Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Silvia B V Ramos"'
Autor:
Lela Lackey, Aaztli Coria, Auyon J Ghosh, Phil Grayeski, Abigail Hatfield, Vijay Shankar, John Platig, Zhonghui Xu, Silvia B V Ramos, Edwin K Silverman, Victor E Ortega, Michael H Cho, Craig P Hersh, Brian D Hobbs, Peter Castaldi, Alain Laederach
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Externí odkaz:
https://doaj.org/article/a9364620e0274197ae0b0ec2bcff504b
Autor:
Christopher B Ball, Karina F Rodriguez, Deborah J Stumpo, Fernando Ribeiro-Neto, Kenneth S Korach, Perry J Blackshear, Lutz Birnbaumer, Silvia B V Ramos
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97324 (2014)
ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in the decreased expression of a form of ZFP36L2 in which the 29 N-terminal
Externí odkaz:
https://doaj.org/article/f8c33bcbd7734d5498926a45604a8cbe
Autor:
Ian C Redmon, Matthew Ardizzone, Hilal Hekimoğlu, Breanne M Hatfield, Justin M Waldern, Abhishek Dey, Stephanie A Montgomery, Alain Laederach, Silvia B V Ramos
Publikováno v:
Nucleic acids research. 50(7)
Zinc finger protein 36 like 2 (ZFP36L2) is an RNA-binding protein that destabilizes transcripts containing adenine-uridine rich elements (AREs). The overlap between ZFP36L2 targets in different tissues is minimal, suggesting that ZFP36L2-targeting is
Autor:
Edwin K. Silverman, Phil Grayeski, Brian D. Hobbs, Craig P. Hersh, Peter J. Castaldi, Aaztli Coria, Silvia B. V. Ramos, Zhonghui Xu, Victor E Ortega, Michael H. Cho, Lela Lackey, Alain Laederach, John Platig, Vijay Shankar, Auyon J. Ghosh, Luke Hatfield
Publikováno v:
PLoS Genetics, Vol 17, Iss 11, p e1009912 (2021)
PLoS Genetics
PLoS Genetics
α1-anti-trypsin (A1AT), encoded by SERPINA1, is a neutrophil elastase inhibitor that controls the inflammatory response in the lung. Severe A1AT deficiency increases risk for Chronic Obstructive Pulmonary Disease (COPD), however, the role of A1AT in
Autor:
Sohei Makita, Hiroaki Takatori, Arifumi Iwata, Shigeru Tanaka, Shunsuke Furuta, Kei Ikeda, Akira Suto, Kotaro Suzuki, Silvia B. V. Ramos, Hiroshi Nakajima
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Frontiers in Immunology
Frontiers in Immunology
The zinc finger protein 36-like 2, ZFP36L2, is a member of a small family of RNA-binding proteins composed by ZFP36 (also known as tristetraprolin, TTP), ZFP36L1 and ZFP36L2 in humans, with corresponding murine orthologs. These proteins bind to adeni
Publikováno v:
Nucleic Acids Research
Designing novel RNA topologies is a challenge, with important therapeutic and industrial applications. We describe a computational pipeline for design of novel RNA topologies based on our coarse-grained RNA-As-Graphs (RAG) framework. RAG represents R
Publikováno v:
RNA. 23:1209-1223
ZFP36L2 (L2) destabilizes AU-rich element (ARE)-containing transcripts and has been implicated in female fertility. We have shown that only one of three putative AREs within the 3′ UTR of murine luteinizing hormone receptor mRNA, ARE2197 (UAUUUAU),
Publikováno v:
Wiley Interdisciplinary Reviews: RNA. 6:517-532
RNA conformation plays a significant role in stability, ligand binding, transcription, and translation. Single nucleotide variants (SNVs) have the potential to disrupt specific structural elements because RNA folds in a sequence-specific manner. A ri
Autor:
Heather A. Vincent, Meredith Corley, Gabriela Phillips, Anthony M. Mustoe, Nathaniel J. Moorman, Amanda Solem, Kevin M. Weeks, Silvia B. V. Ramos, Lela Lackey, Alain Laederach, Benjamin Ziehr
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Protein and mRNA expression are in most cases poorly correlated, which suggests that the posttranscriptional regulatory program of a cell is an important component of gene expression. This regulatory network is still poorly understood, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b696410b089533b0c9059496d6d93c06
Autor:
Nathaniel J. Moorman, Erin K. Borchardt, Silvia B. V. Ramos, Rita M. Meganck, Christopher B. Ball, William F. Marzluff, Heather A. Vincent, Aravind Asokan
Circular RNAs (circRNAs) are highly stable, covalently closed RNAs that are regulated in a spatiotemporal manner and whose functions are largely unknown. These molecules have the potential to be incorporated into engineered systems with broad technol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6cc9eeb50bdf92302f9d9ef67941c4