Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity

Autor: Valentina Salvi, Carolina Gaudenzi, Barbara Mariotti, Gaia Giongrandi, Silvia Alacqua, Veronica Gianello, Tiziana Schioppa, Laura Tiberio, Angela Ceribelli, Carlo Selmi, Paolo Bergese, Stefano Calza, Annalisa Del Prete, Silvano Sozzani, Flavia Bazzoni, Daniela Bosisio

Publikováno v: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-16 (2024)

Abstract Background The physiological relevance of cell-to-cell communication mediated by small extracellular vesicle-encapsulated microRNAs (sEV-miRNAs) remains debated because of the limiting representativity of specific miRNAs within the extracell

Externí odkaz: https://doaj.org/article/314b902687d6416e8812b09c4914d5db

Assessing the effect of protein corona formation in the process of EV surface engineering

Autor: Angelo Musicò, Rossella Zenatelli, Miriam Romano, Andrea Zendrini, Silvia Alacqua, Selene Tassoni, Lucia Paolini, Chiara Urbinati, Marco Rusnati, Paolo Bergese, Giuseppe Pomarico, Annalisa RADEGHIERI

To be profitably exploited in medicine as drug delivery carriers, nanosized systems should be endowed with essential properties, including high biocompatibility, stealth ability to escape the immune system, prolonged circulation lifetime, and targeti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20ccf3d00d30d90a13d37460a436f863
https://doi.org/10.26434/chemrxiv-2023-rh5s8

Active antithrombin glycoforms are selectively physiosorbed on plasma extracellular vesicles

Autor: Vanessa Previcini, Giuliana Martini, Paolo Bergese, Doris Ricotta, Silvia Alacqua, Annalisa Radeghieri, Andrea Zendrini, Francesca Todaro

Antithrombin (AT) is a glycoprotein produced by the liver and a principal antagonist of active clotting proteases. A deficit in AT function leads to AT qualitative deficiency, challenging to diagnose. Here we report that active AT may travel physioso

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd230ef63d45cf7dfe2e98c638139549
https://hdl.handle.net/11379/565662

Cell damage shifts the microRNA content of small extracellular vesicles into a Toll-like receptor 7-activating cargo capable to propagate inflammation and immunity.

Autor: Salvi, Valentina¹ (AUTHOR), Gaudenzi, Carolina¹ (AUTHOR), Mariotti, Barbara² (AUTHOR), Giongrandi, Gaia¹ (AUTHOR), Alacqua, Silvia¹ (AUTHOR), Gianello, Veronica¹ (AUTHOR), Schioppa, Tiziana^1,3 (AUTHOR), Tiberio, Laura¹ (AUTHOR), Ceribelli, Angela^4,5 (AUTHOR), Selmi, Carlo^4,5 (AUTHOR), Bergese, Paolo¹ (AUTHOR), Calza, Stefano¹ (AUTHOR), Del Prete, Annalisa^1,3 (AUTHOR), Sozzani, Silvano⁶ (AUTHOR), Bazzoni, Flavia² (AUTHOR), Bosisio, Daniela¹ (AUTHOR) daniela.bosisio@unibs.it

Publikováno v: Cell Communication & Signaling. 11/8/2024, Vol. 22 Issue 1, p1-16. 16p.

Findings from University of Brescia in the Area of Nanoparticles Described (Surface Functionalization of Extracellular Vesicle Nanoparticles With Antibodies: a First Study On the Protein Corona "variable.").

Publikováno v: Drug Week; 9/22/2023, p604-604, 1p