Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Silvia C Finnemann"'
Autor:
Fangyuan Gao, Emily Tom, Stephanie A. Lieffrig, Silvia C. Finnemann, Dorota Skowronska-Krawczyk
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionThe vertebrate retinal pigment epithelium (RPE) lies adjacent to the photoreceptors and is responsible for the engulfment and degradation of shed photoreceptor outer segment fragments (POS) through receptor-mediated phagocytosis. Phagocyt
Externí odkaz:
https://doaj.org/article/bfc1cc3bb8ac44d3b57181b2619161f1
Autor:
Devin Rocks, Mamta Shukla, Laila Ouldibbat, Silvia C. Finnemann, Achyuth Kalluchi, M. Jordan Rowley, Marija Kundakovic
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Here the authors provide evidence that 3D chromatin structure in the mouse brain differs between males and females and undergoes dynamic remodelling during the female ovarian cycle. They show female-specific 3D genome dynamics affects neuronal gene e
Externí odkaz:
https://doaj.org/article/202b6f36f95a42a1a01547b4b2b59f11
Autor:
Yemsratch T Akalu, Maria E Mercau, Marleen Ansems, Lindsey D Hughes, James Nevin, Emily J Alberto, Xinran N Liu, Li-Zhen He, Diego Alvarado, Tibor Keler, Yong Kong, William M Philbrick, Marcus Bosenberg, Silvia C Finnemann, Antonio Iavarone, Anna Lasorella, Carla V Rothlin, Sourav Ghosh
Publikováno v:
eLife, Vol 11 (2022)
Knockout (KO) mouse models play critical roles in elucidating biological processes behind disease-associated or disease-resistant traits. As a presumed consequence of gene KO, mice display certain phenotypes. Based on insight into the molecular role
Externí odkaz:
https://doaj.org/article/43fad56f4e26479584968f8d6e15f037
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 16 (2022)
Clearance phagocytosis is a documented function of Müller glia in the retina. However, the molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show that extracellular galectin-3 and protein S promote clearance phagoc
Externí odkaz:
https://doaj.org/article/ba3f7702055948efb2ecc083f074bcc1
Autor:
Francesca Mazzoni, Claudia Müller, Jonathan DeAssis, Deborah Lew, W. Matthew Leevy, Silvia C. Finnemann
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
Abstract Phosphatidylserine externalization is an early molecular signature for apoptosis. In many retinal degenerative diseases, photoreceptor neurons die by apoptosis. Here, we report utility of the phosphatidylserine-binding conjugate of Bis(zinc(
Externí odkaz:
https://doaj.org/article/b9a3c646aa1d4bb2a8a8cbe6cc25c001
Publikováno v:
Redox Biology, Vol 42, Iss , Pp 101918- (2021)
Methionine sulfoxide reductase A (MsrA) is a widely expressed antioxidant enzyme that counteracts oxidative protein damage and contributes to protein regulation by reversing oxidation of protein methionine residues. In retinal pigment epithelial (RPE
Externí odkaz:
https://doaj.org/article/0efcf6d862c644fc828b83acea40accc
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Retinitis Pigmentosa (RP) is a group of inherited retinal diseases characterized by progressive loss of rod followed by cone photoreceptors. An especially early onset form of RP with blindness in teenage years is caused by mutations in mertk, the gen
Externí odkaz:
https://doaj.org/article/3af224a5d28b4781ad42af6015f1e145
Publikováno v:
Stem Cell Reports, Vol 10, Iss 3, Pp 1075-1087 (2018)
Summary: With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is imperative. Phagocytosis of photoreceptor outer segment fragments (POS) is a key indic
Externí odkaz:
https://doaj.org/article/e0deed6eaa174a379b7eaf16ce4e4796
Autor:
Richard J. Davis, Nazia M. Alam, Cuiping Zhao, Claudia Müller, Janmeet S. Saini, Timothy A. Blenkinsop, Francesca Mazzoni, Melissa Campbell, Susan M. Borden, Carol J. Charniga, Patty L. Lederman, Vanessa Aguilar, Michael Naimark, Michael Fiske, Nathan Boles, Sally Temple, Silvia C. Finnemann, Glen T. Prusky, Jeffrey H. Stern
Publikováno v:
Stem Cell Reports, Vol 9, Iss 1, Pp 42-49 (2017)
Age-related macular degeneration (AMD) is a common cause of central visual loss in the elderly. Retinal pigment epithelial (RPE) cell loss occurs early in the course of AMD and RPE cell transplantation holds promise to slow disease progression. We re
Externí odkaz:
https://doaj.org/article/2f04f00793cb4317b5d4af57e00a3b05
Autor:
Yingyu Mao, Silvia C. Finnemann
Publikováno v:
Cells, Vol 10, Iss 8, p 1927 (2021)
The diurnal phagocytosis of spent photoreceptor outer segment fragments (POS) by retinal pigment epithelial (RPE) cells is essential for visual function. POS internalization by RPE cells requires the assembly of F-actin phagocytic cups beneath surfac
Externí odkaz:
https://doaj.org/article/93de55d26ed74963a9d9a431227b67c3