Výsledky vyhledávání - "Silvia C. Hernandez"

Akademický článek

Protective effects of macrophage-specific integrin α5 in myocardial infarction are associated with accentuated angiogenesis

Autor: Ruoshui Li, Bijun Chen, Akihiko Kubota, Anis Hanna, Claudio Humeres, Silvia C. Hernandez, Yang Liu, Richard Ma, Izabela Tuleta, Shuaibo Huang, Harikrishnan Venugopal, Fenglan Zhu, Kai Su, Jun Li, Jinghang Zhang, Deyou Zheng, Nikolaos G. Frangogiannis

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)

Abstract Macrophages sense changes in the extracellular matrix environment through the integrins and play a central role in regulation of the reparative response after myocardial infarction. Here we show that macrophage integrin α5 protects the infa

Externí odkaz: https://doaj.org/article/2c80b06b17ca43dea72a0bd195b86518

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Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium

Autor: Bijun Chen, Ruoshui Li, Silvia C. Hernandez, Anis Hanna, Kai Su, Arti V. Shinde, Nikolaos G. Frangogiannis

Publikováno v: Journal of Molecular and Cellular Cardiology. 171:1-15

TGF-βs regulate macrophage responses, by activating Smad2/3. We have previously demonstrated that macrophage-specific Smad3 stimulates phagocytosis and mediates anti-inflammatory macrophage transition in the infarcted heart. However, the role of mac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe832937b0cc93ba64a767365117ca71
https://doi.org/10.1016/j.yjmcc.2022.06.009

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CTCF chromatin residence time controls three-dimensional genome organization, gene expression and DNA methylation in pluripotent cells

Publikováno v: Dev Cell
Nature Cell Biology, 23(8), 881-893. Nature Publishing Group

The 11 zinc finger (ZF) protein CTCF regulates topologically associating domain formation and transcription through selective binding to thousands of genomic sites. Here, we replaced endogenous CTCF in mouse embryonic stem cells with green-fluorescen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dfc5062424a1bb8d40df0bdfc26739
https://doi.org/10.1038/s41556-021-00722-w

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The role of endogenous Smad7 in regulating macrophage phenotype following myocardial infarction

Autor: Jun Li, Ruoshui Li, Izabela Tuleta, Silvia C. Hernandez, Claudio Humeres, Anis Hanna, Bijun Chen, Nikolaos G. Frangogiannis

Publikováno v: FASEB J

Smad7 restrains TGF-β responses, and has been suggested to exert both pro- and anti-inflammatory actions that may involve effects on macrophages. Myocardial infarction triggers a macrophage-driven inflammatory response that not only plays a central

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee06bc3ea6f503bc5b1e20426b092c1b
https://europepmc.org/articles/PMC9216182/

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Continuous Identity Cognitive Therapy: Feasibility and Acceptability of a Novel Intervention for Suicidal Symptoms

Autor: Josephine Ridley, Lisa B. Dixon, Yosef Sokol, Marianne Goodman, Silvia C Hernandez, Yulia Landa

Publikováno v: Journal of Cognitive Psychotherapy. 35:64-80

We introduce continuous identity cognitive therapy (CI-CT), a novel suicide intervention. CI-CT was developed based on evidence that suicidal individuals have difficulty viewing and experiencing continuity with their perceived future self, and having

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a67f2885969deeb48602387f71a3c8e3
https://doi.org/10.1891/jcpsy-d-20-00023

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Single-Cell RNA Sequencing Analysis Reveals a Crucial Role for CTHRC1 (Collagen Triple Helix Repeat Containing 1) Cardiac Fibroblasts After Myocardial Infarction

Publikováno v: Circulation

Background: Cardiac fibroblasts (CFs) have a central role in the ventricular remodeling process associated with different types of fibrosis. Recent studies have shown that fibroblasts do not respond homogeneously to heart injury. Because of the limit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77d302f8dd59aca9c67e94d970efc18e
https://doi.org/10.1161/circulationaha.119.044557

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Delivery of cardiovascular progenitors with biomimetic microcarriers reduces adverse ventricular remodeling in a rat model of chronic myocardial infarction

Autor: Carmen Roncal, María J. Blanco-Prieto, Laura Saludas, Beatriz Pelacho, Adrián Ruiz-Villalba, Elisa Garbayo, Silvia C. Hernandez, B. Sanchez, Igor F. Palacios, Gloria Abizanda, Felipe Prosper

Publikováno v: Dadun. Depósito Académico Digital de la Universidad de Navarra
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Despite tremendous progress in cell-based therapies for heart repair, many challenges still exist. To enhance the therapeutic potential of cell therapy one approach is the combination of cells with biomaterial delivery vehicles. Here, we developed a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043efba8310072a746042f7ba4b3330c
https://hdl.handle.net/10171/63703

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Suicide among older adults: Interactions among key risk factors

Autor: James C. Overholser, Craig A. Stockmeier, Silvia C Hernandez, Kristie L Philips, James Lavacot

Publikováno v: International journal of psychiatry in medicine. 56(6)

Objective The present study aimed to understand how key risk factors of older adult suicide interact to ultimately lead to death by suicide using data collected post-mortem. Method A psychological autopsy was used to gather detailed information about

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::152728b65ec5713ab679fd6eec5f9fb4
https://pubmed.ncbi.nlm.nih.gov/33322985

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