigenetic mechanisms are crucial to stabilize cell type-specific gene-expression programs. However, during differentiation, these programs need to be modified – a complex process that requires dynamic but tightly controlled rearrangements in the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe28b637c989201e25ed7acfa3a0b7e7
https://pubmed.ncbi.nlm.nih.gov/24283883
https://pubmed.ncbi.nlm.nih.gov/24283883
Publikováno v:
Heredity. 105(1)
Epigenetic mechanisms contribute to the establishment and maintenance of cell-type-specific gene expression patterns. In this review, we focus on the functions of histone lysine methylation in the context of epigenetic gene regulation during developm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e4de5dea53937ea5bf7bb4890d6050
https://pubmed.ncbi.nlm.nih.gov/20442736
https://pubmed.ncbi.nlm.nih.gov/20442736
Publikováno v:
Cell Cycle
Cohesin plays an important role in chromatid cohesion and has additional functions in higher-order chromatin organization and in transcriptional regulation. The binding of cohesin to euchromatic regions is largely mediated by CTCF or the mediator com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfce0298c409522e53c4af8fbfd4b24
http://europepmc.org/articles/PMC3875662
http://europepmc.org/articles/PMC3875662
Publikováno v:
Nucleic Acids Research
The von Hippel-Lindau tumor suppressor protein (pVHL) is inactivated in the hereditary cancer syndrome von Hippel-Lindau disease and in the majority of sporadic renal carcinomas. pVHL is the substrate-binding subunit of the CBC(VHL) ubiquitin ligase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba98328b647f29f1ea3cdc560452642
https://doi.org/10.1093/nar/gkm932
https://doi.org/10.1093/nar/gkm932