Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Silvia A Purro"'
Autor:
Silvia A Purro, Michael Farmer, Elizabeth Noble, Claire J Sarell, Megan Powell, Daniel Yip, Lauren Giggins, Leila Zakka, David X Thomas, Mark Farrow, Andrew J Nicoll, Dominic Walsh, John Collinge
Publikováno v:
PLoS ONE, Vol 18, Iss 11, p e0294465 (2023)
Oligomers formed from monomers of the amyloid β-protein (Aβ) are thought to be central to the pathogenesis of Alzheimer's disease (AD). Unsurprisingly for a complex disease, current mouse models of AD fail to fully mimic the clinical disease in hum
Externí odkaz:
https://doaj.org/article/8af80f9aedd94ca28f2439779fee4821
Autor:
Silvia A. Purro, Michael Farmer, Elizabeth Noble, Claire J. Sarell, Megan Powell, Daniel Chun-Mun Yip, Lauren Giggins, Leila Zakka, David X. Thomas, Mark A. Farrow, Andrew J. Nicoll, Dominic Walsh, John Collinge
The aggregation of amyloid-β (Aβ) monomers increases their neurotoxicity, and these oligomeric species are thought to be central to the pathogenesis of Alzheimer’s disease. Unsurprisingly for such a complex disease, current Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7b5c337a832f741bf56d086ace8316cc
https://doi.org/10.1101/2022.09.25.508690
https://doi.org/10.1101/2022.09.25.508690
Publikováno v:
Biological Psychiatry. 83:358-368
The initial report that cellular prion protein (PrPC) mediates toxicity of amyloid-β species linked to Alzheimer's disease was initially treated with scepticism, but growing evidence supports this claim. That there is a high-affinity interaction is
Autor:
Tamsin Nazari, Zhicheng Chen, John Collinge, Peter Rudge, M Farrow, Sebastian Brandner, Silvia A. Purro, David Mengel, Takashi Saito, Jacqueline M. Linehan, David X. Thomas, Takaomi C. Saido, Dominic M. Walsh
Publikováno v:
Nature. 564(7736)
We previously reported(1) the presence of amyloid-β protein (Aβ) deposits in individuals with Creutzfeldt–Jakob disease (CJD) who had been treated during childhood with human cadaveric pituitary-derived growth hormone (c-hGH) contaminated with pr
Publikováno v:
Biological psychiatry. 84(7)
Autor:
Carlos A. Arce, Guillermo G. Zampar, Silvia A. Purro, C. Gastón Bisig, Verónica S. Santander, María E. Chesta
Publikováno v:
FEBS Journal. 276:7110-7123
In many laboratories, the requirement of microtubule-associated proteins (MAPs) and the stabilization of microtubules for the elongation of neurites has been intensively investigated, with controversial results being obtained. We have observed that t
Autor:
Monica Hoyos-Flight, Eliza Siomou, Patricia C. Salinas, Lorenza Ciani, Silvia A. Purro, Eleanna Stamatakou
Publikováno v:
The Journal of Neuroscience. 28:8644-8654
Axon guidance and target-derived signals control axonal behavior by regulating the cytoskeleton through poorly defined mechanisms. In particular, how these signaling molecules regulate the growth and directionality of microtubules is not well underst
Publikováno v:
European Journal of Biochemistry. 270:4921-4929
The association of tubulin carboxypeptidase with microtubules may be involved in the determination of the tyrosination state of the microtubules, i.e. their proportion of tyrosinated vs. nontyrosinated tubulin. We investigated the role of protein pho
Publikováno v:
European Journal of Biochemistry. 269:5037-5045
The C-terminus of the alpha-chain of tubulin is subject to reversible incorporation of tyrosine by tubulin tyrosine ligase and removal by tubulin carboxypeptidase. Thus, microtubules rich in either tyrosinated or detyrosinated tubulin can coexist in
Publikováno v:
Journal of Neuroscience
Extensive evidence supports a central role for amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease (AD). Synaptic loss mediated by Aβ in early stages of the disease might contribute to cognitive impairments. However, little is known about th