Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Silvia C Lenzken"'
Autor:
Silvia Vivarelli, Silvia C Lenzken, Marc-David Ruepp, Francesco Ranzini, Andrea Maffioletti, Reinaldo Alvarez, Oliver Mühlemann, Silvia M L Barabino
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61980 (2013)
Paraquat (PQ) is a neurotoxic herbicide that induces superoxide formation. Although it is known that its toxic properties are linked to ROS production, the cellular response to PQ is still poorly understood. We reported previously that treatment with
Externí odkaz:
https://doaj.org/article/ccf963e58a914e9e9bf823e56707334d
Publikováno v:
Biomolecules, Vol 5, Iss 4, Pp 2363-2387 (2015)
Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in t
Externí odkaz:
https://doaj.org/article/86319b8999e54f21a9890b83ab62fd66
Autor:
Cise Kizilirmak, Marc-David Ruepp, Silvia C. Lenzken, Francesca Conte, Marco Antonaci, Oliver Mühlemann, Fabio Biella, Alessia Loffreda, Angela Bachi, Antonella Ronchi, Stefan Reber, Brunno R. Levone, Silvia M.L. Barabino, Giuseppe Filosa
RNA-binding proteins (RBPs) are emerging as important effectors of the cellular DNA damage response (DDR). The RBP FUS is implicated in RNA metabolism and DNA repair, and it undergoes reversible liquid-liquid phase separation (LLPS) in vitro. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8180184497f39eed0c89c98f543a5b54
https://doi.org/10.1101/798884
https://doi.org/10.1101/798884
Autor:
Daniel Jutzi, Angela Bachi, Giuseppe Filosa, Stefan Reber, Martino Colombo, Silvia M.L. Barabino, Marc-David Ruepp, Silvia C. Lenzken, Rémy Bruggmann, Jolanda Stettler, Oliver Mühlemann, Christoph Schweingruber
Publikováno v:
Europe PubMed Central
Reber, S, Stettler, J, Filosa, G, Colombo, M, Jutzi, D, Lenzken, S C, Schweingruber, C, Bruggmann, R, Bachi, A, Barabino, S M, Mühlemann, O & Ruepp, MD 2016, ' Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants ', The EMBO journal, vol. 35, no. 14, pp. 1504-1521 . https://doi.org/10.15252/embj.201593791
Reber, S, Stettler, J, Filosa, G, Colombo, M, Jutzi, D, Lenzken, S C, Schweingruber, C, Bruggmann, R, Bachi, A, Barabino, S M, Mühlemann, O & Ruepp, MD 2016, ' Minor intron splicing is regulated by FUS and affected by ALS-associated FUS mutants ', The EMBO journal, vol. 35, no. 14, pp. 1504-1521 . https://doi.org/10.15252/embj.201593791
Fused in sarcoma (FUS) is a ubiquitously expressed RNA-binding protein proposed to function in various RNA metabolic pathways, including transcription regulation, pre-mRNA splicing, RNA transport and microRNA processing. Mutations in the FUS gene wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::497c9dc6f0de2d607b0d6c6d18700b48
https://doi.org/10.15252/embj.201593791
https://doi.org/10.15252/embj.201593791
Publikováno v:
Biomolecules
Biomolecules, Vol 5, Iss 4, Pp 2363-2387 (2015)
Biomolecules, Vol 5, Iss 4, Pp 2363-2387 (2015)
Posttranscriptional modifications of messenger RNAs (mRNAs) are key processes in the fine-tuning of cellular homeostasis. Two major actors in this scenario are RNA binding proteins (RBPs) and microRNAs (miRNAs) that together play important roles in t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f8073c5639115a9cf1562bd32d127a6
https://doi.org/10.3390/biom5042363
https://doi.org/10.3390/biom5042363
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 5:565-576
In mammalian cells in general and in neurons in particular, mRNA maturation, translation, and degradation are highly complex and dynamic processes. RNA-binding proteins (RBPs) play crucial roles in all these events. First, they participate in the cho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc79778c07fff7fd04cf21ff935260b8
https://doi.org/10.1002/wrna.1231
https://doi.org/10.1002/wrna.1231
Autor:
Marco Bianchi, Silvia M.L. Barabino, Silvia C. Lenzken, Gabriele Fontana, Giuseppe Filosa, Raffaele A. Calogero, Aurora Rigamonti, Reinaldo Alvarez
Publikováno v:
Nucleic Acids Research
Alternative splicing of terminal exons increases transcript and protein diversity. How physiological and pathological stimuli regulate the choice between alternative terminal exons is, however, largely unknown. Here, we show that Brahma (BRM), the AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::182727057c0a4534243108d6575b38c2
https://pubmed.ncbi.nlm.nih.gov/27591253
https://pubmed.ncbi.nlm.nih.gov/27591253
Autor:
Stefano Govoni, Cristina Lanni, Silvia C. Lenzken, Serena Stanga, Marco Racchi, Fabio De Leonardis
Publikováno v:
Journal of Alzheimer's disease : JAD, Vol. 20, no. 4, p. 1133-41 (2010)
The amyloid-beta protein precursor (AbetaPP) is an integral membrane protein subjected to constitutive and regulated proteolytic processing. We have previously demonstrated that protein kinase C epsilon (PKCepsilon) plays a key role in the regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dabda0d8febacd96b75723b02186e6f
https://doi.org/10.3233/jad-2010-090232
https://doi.org/10.3233/jad-2010-090232
Autor:
Emanuela Corsini, Federica Pisano, Annalisa Zuccotti, Françoise Rousset, Fabio Canneva, Marco Racchi, Stefano Govoni, Igor Del Vecchio, Silvia C. Lenzken
Publikováno v:
Gene. 430:17-29
RACK1 (Receptor for Activated C Kinase 1) is a scaffold protein for different kinases and membrane receptors. Previously, we characterized an age-dependent decline of RACK1 protein expression which could be counteracted with DHEA (dehydroepiandroster
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c022865380a41d6fe0da7a6eafe2537
https://doi.org/10.1016/j.gene.2008.10.005
https://doi.org/10.1016/j.gene.2008.10.005
Autor:
Igor Del Vecchio, Silvia C. Lenzken, Alessia Pascale, Francesca Pistoia, Marco Racchi, Cristina Lanni, Stefano Govoni
Publikováno v:
Pharmacological Research. 57:196-213
Memory, attention and creativity represent three different cognitive domains, which are interconnected and contribute the "mental performance" of an individual. Modern neuroscience has investigated some of the neuronal circuits and of the neurotransm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebccea21d4a87f157aa1a4096cc941d
https://doi.org/10.1016/j.phrs.2008.02.004
https://doi.org/10.1016/j.phrs.2008.02.004