Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Silvia Cristofanon"'
Autor:
Elena Signaroldi, Pasquale Laise, Silvia Cristofanon, Arianna Brancaccio, Elisa Reisoli, Sina Atashpaz, Maria Rosa Terreni, Claudio Doglioni, Giancarlo Pruneri, Paolo Malatesta, Giuseppe Testa
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate transcriptomic and epigenomic analyses to define Polycomb-dependent networks that promote gliomagenesis, and find that the Polycomb-dependent silencing of th
Externí odkaz:
https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec
Autor:
Dominic Stadel, Silvia Cristofanon, Behnaz Ahangarian Abhari, Kurt Deshayes, Kerry Zobel, Domagoj Vucic, Klaus-Michael Debatin, Simone Fulda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 12, Pp 1162-1170 (2011)
Defects in apoptosis contribute to treatment resistance and poor outcome of pancreatic cancer, calling for novel therapeutic strategies. Here, we provide the first evidence that nuclear factor (NF) κB is required for Smac mimetic– mediated sensiti
Externí odkaz:
https://doaj.org/article/157c6c0189dc49fbaf8ab13aa10bfc52
Autor:
Bram Laukens, Claudia Jennewein, Barbara Schenk, Nele Vanlangenakker, Alexander Schier, Silvia Cristofanon, Kerry Zobel, Kurt Deshayes, Domagoj Vucic, Irmela Jeremias, Mathieu J.M. Bertrand, Peter Vandenabeele, Simone Fulda
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 10, Pp 971-979 (2011)
Searching for new strategies to bypass apoptosis resistance, we investigated the potential of the Smac mimetic BV6 in Jurkat leukemia cells deficient in key molecules of the death receptor pathway. Here, we demonstrate for the first time that Smac mi
Externí odkaz:
https://doaj.org/article/2b0c5604cd474578b8041b5d5110976c
Autor:
Simone Fulda, Albert C. Ludolph, Klaus-Michael Debatin, Franz Rödel, Stephanie Hehlgans, Sri HariKrishna Vellanki, Liane Wagner, Silvia Cristofanon, Sabine Karl, Viola Marschall, Claudia Jennewein, Rebecca Berger
PDF file-54KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5944f77f33dad565e1758c59fb6563d0
https://doi.org/10.1158/1535-7163.22497226
https://doi.org/10.1158/1535-7163.22497226
Autor:
Simone Fulda, Albert C. Ludolph, Klaus-Michael Debatin, Franz Rödel, Stephanie Hehlgans, Sri HariKrishna Vellanki, Liane Wagner, Silvia Cristofanon, Sabine Karl, Viola Marschall, Claudia Jennewein, Rebecca Berger
PDF file-82KB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049e96508f920250e7fd2cf555adcd50
https://doi.org/10.1158/1535-7163.22497232.v1
https://doi.org/10.1158/1535-7163.22497232.v1
Autor:
Arianna Brancaccio, Elisa Reisoli, Giuseppe Testa, Paolo Malatesta, Maria Rosa Terreni, Sina Atashpaz, E. Signaroldi, Silvia Cristofanon, Pasquale Laise, Claudio Doglioni, Giancarlo Pruneri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Nature Communications
Nature Communications
Malignant gliomas constitute one of the most significant areas of unmet medical need, owing to the invariable failure of surgical eradication and their marked molecular heterogeneity. Accumulating evidence has revealed a critical contribution by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614af46702ceb5a11e4e5f3295ded701
https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec
https://doaj.org/article/082aa49bf9c74fc6ad7c119e84550fec
Autor:
Kenny Black, Jioji N. Tabudravu, Klaus D. Feussner, David H. Green, Florence Folmer, Godofredo Solano, Silvia Cristofanon, Marcel Jaspars, Frithjof C. Küpper, Marc Diederich, Estelle Henry, William G.L. Aalbersberg, Maria Dicato
Publikováno v:
Biochemical Pharmacology. 78:592-606
The deregulated activation of NF-kappaB is associated with cancer development and inflammatory diseases. With an aim to find new NF-kappaB inhibitors, we purified and characterized compounds from extracts of the Fijian sponge Rhabdastrella globostell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9fd7438ac6615c8ef8ce8209909f1eb
https://doi.org/10.1016/j.bcp.2009.05.009
https://doi.org/10.1016/j.bcp.2009.05.009
Autor:
Marc Diederich, Claudia Cerella, Silvia Cristofanon, Mario Dicato, Flavia Radogna, Milena De Nicola, Maria D'alessio, Lina Ghibelli
Publikováno v:
Annals of the New York Academy of Sciences. 1171:583-590
We have previously shown that oxidative stress induced by an apoptogenic dose of H(2)O(2) leads to a temporary block of glycolytic flux via inactivation of the glycolytic key enzyme glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in U937 cells. This
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::373ec6e1882c4d625003f307e16d2dd3
https://doi.org/10.1111/j.1749-6632.2009.04723.x
https://doi.org/10.1111/j.1749-6632.2009.04723.x
Autor:
Marie Hélène Teiten, Marc Diederich, Michael Schnekenburger, Sandrine Daubeuf, Bharat B. Aggarwal, Silvia Cristofanon, Isabelle Buck, Mario Dicato, Simone Reuter, Serge Eifes, Athanase Visvikis
Publikováno v:
Biochemical Pharmacology
Biochemical Pharmacology, Elsevier, 2009, 77 (3), pp.397-411. ⟨10.1016/j.bcp.2008.09.041⟩
Biochemical Pharmacology, Elsevier, 2009, 77 (3), pp.397-411. ⟨10.1016/j.bcp.2008.09.041⟩
International audience; Gamma-glutamyltransferase (GGT) cleaves the gamma-glutamyl moiety of glutathione (GSH), an endogenous antioxidant, and is involved in mercapturic acid metabolism and in cancer drug resistance when overexpressed. Moreover, GGT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fa7a1d3345fb0eef4894828b8e58f4
https://doi.org/10.1016/j.bcp.2008.09.041
https://doi.org/10.1016/j.bcp.2008.09.041
Autor:
Silvia Cristofanon, Isabelle Buck, Simone Reuter, Franck Morceau, Sébastien Chateauvieux, Caroline Heintz, Mario Dicato, Marc Diederich
Publikováno v:
Biochemical Pharmacology. 76:1229-1239
The proinflammatory cytokine tumor necrosis factor alpha (TNFalpha) has been linked to inflammation- and cancer-related anemia, which reduces both quality of life and prognosis of patients. The aim of this study was to reveal molecular mechanisms lin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eb142885068ddfbacbd6e603411c95f
https://doi.org/10.1016/j.bcp.2008.08.025
https://doi.org/10.1016/j.bcp.2008.08.025