Tumour-associated antigenic peptides are present in the HLA class I ligandome of cancer cell line derived extracellular vesicles

Autor: Pankaj Kumar, Caitlin Boyne, Sydney Brown, Ayesha Qureshi, Peter Thorpe, Silvia A. Synowsky, Sally Shirran, Simon J. Powis

Publikováno v: ImmunologyREFERENCES. 166(2)

Funding: Breast Cancer Now (Grant Number(s): 2018JulPR1086), Wellcome Trust (GrantNumber(s): 105621/Z/14/Z), Melville Charitable Trust. The recent success of monoclonal antibody checkpoint inhibitor therapies that enhance the ability of CD8+ T cells

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20997311ceb8f4f71a4b11c0cf7a794f
https://pubmed.ncbi.nlm.nih.gov/35318648

Quantitative proteomic profiling of the rat substantia nigra places glial fibrillary acidic protein at the hub of proteins dysregulated during aging: Implications for idiopathic Parkinson’s disease

Autor: Sally L. Shirran, Silvia Anna Synowsky, Heidi R. Fuller, Yolanda Gómez-Gálvez, Monte A. Gates

This work was made possible by generous funding from the Keele University ACORN scheme and Keele University School of Medicine. There is a strong correlation between aging and onset of idiopathic Parkinson's disease, but little is known about whether

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22422fb76e652840da6ce708ea57ec1b
https://eprints.keele.ac.uk/7803/7/jnr.24622.pdf

Identification of putative adhesins and carbohydrate ligands of Lactobacillus paracasei using a combinatorial in silico and glycomics microarray profiling approach

Autor: Benoit Houeix, Marian Kane, Michael T. Cairns, Lokesh Joshi, Michelle Kilcoyne, Silvia Anna Synowsky

Commensal bacteria must colonize host mucosal surfaces to exert health-promoting properties, and bind to gastrointestinal tract (GIT) mucins via their cell surface adhesins. Considerable effort has been directed towards discovery of pathogen adhesins

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f01a750e28d7d486ce652feba0308cf2
http://hdl.handle.net/10379/15666

Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration

Autor: Tunde Peto, Alan J. Stewart, Imre Lengyel, Eszter Emri, Swati Arya, Catherine H. Botting, Sally L. Shirran, Neda Barzegar-Befroei, Silvia Anna Synowsky

Publikováno v: Arya, S, Emri, E, Synowsky, S A, Shirran, S L, Barzegar-Befroei, N, Peto, T, Botting, C H, Lengyel, I & Stewart, A J 2018, ' Quantitative analysis of hydroxyapatite-binding plasma proteins in genotyped individuals with late-stage age-related macular degeneration ', Experimental Eye Research, vol. 172, pp. 21-29 . https://doi.org/10.1016/j.exer.2018.03.023
Experimental Eye Research

We are also grateful to Fight for Sight for financial support (project grant to A.J.S and I.L.; grant ref.: 1586/1587). This research was also supported by “Eye-Risk” a European Union’s Horizon 2020 research and innovation program (grant ref.:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed7faca64f76fd59442547661c79965
https://pure.qub.ac.uk/en/publications/quantitative-analysis-of-hydroxyapatitebinding-plasma-proteins-in-genotyped-individuals-with-latestage-agerelated-macular-degeneration(755f669c-02fe-4a7e-8265-49574e9a3a89).html

The major histocompatibility complex class I immunopeptidome of extracellular vesicles

Autor: Sally L. Shirran, Fiona G. M. Cooke, Simon J. Powis, Catherine H. Botting, Silvia Anna Synowsky, Antony N. Antoniou

This work was funded by the Melville Trust for the Care and Cure of Cancer, Scotland, UK. Extracellular vesicles (EVs) are released by most cell types and have been associated with multiple immunomodulatory functions. MHC class I molecules have cruci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e933e842df1d10001926fdc06fdc08
https://europepmc.org/articles/PMC5641862/