Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Silvia C Finnemann"'
Autor:
Yemsratch T Akalu, Maria E Mercau, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Publikováno v:
eLife, Vol 11 (2022)
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role
Externí odkaz:
https://doaj.org/article/43fad56f4e26479584968f8d6e15f037
Autor:
Delu Song, Brooks Wilson, Liangliang Zhao, Rupak Bhuyan, Mausumi Bandyopadhyay, Arkady Lyubarsky, Chen Yu, Yafeng Li, Levi Kanu, Takashi Miwa, Wen-Chao Song, Silvia C Finnemann, Bärbel Rohrer, Joshua L Dunaief
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0166348 (2016)
Complement dysregulation plays a key role in the pathogenesis of age-related macular degeneration (AMD), but the specific mechanisms are incompletely understood. Complement also potentiates retinal degeneration in the murine light damage model. To te
Externí odkaz:
https://doaj.org/article/8ce85ffb9f814883bd1cf53766c779c5
Autor:
Fangyuan Gao, Emily Tom, Stephanie A. Lieffrig, Silvia C. Finnemann, Dorota Skowronska-Krawczyk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionThe vertebrate retinal pigment epithelium (RPE) lies adjacent to the photoreceptors and is responsible for the engulfment and degradation of shed photoreceptor outer segment fragments (POS) through receptor-mediated phagocytosis. Phagocyt
Externí odkaz:
https://doaj.org/article/bfc1cc3bb8ac44d3b57181b2619161f1
Autor:
Francesca Mazzoni, Claudia Müller, Jonathan DeAssis, Deborah Lew, W. Matthew Leevy, Silvia C. Finnemann
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by apoptosis. Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(
Externí odkaz:
https://doaj.org/article/b9a3c646aa1d4bb2a8a8cbe6cc25c001
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101918- (2021)
Methionine sulfoxide reductase A (MsrA) is a widely expressed antioxidant enzyme that counteracts oxidative protein damage and contributes to protein regulation by reversing oxidation of protein methionine residues. In retinal pigment epithelial (RPE
Externí odkaz:
https://doaj.org/article/0efcf6d862c644fc828b83acea40accc
Autor:
Yingyu Mao, Silvia C. Finnemann
Publikováno v:
Cells, Vol 10, Iss 8, p 1927 (2021)
The diurnal phagocytosis of spent photoreceptor outer segment fragments (POS) by retinal pigment epithelial (RPE) cells is essential for visual function. POS internalization by RPE cells requires the assembly of F-actin phagocytic cups beneath surfac
Externí odkaz:
https://doaj.org/article/93de55d26ed74963a9d9a431227b67c3
Autor:
Birgit Ploier, Lydia N. Caro, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, Johannes Graumann, Vadim Y. Arshavsky, Jeremy S. Dittman, Oliver P. Ernst, Anant K. Menon
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Retinitis pigmentosa is often caused by mutations that affect the activity or transport of rhodopsin, but some mutations cause disease even though an apparently functional protein is produced. Here the authors show that three such enigmatic mutants r
Externí odkaz:
https://doaj.org/article/94c82e6657484b44baee46822dc7c91b
Autor:
Maria E. Mercau, Yemsratch T. Akalu, Francesca Mazzoni, Gavin Gyimesi, Emily J. Alberto, Yong Kong, Brian P. Hafler, Silvia C. Finnemann, Carla V. Rothlin, Sourav Ghosh
Publikováno v:
Science Advances. 9
Severe, early-onset photoreceptor (PR) degeneration associated with MERTK mutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR degeneration in mouse models of Mertk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b42c318288bf169f3d5c6a2d29414d52
https://doi.org/10.1126/sciadv.ade9459
https://doi.org/10.1126/sciadv.ade9459
Autor:
Maria E. Mercau, Yemsratch T. Akalu, Francesca Mazzoni, Gavin Gyimesi, Emily Alberto, Yong Kong, Brian P. Hafler, Silvia C. Finnemann, Carla V. Rothlin, Sourav Ghosh
Severe, early-onset photoreceptor (PR) degeneration associated withMERTKmutations is thought to result from failed phagocytosis by retinal pigment epithelium (RPE). Notwithstanding, the severity and onset of PR degeneration in mouse models ofMertkabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e5479698bc1fa337abdcd0327518be0
https://doi.org/10.1101/2022.10.08.511415
https://doi.org/10.1101/2022.10.08.511415
Autor:
Maria E Mercau, Yemsratch T Akalu, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Publikováno v:
eLife. 11
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ece70fa123e16444e933940c257894f1
https://doi.org/10.7554/elife.80530
https://doi.org/10.7554/elife.80530