Výsledky vyhledávání - "Silvia Avino"

The Effect of Curcumin on Idiopathic Parkinson Disease: A Clinical and Skin Biopsy Study

Autor: Vincenzo Donadio, Alex Incensi, Giovanni Rizzo, Enrico Fileccia, Francesco Ventruto, Antonella Riva, Domenico Tiso, Martino Recchia, Veria Vacchiano, Rossella Infante, Giovanna Petrangolini, Pietro Allegrini, Silvia Avino, Roberta Pantieri, Barbara Mostacci, Patrizia Avoni, Rocco Liguori

There are currently no standardized therapies for Parkinson disease (PD). Curcumin shows anti-amyloidogenic properties in vitro and may be a promising treatment for PD. We evaluated the effects of curcumin supplementation on clinical scales and misfo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e646409de3740fb5459e36b0f438f179
https://hdl.handle.net/11585/897697

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GPER is involved in the regulation of the estrogen-metabolizing CYP1B1 enzyme in breast cancer

Autor: Luigina Muto, Rocco Malivindi, Silvia Avino, Michele Pellegrino, Anna Sebastiani, Marcello Maggiolini, Paola De Marco, Francesca Cirillo, Miki Nakajima, Rosamaria Lappano, Sergio Abonante, Vincenza Dolce, Vittoria Rago, Damiano Cosimo Rigiracciolo, Adele Vivacqua

Publikováno v: Oncotarget

The cytochrome P450 1B1 (CYP1B1) is a heme-thiolate monooxygenase involved in both estrogen biosynthesis and metabolism. For instance, CYP1B1 catalyzes the hydroxylation of E2 leading to the production of 4-hydroxyestradiol that may act as a potent c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23b743329c0a930191376f457e475af5
https://doi.org/10.18632/oncotarget.22541

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Protective Role of GPER Agonist G-1 on Cardiotoxicity Induced by Doxorubicin

Autor: Teresa Pasqua, Ernestina Marianna De Francesco, Daniela Amelio, Silvia Avino, Francesca Cirillo, Nicola Amodio, Maria Carmela Cerra, Marcello Maggiolini, Tommaso Angelone, Carmine Rocca, F. Scavello, Damiano Cosimo Rigiracciolo, Andrea Scarpelli

Publikováno v: Journal of Cellular Physiology. 232:1640-1649

The use of Doxorubicin (Dox), a frontline drug for many cancers, is often complicated by dose-limiting cardiotoxicity in approximately 20% of patients. The G-protein estrogen receptor GPER/GPR30 mediates estrogen action as the cardioprotection under

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16258578216f280adca6d494582b9b0a
https://doi.org/10.1002/jcp.25585

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Recent Advances on the Role of G Protein-Coupled Receptors in Hypoxia-Mediated Signaling

Autor: Ernestina Marianna De Francesco, Marcello Maggiolini, Camillo Rosano, Rosamaria Lappano, Damiano Cosimo Rigiracciolo, Anna Rita Cappello, Paola De Marco, Silvia Avino

Publikováno v: The AAPS Journal. 18:305-310

G protein-coupled receptors (GPCRs) are cell surface proteins mainly involved in signal transmission; however, they play a role also in several pathophysiological conditions. Chemically heterogeneous molecules like peptides, hormones, lipids, and neu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bd019d7704fb40099823272f0b60a0e
https://doi.org/10.1208/s12248-016-9881-6

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Identification of two benzopyrroloxazines acting as selective GPER antagonists in breast cancer cells and cancer-associated fibroblasts

Autor: Camillo Rosano, Marcello Maggiolini, Fedora Grande, Francesca Aiello, Maria Francesca Santolla, Antonio Garofalo, Silvia Avino

Publikováno v: Future Medicinal Chemistry. 7:437-448

Background: G-protein coupled estrogen receptor (GPER) is involved in numerous intracellular physiological and pathological events including cancer cell migration and proliferation. Its characterization is yet incomplete due to the limited number of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a1ea727876f94104d522df992d43458
https://doi.org/10.4155/fmc.15.3

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Genetic evidence that β-arrestins are dispensable for the initiation of β

Autor: Morgan, O'Hayre, Kelsie, Eichel, Silvia, Avino, Xuefeng, Zhao, Dana J, Steffen, Xiaodong, Feng, Kouki, Kawakami, Junken, Aoki, Karen, Messer, Roger, Sunahara, Asuka, Inoue, Mark, von Zastrow, J Silvio, Gutkind

Publikováno v: Science signaling. 10(484)

The β2 adrenergic receptor (β2AR) has provided a paradigm to elucidate how G protein-coupled receptors (GPCRs) control intracellular signaling, including the discovery that β-arrestins, which bind to ligand-activated GPCRs, are central for GPCR fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::66adcb7588ead04346a867a229144f3a
https://pubmed.ncbi.nlm.nih.gov/28634209

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Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK

Autor: Morgan O'Hayre, Mark von Zastrow, Xiaodong Feng, Asuka Inoue, J. Silvio Gutkind, Kouki Kawakami, Silvia Avino, Dana J. Steffen, Karen Messer, Kelsie Eichel, Xuefeng Zhao, Junken Aoki, Roger K. Sunahara

Publikováno v: Science Signaling. 10

The β2-adrenergic receptor (β2AR) has provided a paradigm to elucidate how G protein-coupled receptors (GPCRs) control intracellular signaling, including the discovery that β-arrestins, which bind to ligand-activated GPCRs, are central for GPCR fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::542bc2efe3209a8455ce7939c63cc382
https://doi.org/10.1126/scisignal.aal3395

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GPER signalling in both cancer-associated fibroblasts and breast cancer cells mediates a feedforward IL1β/IL1R1 response

Autor: Marco Pupo, Francesca Cirillo, Paola De Marco, Marcello Maggiolini, Ernestina Marianna De Francesco, Adele Vivacqua, Sergio Abonante, Didier Picard, Rosamaria Lappano, Silvia Avino

Publikováno v: Scientific Reports, Vol. 6 (2016)
Scientific Reports
Sci. Rep.

Cancer-associated fibroblasts (CAFs) contribute to the malignant aggressiveness through secreted factors like IL1β, which may drive pro-tumorigenic inflammatory phenotypes mainly acting via the cognate receptor named IL1R1. Here, we demonstrate that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dfde9f527d2ec7e235935cbb7f40a1
https://doi.org/10.1038/srep24354

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Stimulatory actions of IGF-I are mediated by IGF-IR cross-talk with GPER and DDR1 in mesothelioma and lung cancer cells

Autor: Maria Grazia Perri, Maria Francesca Santolla, Silvia Avino, Francesca Cirillo, Marcello Maggiolini, Ernestina Marianna De Francesco, Paola De Marco, Adele Vivacqua, Rosamaria Lappano, Vincenza Dolce, Damiano Cosimo Rigiracciolo, Antonino Belfiore

Publikováno v: Oncotarget

Insulin-like growth factor-I (IGF-I)/IGF-I receptor (IGF-IR) system has been largely involved in the pathogenesis and development of various tumors. We have previously demonstrated that IGF-IR cooperates with the G-protein estrogen receptor (GPER) an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::582d950a9ba4fde6da87778e7fa55d2d
https://pubmed.ncbi.nlm.nih.gov/27384677

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GPER is involved in the stimulatory effects of aldosterone in breast cancer cells and breast tumor-derived endothelial cells

Autor: Andrea Scarpelli, Assunta Pisano, Rosamaria Lappano, Maria Francesca Santolla, Ernestina Marianna De Francesco, Benedetta Bussolati, Paola De Marco, Damiano Cosimo Rigiracciolo, Marcello Maggiolini, Silvia Avino

Publikováno v: Oncotarget
Scopus-Elsevier

// Damiano Cosimo Rigiracciolo 1 , Andrea Scarpelli 1 , Rosamaria Lappano 1 , Assunta Pisano 1 , Maria Francesca Santolla 1 , Silvia Avino 1 , Paola De Marco 1 , Benedetta Bussolati 2 , Marcello Maggiolini 1 and Ernestina Marianna De Francesco 1 1 De

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4705872de42f05b319f1e35d0ac256e1
http://hdl.handle.net/20.500.11769/507379

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