Výsledky vyhledávání - "Silvia Scaramuzza"

Akademický článek

Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

Autor: Fabio Selis, Giuseppina Focà, Annamaria Sandomenico, Carla Marra, Concetta Di Mauro, Gloria Saccani Jotti, Silvia Scaramuzza, Annalisa Politano, Riccardo Sanna, Menotti Ruvo, Giancarlo Tonon

Publikováno v: International Journal of Molecular Sciences, Vol 17, Iss 4, p 491 (2016)

PEGylation of biomolecules is a major approach to increase blood stream half-life, stability and solubility of biotherapeutics and to reduce their immunogenicity, aggregation potential and unspecific interactions with other proteins and tissues. Anti

Externí odkaz: https://doaj.org/article/f189fefc402a43d2ba991e82624c3cf3

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Generation and testing of engineered multimeric Fabs of trastuzumab

Autor: Annamaria Sandomenico, Silvia Scaramuzza, Fabio Selis, Emanuela Iaccarino, Luisa Calvanese, Andrea Esperti, Emanuela Truppo, Paolo Dell'Omo, Maria Cantile, Sandro De Falco, Lucia Falcigno, Menotti Ruvo, Andrea Caporale, Riccardo Sanna, Giancarlo Tonon, Annalia Focà

Publikováno v: International journal of biological macromolecules 164 (2020): 4516–4531. doi:10.1016/j.ijbiomac.2020.09.050
info:cnr-pdr/source/autori:Selis F.; Sandomenico A.; Cantile M.; Sanna R.; Calvanese L.; Falcigno L.; Dell'Omo P.; Esperti A.; De Falco S.; Foca A.; Caporale A.; Iaccarino E.; Truppo E.; Scaramuzza S.; Tonon G.; Ruvo M./titolo:Generation and testing of engineered multimeric Fabs of trastuzumab/doi:10.1016%2Fj.ijbiomac.2020.09.050/rivista:International journal of biological macromolecules/anno:2020/pagina_da:4516/pagina_a:4531/intervallo_pagine:4516–4531/volume:164

Recombinant antibodies fragments in several new formats are routinely investigated and used in diagnostic and therapeutic applications as anti-cancers molecules. New antibody formats are generated to compensate the need for multispecificity and site-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c83f8eb5924b3f47cced55512ce8ab
http://hdl.handle.net/11588/825466

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Akademický článek

Biophysical characterization of Met-G-CSF: effects of different site-specific mono-pegylations on protein stability and aggregation.

Autor: Antonino Natalello, Diletta Ami, Maddalena Collini, Laura D'Alfonso, Giuseppe Chirico, Giancarlo Tonon, Silvia Scaramuzza, Rodolfo Schrepfer, Silvia Maria Doglia

Publikováno v: PLoS ONE, Vol 7, Iss 8, p e42511 (2012)

The limited stability of proteins in vitro and in vivo reduces their conversion into effective biopharmaceuticals. To overcome this problem several strategies can be exploited, as the conjugation of the protein of interest with polyethylene glycol, i

Externí odkaz: https://doaj.org/article/404bbb28e53f41898cecc5909c62caeb

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Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen

Autor: Giancarlo Tonon, Annamaria Sandomenico, Giuseppina Focà, Gloria Saccani Jotti, Silvia Scaramuzza, Fabio Selis, Concetta Di Mauro, Menotti Ruvo, Riccardo Sanna, Carla Marra, Annalisa Politano

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 17; Issue 4; Pages: 491
International Journal of Molecular Sciences, Vol 17, Iss 4, p 491 (2016)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1317bb2ef884f661f8ec0f37a46e999
https://pubmed.ncbi.nlm.nih.gov/27043557

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PEG-epirubicin Conjugates with High Drug Loading

Autor: Oddone Schiavon, Francesco M. Veronese, Roberto Mendichi, Gianfranco Pasut, Silvia Scaramuzza

Publikováno v: Journal of Bioactive and Compatible Polymers. 20:213-230

PEG is used as a polymeric carrier for low molecular weight drugs, but limitations arise from the fact that only one or two hydroxyl residues are on each polymer. Therefore, the synthesis of dendrimeric structures, based on amino adipic acid or beta-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85e2c3259d57d8474a1dea3ef485a7ad
https://doi.org/10.1177/0883911505053377

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Enzymatic mono-pegylation of glucagon-like peptide 1 towards long lasting treatment of type 2 diabetes

Autor: Silvia Scaramuzza, Pierluigi Onali, Fabio Selis, Stefano Genovese, Rodolfo Schrepfer, Simona Dedoni, Gaetano Orsini, Giancarlo Tonon, Riccardo Sanna

Publikováno v: Results in Pharma Sciences

Human glucagon-like peptide-1 (GLP-1) is a physiological gastrointestinal peptide with glucose-dependent insulinotropic effects which is therefore considered an interesting antidiabetic agent. However, after in vivo administration, exogenous GLP-1 do

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e645b21a72b7cf12432542776020598c
https://pubmed.ncbi.nlm.nih.gov/25755995

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A new site-specific monoPEGylated filgrastim derivative prepared by enzymatic conjugation: Production and physicochemical characterization

Autor: Paolo Caliceti, Giancarlo Tonon, Rodolfo Schrepfer, Irene Messana, Alessandra Olianas, Silvia Scaramuzza, Gaetano Orsini

We describe the preparation and characterization of a new monoPEGylated derivate of a recombinant form of filgrastim (methionyl human granulocite colony stimulating factor, rh-Met-G-CSF), BK0026, prepared by enzymatic site-specific 20kDa PEG conjugat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e138a5e556cf801708964a5838d837b9
http://hdl.handle.net/11577/2506501

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A new PEG-beta-alanine active derivative for releasable protein conjugation

Autor: Francesco M. Veronese, Luigi Sollai, Anna Mero, Silvia Scaramuzza, Gianfranco Pasut, Francesca Caboi

Publikováno v: Bioconjugate chemistry. 19(12)

A new PEGylating agent, PEG-betaAla-NHCO-OSu, has been studied for protein amino conjugation using human growth hormone (hGH) and granulocyte colony stimulating factor (G-CSF) as model therapeutic proteins. This new activated PEG possesses a convenie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22213ed9b2fb83be7bfbebd611377d0c
https://pubmed.ncbi.nlm.nih.gov/19053302

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Akademický článek

A New PEG−β-Alanine Active Derivative for Releasable Protein Conjugation.

Autor: Gianfranco Pasut, Anna Mero, Francesca Caboi, Silvia Scaramuzza, Luigi Sollai, Francesco M. Veronese

Publikováno v: Bioconjugate Chemistry; Dec2008, Vol. 19 Issue 12, p2427-2431, 5p

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