Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Silvia A. Longhi"'
Autor:
Sofia Apodaca, Marco Di Salvatore, Arturo Muñoz-Calderón, María de los Ángeles Curto, Silvia A. Longhi, Alejandro G. Schijman
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 14 (2024)
IntroductionHuman trophoblastic cell lines, such as BeWo, are commonly used in 2D models to study placental Trypanosoma cruzi infections. However, these models do not accurately represent natural infections. Three-dimensional (3D) microtissue culture
Externí odkaz:
https://doaj.org/article/3d3afaec2b9a4937a5a28fa82eddcd9c
Autor:
Arturo A. Muñoz-Calderón, Susana A. Besuschio, Season Wong, Marisa Fernández, Lady J. García Cáceres, Patricia Giorgio, Laura A. Barcan, Cole Markham, Yanwen E. Liu, Belkisyole Alarcón de Noya, Silvia A. Longhi, Alejandro G. Schijman
Publikováno v:
Microorganisms, Vol 10, Iss 5, p 909 (2022)
A loop-mediated isothermal amplification assay was evaluated as a surrogate marker of treatment failure in Chagas disease (CD). A convenience series of 18 acute or reactivated CD patients who received anti-parasitic treatment with benznidazole was se
Externí odkaz:
https://doaj.org/article/7a88547d6b8d414dad31bac60c2efc8e
Autor:
Alejandro Francisco Benatar, Emmaría Danesi, Susana Alicia Besuschio, Santiago Bortolotti, María Luisa Cafferata, Juan Carlos Ramirez, Constanza Lopez Albizu, Karenina Scollo, María Baleani, Laura Lara, Gustavo Agolti, Sandra Seu, Elsa Adamo, Raúl Horacio Lucero, Lucía Irazu, Marcelo Rodriguez, Andrés Poeylaut-Palena, Silvia Andrea Longhi, Mónica Esteva, Fernando Althabe, Federico Rojkin, Jacqueline Bua, Sergio Sosa-Estani, Alejandro Gabriel Schijman
Publikováno v:
EBioMedicine, Vol 69, Iss , Pp 103450- (2021)
Background: Current algorithm for Congenital Chagas Disease (cCD) diagnosis is unsatisfactory due to low sensitivity of the parasitological methods. Moreover, loss to follow-up precludes final serodiagnosis after nine months of life in many cases. A
Externí odkaz:
https://doaj.org/article/41ba911897ef4a729f4226fe5e6aec19
Autor:
Susana A Besuschio, Albert Picado, Arturo Muñoz-Calderón, Diana P Wehrendt, Marisa Fernández, Alejandro Benatar, Zoraida Diaz-Bello, Cecilia Irurtia, Israel Cruz, Joseph M Ndung'u, María L Cafferata, Graciela Montenegro, Sergio Sosa Estani, Raúl H Lucero, Belkisyole Alarcón de Noya, Silvia A Longhi, Alejandro G Schijman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 8, p e0008402 (2020)
A Trypanosoma cruzi Loopamp kit was recently developed as a ready-to-use diagnostic method requiring minimal laboratory facilities. We evaluated its diagnostic accuracy for detection of acute Chagas disease (CD) in different epidemiological and clini
Externí odkaz:
https://doaj.org/article/957c41d6cf8341b38112db105e8a2f81
Autor:
Rodrigo Pimenta Del-Rei, Leonardo Maia Leony, Paola Alejandra Fiorani Celedon, Nilson Ivo Tonin Zanchin, Mitermayer Galvão Dos Reis, Yara de Miranda Gomes, Alejandro Gabriel Schijman, Silvia Andrea Longhi, Fred Luciano Neves Santos
Publikováno v:
PLoS ONE, Vol 14, Iss 4, p e0215623 (2019)
BackgroundLaboratory diagnosis of chronic Chagas disease is a troubling factor due to lack of reference tests. The WHO suggests the use of two distinct commercial serological tests in parallel. The performance of commercial immunoassays might fluctua
Externí odkaz:
https://doaj.org/article/29bcdf85a4ef48cbbb2f81076f09a388
Autor:
Natalia Anahí Juiz, Elkyn Estupiñán, Daniel Hernández, Alejandra Garcilazo, Raúl Chadi, Gisela Morales Sanfurgo, Alejandro Gabriel Schijman, Silvia Andrea Longhi, Clara Isabel González
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007033 (2019)
Several studies have proposed different genetic markers of susceptibility to develop chronic Chagas cardiomyopathy (CCC). Many genes may be involved, each one making a small contribution. For this reason, an appropriate approach for this problematic
Externí odkaz:
https://doaj.org/article/4b43632422ce46a0b72f005f3f230be1
Autor:
Leticia L Niborski, Vanina Grippo, Sonia O Lafón, Gabriela Levitus, Facundo García-Bournissen, Juan C Ramirez, Juan M Burgos, Margarita Bisio, Natalia A Juiz, Vilma Ayala, María Coppede, Verónica Herrera, Crescencia López, Ana Contreras, Karina A Gómez, Juan C Elean, Hugo D Mujica, Alejandro G Schijman, Mariano J Levin, Silvia A Longhi
Publikováno v:
Memorias do Instituto Oswaldo Cruz, Vol 111, Iss 6, Pp 365-371 (2016)
This study aimed to evaluate well-documented diagnostic antigens, named B13, 1F8 and JL7 recombinant proteins, as potential markers of seroconversion in treated chagasic patients. Prospective study, involving 203 patients treated with benznidazole, w
Externí odkaz:
https://doaj.org/article/a838bcfe13b84d6d88d581bcde83470a
Autor:
Silvia A. Longhi, Lady J. García Casares, Arturo A. Muñoz-Calderón, Julio Alonso-Padilla, Alejandro G. Schijman
Publikováno v:
PLOS Neglected Tropical Diseases. 17:e0011290
Background Chagas disease or American trypanosomiasis, a neglected tropical disease, is a persistent Public Health problem in Latin America and other, non-endemic, countries. Point-of-care (POC) sensitive methods are still needed to improve and exten
Autor:
Natalia Anahí Juiz, María Elisa Solana, Gonzalo Raúl Acevedo, Alejandro Francisco Benatar, Juan Carlos Ramirez, Priscilla Almeida da Costa, Andrea Mara Macedo, Silvia Andrea Longhi, Alejandro G Schijman
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 3, p e0005436 (2017)
Congenital infection of Trypanosoma cruzi allows transmission of this parasite through generations. Despite the problematic that this entails, little is known about the placenta environment genetic response produced against infection. We performed fu
Externí odkaz:
https://doaj.org/article/93006ca35c8541dfbedcfb78bd366b53
Autor:
Gonzalo R Acevedo, Silvia A Longhi, Alcinette Bunying, Nazila Sabri, Augusto Atienza, María P Zago, Radleigh Santos, Valeria A Judkowski, Clemencia Pinilla, Karina A Gómez
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178380 (2017)
The discovery of T cell epitopes is essential not only for gaining knowledge about host response to infectious disease but also for the development of immune-intervention strategies. In Chagas disease, given the size and complexity of the Trypanosoma
Externí odkaz:
https://doaj.org/article/f53fbb7702f2495888a7a9a4b9e299b2