Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Silvia Bovolenta"'
Autor:
Marica Gemei, Carmine Talarico, Laura Brandolini, Candida Manelfi, Lorena Za, Silvia Bovolenta, Chiara Liberati, Luigi Del Vecchio, Roberto Russo, Carmen Cerchia, Marcello Allegretti, Andrea Rosario Beccari
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 20, p 7677 (2020)
The kinin B1 receptor plays a critical role in the chronic phase of pain and inflammation. The development of B1 antagonists peaked in recent years but almost all promising molecules failed in clinical trials. Little is known about these molecules’
Externí odkaz:
https://doaj.org/article/0f2eb9388363498d89f803b9ca3a0b9c
Autor:
Andrea Aramini, Silvia Bovolenta, Chiara Liberati, Lorena Za, Gianluca Bianchini, Mara Tomassetti, Samuele Lillini, Rubina Novelli, Anna Sirico
Publikováno v:
Journal of Medicinal Chemistry. 64:16820-16837
Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modulation and perception, and TRPM8 antagonists have been proposed as potential therapeutic approaches for pain treatment. Previously, we developed two TRPM8 antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53312ae842dabe5b01fc01282381239f
https://doi.org/10.1021/acs.jmedchem.1c01647
https://doi.org/10.1021/acs.jmedchem.1c01647
Autor:
Gianluca, Bianchini, Mara, Tomassetti, Samuele, Lillini, Anna, Sirico, Silvia, Bovolenta, Lorena, Za, Chiara, Liberati, Rubina, Novelli, Andrea, Aramini
Publikováno v:
Journal of medicinal chemistry. 64(22)
Transient receptor potential melastatin 8 (TRPM8) is crucially involved in pain modulation and perception, and TRPM8 antagonists have been proposed as potential therapeutic approaches for pain treatment. Previously, we developed two TRPM8 antagonists
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c329633b95fd021ee39822e7b19452b5
https://pubmed.ncbi.nlm.nih.gov/34762442
https://pubmed.ncbi.nlm.nih.gov/34762442
Autor:
Chiara Liberati, Luigi Del Vecchio, Lorena Za, Andrea R. Beccari, Laura Brandolini, Marcello Allegretti, Candida Manelfi, Marica Gemei, Carmen Cerchia, Carmine Talarico, Roberto Russo, Silvia Bovolenta
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 7677, p 7677 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences
Volume 21
Issue 20
The kinin B1 receptor plays a critical role in the chronic phase of pain and inflammation. The development of B1 antagonists peaked in recent years but almost all promising molecules failed in clinical trials. Little is known about these molecules&rs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2162b531022cecc9cccfa0656d79357
https://www.mdpi.com/1422-0067/21/20/7677
https://www.mdpi.com/1422-0067/21/20/7677
Autor:
Alessandro Taddei, Lorena Za, Giulio Vistoli, Marica Gemei, Andrea Rossignoli, Cinzia Nucci, Andrea R. Beccari, Nazareno Menegatti, Chiara Liberati, Matteo Lo Monte, Silvia Bovolenta, Laura Brandolini, Marco Fanton, Alessandro Pedretti, Angela Molteni
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Transient receptor potential melastatin 8 (TRPM8), a nonselective cation channel, is the predominant mammalian cold temperature thermosensor and it is activated by cold temperatures and cooling compounds, such as menthol and icilin. Because of its ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73294ad0816876d42d2fcd6061b8d7fc
http://link.springer.com/article/10.1038/s41598-017-11194-0
http://link.springer.com/article/10.1038/s41598-017-11194-0
Autor:
Rocco Vitalone, Silvia Bovolenta, Elda Severi, Lorena Za, Paola Tarroni, Domenica Torino, Paolo Pevarello
Publikováno v:
Pharmaceutical Patent Analyst. 6:61-76
P2X7, a ligand-gated purinergic ion channel, has been at the center of intense efforts in the pharmaceutical industry in the last 15 years due to the growing appreciation of its role in inflammation. Since 2008–2009, increased focus on CNS availabl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582e935f78e1c70c71e59adc439e0383
https://doi.org/10.4155/ppa-2016-0044
https://doi.org/10.4155/ppa-2016-0044
Autor:
Angela Molteni, Alessandro Pedretti, Giulio Vistoli, Marica Gemei, Cinzia Nucci, Alessandro Taddei, Nazareno Menegatti, Andrea R. Beccari, Marco Fanton, Lorena Za, Laura Brandolini, Andrea Rossignoli, Matteo Lo Monte, Silvia Bovolenta, Chiara Liberati
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6d459b8e5498db14e18130335dd1bf
https://doi.org/10.1038/s41598-018-21902-z
https://doi.org/10.1038/s41598-018-21902-z
Autor:
Silvia Cainarca, Sabrina Corazza, Silvia Bovolenta, Simone Fenu, Andrea Menegon, Patrizia Arioli, Stefan Lohmer
Publikováno v:
SLAS Discovery. 15:1132-1143
The use of engineered mouse embryonic stem (mES) cells in high-throughput screening (HTS) can offer new opportunities for studying complex targets in their native environment, increasing the probability of discovering more meaningful hits. The author
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36f7e7c7bda34594538fd7cbbe88b342
https://doi.org/10.1177/1087057110379267
https://doi.org/10.1177/1087057110379267
Publikováno v:
SLAS Discovery. 12:694-704
The present work describes the engineering and characterization of a new Ca(2+)-activated photoprotein (Photina) and its use in mammalian cell lines for implementation of flash luminescence cell-based assays for high-throughput screening (HTS). When
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb12bac86b297563919d02fa0dca82cc
https://doi.org/10.1177/1087057107301497
https://doi.org/10.1177/1087057107301497
Autor:
Fabio Benigni, Laura Brandolini, Arianna Bettiga, Andrea Russo, Petter Hedlund, Roberto Russo, Marcello Allegretti, Silvia Bovolenta, Fabio Castiglione, Francesco Montorsi, Giorgia Colciago, Francesco A. Mistretta, Gianluca Bianchini, Andrea Aramini
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 356(1)
The transient receptor potential melastin 8 ion channel (TRPM8) is implicated in bladder sensing but limited information on TRPM8 antagonists in bladder overactivity is available. This study characterizes a new TRPM8-selective antagonist (DFL23448 [5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbf2b07b058d4bcab0a0dd6fb882a3d5
https://pubmed.ncbi.nlm.nih.gov/26546575
https://pubmed.ncbi.nlm.nih.gov/26546575