Zobrazeno 1 - 10
of 144
pro vyhledávání: '"Silvia Bulfone Paus"'
Autor:
Elisabeth Kleeblatt, Pia Lazki-Hagenbach, Ellon Nabet, Reli Cohen, Rajia Bahri, Nicholas Rogers, Abigail Langton, Silvia Bulfone-Paus, Dan Frenkel, Ronit Sagi-Eisenberg
Publikováno v:
Immunity & Ageing, Vol 21, Iss 1, Pp 1-22 (2024)
Abstract Background Mast cells (MCs) are tissue resident cells of the immune system, mainly known for their role in allergy. However, mounting evidence indicates their involvement in the pathology of age-related diseases, such as Alzheimer’s diseas
Externí odkaz:
https://doaj.org/article/8ab567573ae24018a1bb940b83022af0
Autor:
Peter W. West, Jérémy Chéret, Rajia Bahri, Orsolya Kiss, Zining Wu, Colin H. Macphee, Silvia Bulfone-Paus
Publikováno v:
iScience, Vol 27, Iss 10, Pp 110984- (2024)
Summary: Mast cells (MCs) are tissue-resident immune cells known to degranulate in response to FcεRI crosslinking or MRGPRX2 engagement. MCs are found close to nerves, but the mechanisms that regulate this privileged localization remain unclear. Her
Externí odkaz:
https://doaj.org/article/0ebe03746b034342af49104ab4d42dd5
Autor:
Peter W. West, Chiara Tontini, Haris Atmoko, Orsolya Kiss, Terence Garner, Rajia Bahri, Richard B. Warren, Christopher E. M. Griffiths, Adam Stevens, Silvia Bulfone-Paus
Publikováno v:
Cells, Vol 12, Iss 17, p 2177 (2023)
Mast cells (MCs) contribute to skin inflammation. In psoriasis, the activation of cutaneous neuroimmune networks commonly leads to itch. To dissect the unique contribution of MCs to the cutaneous neuroinflammatory response in psoriasis, we examined t
Externí odkaz:
https://doaj.org/article/238c43347a2a4ea4bd312259b902c496
Autor:
Karen Magdalena Garcia-Rodriguez, Estela Isabel Bini, Armando Gamboa-Domínguez, Clara Inés Espitia-Pinzón, Sara Huerta-Yepez, Silvia Bulfone-Paus, Rogelio Hernández-Pando
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Tuberculosis (TB) is still a major worldwide health threat and primarily a lung disease. The innate immune response against Mycobacterium tuberculosis (Mtb) is orchestrated by dendritic cells, macrophages, neutrophils, natural killer cells a
Externí odkaz:
https://doaj.org/article/c2a45d9a534d4e06a1b51636fd77f89a
Autor:
Peter W. West, Silvia Bulfone-Paus
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Mast cells occupy a unique niche within tissues as long lived perpetrators of IgE mediated hypersensitivity and anaphylaxis, as well as other immune responses. However, mast cells are not identical in different tissues and the impact of this tissue h
Externí odkaz:
https://doaj.org/article/d6cf161d294f406cae3454f84900cace
Autor:
Rajia Bahri, Orsolya Kiss, Ian Prise, Karen M. Garcia-Rodriguez, Haris Atmoko, Julia M. Martínez-Gómez, Mitchell P. Levesque, Reinhard Dummer, Michael P. Smith, Claudia Wellbrock, Silvia Bulfone-Paus
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Cutaneous melanoma is one of the most aggressive human malignancies and shows increasing incidence. Mast cells (MCs), long-lived tissue-resident cells that are particularly abundant in human skin where they regulate both innate and adaptive immunity,
Externí odkaz:
https://doaj.org/article/65e963f136964a6b9f153b7ea594d82a
Autor:
Karen M. Garcia‐Rodriguez, Rajia Bahri, Clara Sattentau, Ian S. Roberts, Anu Goenka, Silvia Bulfone‐Paus
Publikováno v:
Immunity, Inflammation and Disease, Vol 8, Iss 2, Pp 198-210 (2020)
Abstract Introduction Mast cells (MCs) are tissue‐resident immune cells implicated in antibacterial responses. These include chemokine secretion, degranulation, and the release of mast cell‐extracellular traps, which are primarily dependent on re
Externí odkaz:
https://doaj.org/article/addd3c1755484f47b28132f39ca7c9b3
Autor:
Chiara Tontini, Silvia Bulfone-Paus
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Allergy is an IgE-dependent type-I hypersensitivity reaction that can lead to life-threatening systemic symptoms such as anaphylaxis. In the pathogenesis of the allergic response, the common upstream event is the binding of allergens to specific IgE,
Externí odkaz:
https://doaj.org/article/0104119481494a2d9b15e7f9fd3f88e8
Autor:
Peter W. West, Rajia Bahri, Karen M. Garcia-Rodriguez, Georgia Sweetland, Georgia Wileman, Rajesh Shah, Angeles Montero, Laura Rapley, Silvia Bulfone-Paus
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Both, aberrant mast cell responses and complement activation contribute to allergic diseases. Since mast cells are highly responsive to C3a and C5a, while Interleukin-33 (IL-33) is a potent mast cell activator, we hypothesized that IL-33 critically r
Externí odkaz:
https://doaj.org/article/672dda23f48f4131b381099478484ab5
Publikováno v:
Cells, Vol 10, Iss 9, p 2282 (2021)
Localisation of mast cells (MCs) at the abluminal side of blood vessels in the brain favours their interaction with glial cells, neurons, and endothelial cells, resulting in the activation of these cells and the release of pro-inflammatory mediators.
Externí odkaz:
https://doaj.org/article/28edd23a82fc4b8db07e99cf5abc7ddd