Zobrazeno 1 - 10
of 273
pro vyhledávání: '"Silvia, Schenone"'
Autor:
Ilaria Giacchello, Annarita Cianciusi, Chiara Bertagnin, Anna Bonomini, Valeria Francesconi, Mattia Mori, Anna Carbone, Francesca Musumeci, Arianna Loregian, Silvia Schenone
Publikováno v:
Pharmaceutics, Vol 16, Iss 7, p 954 (2024)
The limited range of available flu treatments due to virus mutations and drug resistance have prompted the search for new therapies. RNA-dependent RNA polymerase (RdRp) is a heterotrimeric complex of three subunits, i.e., polymerase acidic protein (P
Externí odkaz:
https://doaj.org/article/c6335ef946f64501a6e9753dc49c8aac
Autor:
Alexandra Hochstetler, Hillary Smith, Makenna Reed, Louise Hulme, Paul Territo, Amanda Bedwell, Scott Persohn, Nicola Perrotti, Lucia D’Antona, Francesca Musumeci, Silvia Schenone, Bonnie L. Blazer-Yost
Publikováno v:
Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-14 (2023)
Abstract Background Hydrocephalus is a pathological accumulation of cerebrospinal fluid (CSF), leading to ventriculomegaly. Hydrocephalus may be primary or secondary to traumatic brain injury, infection, or intracranial hemorrhage. Regardless of caus
Externí odkaz:
https://doaj.org/article/8074d949e52d428b89b2452191283773
Autor:
Naomi Scarano, Chiara Brullo, Francesca Musumeci, Enrico Millo, Santina Bruzzone, Silvia Schenone, Elena Cichero
Publikováno v:
Pharmaceuticals, Vol 17, Iss 5, p 601 (2024)
Sirtuins (SIRTs) are classified as class III histone deacetylases (HDACs), a family of enzymes that catalyze the removal of acetyl groups from the ε-N-acetyl lysine residues of histone proteins, thus counteracting the activity performed by histone a
Externí odkaz:
https://doaj.org/article/d5906f7cafd5488090cdfc20c7c9686f
Unlocking Potential and Limits of Kinase Inhibitors: The Highway to Enhanced Cancer Targeted Therapy
Autor:
Francesca Musumeci, Silvia Schenone
Publikováno v:
Pharmaceutics, Vol 16, Iss 5, p 625 (2024)
Kinases are a family of enzymes comprising over five hundred members, which, when overexpressed or hyperactivated, are implicated in the pathogenesis of numerous hematological and solid cancers [...]
Externí odkaz:
https://doaj.org/article/d4664b2e78284a84bc95acb3318a4197
Autor:
Giancarlo Grossi, Naomi Scarano, Francesca Musumeci, Michele Tonelli, Evgeny Kanov, Anna Carbone, Paola Fossa, Raul R. Gainetdinov, Elena Cichero, Silvia Schenone
Publikováno v:
Molecules, Vol 29, Iss 8, p 1739 (2024)
The search for novel effective TAAR1 ligands continues to draw great attention due to the wide range of pharmacological applications related to TAAR1 targeting. Herein, molecular docking studies of known TAAR1 ligands, characterized by an oxazoline c
Externí odkaz:
https://doaj.org/article/c00b5f6dfd8e4b0f9d0943f5ad4f6b79
Autor:
Davide Frumento, Giancarlo Grossi, Marta Falesiedi, Francesca Musumeci, Anna Carbone, Silvia Schenone
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1398 (2024)
In the last decade, many small molecules, usually characterized by heterocyclic scaffolds, have been designed and synthesized as tyrosine kinase inhibitors (TKIs). Among them, several compounds have been tested at preclinical and clinical levels to t
Externí odkaz:
https://doaj.org/article/cc6fe6714420403ebb947a70f7931c3e
Autor:
Naomi Scarano, Francesco Di Palma, Nicola Origlia, Francesca Musumeci, Silvia Schenone, Sonia Spinelli, Mario Passalacqua, Elena Zocchi, Laura Sturla, Elena Cichero, Andrea Cavalli
Publikováno v:
Pharmaceutics, Vol 15, Iss 12, p 2754 (2023)
The lanthionine synthetase C-like (LANCL) proteins include LANCL2, which is expressed in the central nervous system (CNS) and in peripheral tissues. LANCL2 exhibits glutathionylation activity and is involved in the neutralization of reactive electrop
Externí odkaz:
https://doaj.org/article/abc95c220691413f81e9bfd0dbc7cf75
Autor:
Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Anna Carbone, Francesca Musumeci, Silvia Schenone, Elena Dreassi
Publikováno v:
Pharmaceuticals, Vol 16, Iss 11, p 1527 (2023)
Although patients would rather oral therapies to injections, the gastrointestinal tract’s low permeability makes this method limiting for most compounds, including anticancer drugs. Due to their low bioavailability, oral antitumor therapies suffer
Externí odkaz:
https://doaj.org/article/0c24052588a24c2d985bde16104856df
Autor:
Federica Barbieri, Alessia Graziana Bosio, Alessandra Pattarozzi, Michele Tonelli, Adriana Bajetto, Ivan Verduci, Francesca Cianci, Gaetano Cannavale, Luca M. G. Palloni, Valeria Francesconi, Stefano Thellung, Pietro Fiaschi, Samanta Mazzetti, Silvia Schenone, Beatrice Balboni, Stefania Girotto, Paolo Malatesta, Antonio Daga, Gianluigi Zona, Michele Mazzanti, Tullio Florio
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-27 (2022)
Abstract Background Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in
Externí odkaz:
https://doaj.org/article/7b56612354df4a31ad989eb52608dd88
Autor:
Claudia Contadini, Claudia Cirotti, Anna Carbone, Mehrdad Norouzi, Annarita Cianciusi, Emmanuele Crespan, Cecilia Perini, Giovanni Maga, Daniela Barilà, Francesca Musumeci, Silvia Schenone
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 958 (2023)
Src is a non-receptor tyrosine kinase (TK) whose involvement in cancer, including glioblastoma (GBM), has been extensively demonstrated. In this context, we started from our in-house library of pyrazolo[3,4-d]pyrimidines that are active as Src and/or
Externí odkaz:
https://doaj.org/article/cb6c5b3f3a3c4429a456fa6d37613bc6