Expression of Dectin-1 and Enhanced Activation of NALP3 Inflammasome Are Associated with Resistance to Paracoccidioidomycosis

Autor: Vera Lucia Garcia Calich, Claudia eFeriotti, Silvia B. Bazan, Flavio Vieira Loures, Eliseu Frank Araujo, Tania A. Costa

Publikováno v: Frontiers in Microbiology, Vol 6 (2015)

Dectin-1 is a pattern recognition receptor (PRR) that recognizes β-glucans and plays a major role in the immunity against fungal pathogens. Paracoccidioides brasiliensis, the causative agent of paracoccidioidomycosis, has a sugar-rich cell wall main

Externí odkaz: https://doaj.org/article/df217e2d80594dba9d674c0eb59a48df

Anti-CD25 treatment depletes Treg cells and decreases disease severity in susceptible and resistant mice infected with Paracoccidioides brasiliensis.

Autor: Maíra Felonato, Adriana Pina, Eliseu Frank de Araujo, Flávio V Loures, Silvia B Bazan, Cláudia Feriotti, Vera L G Calich

Publikováno v: PLoS ONE, Vol 7, Iss 11, p e51071 (2012)

Regulatory T (Treg) cells are fundamental in the control of immunity and excessive tissue pathology. In paracoccidioidomycosis, an endemic mycosis of Latin America, the immunoregulatory mechanisms that control the progressive and regressive forms of

Externí odkaz: https://doaj.org/article/7ff8499cdcbb4a9ebf668eae15cf10a0

TLR-4 cooperates with Dectin-1 and mannose receptor to expand Th17 and Tc17 cells induced by Paracoccidioides brasiliensis stimulated dendritic cells

Autor: Claudia Feriotti, Silvia B. Bazan, Eliseu Frank de Araújo, Flávio V. Loures, Vera Lúcia Garcia Calich

Publikováno v: Frontiers in Microbiology
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Frontiers in Microbiology, Vol 6 (2015)

The concomitant use of diverse pattern recognition receptors (PRRs) by innate immune cells can result in synergistic or inhibitory activities that profoundly influence anti-microbial immunity. Dectin-1 and the mannose receptor (MR) are C-type lectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41225b28792162df6ba8c70f10abb714

Loss- and gain-of-function approaches indicate a dual role exerted by regulatory T cells in pulmonary paracoccidioidomycosis

Autor: Eliseu Frank de Araújo, Silvia B. Bazan, Flávio V. Loures, Claudia Feriotti, Vera Lúcia Garcia Calich, Tania Alves da Costa, Fernando Delgado Pretel

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 9, Iss 10, p e0004189 (2015)

Paracoccidioidomycosis (PCM), is a pulmonary fungal disease whose severity depends on the adequate development of T cell immunity. Although regulatory T (Treg) cells were shown to control immunity against PCM, deleterious or protective effects were d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67effa6a1c08e833772cb645ca75bf98

Dectin-1 induces M1 macrophages and prominent expansion of CD8+IL-17+ cells in pulmonary Paracoccidioidomycosis

Autor: Eliseu Frank de Araújo, Flávio V. Loures, Vera Lúcia Garcia Calich, Silvia B. Bazan, Tânia Alves da Costa, Gordon D. Brown, Claudia Feriotti

Publikováno v: Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP

Dectin-1, the innate immune receptor that recognizes β-glucan, plays an important role in immunity against fungal pathogens. Paracoccidioides brasiliensis, the etiological agent of paracoccidioidomycosis, has a sugar-rich cell wall mainly composed o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aabcaf4337c100c3db7cc22dc8c818bd
https://pubmed.ncbi.nlm.nih.gov/24604821