Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Silvia, Paoletta"'
Autor:
Johann S. de Bono, Neil Pegg, Karen E. Knudsen, Matthew J. Schiewer, David Taddei, Amanda Swain, Jian Ning, Antje J. Neeb, Suzanne Carreira, Nina Tunariu, Rita Pereira, Ana Ferreira, Mateus Crespo, Susana Miranda, Veronica S. Gil, Gareth W. Harbottle, Don Smyth, Richard Brown, Silvia Paoletta, Jonathan Shannon, Stuart Onions, Jenny Worthington, Stuart Thomson, Jordan Lane, Amy Prosser, Meera Raja, Barbara Young, William West, Denisa Bogdan, Jan Rekowski, Bora Gurel, Ruth Riisnaes, Ines Figueiredo, Abhijit Pal, Saswati N. Chand, Christopher McNair, Wei Yuan, Nigel Brooks, Adam Sharp, Jonathan Welti
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of AR (AR-SV). Inhibitors of transcriptional coactivators that regulate AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c73d8a93c6f4a3feb2612ceef314ced
https://doi.org/10.1158/2159-8290.c.6549379
https://doi.org/10.1158/2159-8290.c.6549379
Autor:
Johann S. de Bono, Neil Pegg, Karen E. Knudsen, Matthew J. Schiewer, David Taddei, Amanda Swain, Jian Ning, Antje J. Neeb, Suzanne Carreira, Nina Tunariu, Rita Pereira, Ana Ferreira, Mateus Crespo, Susana Miranda, Veronica S. Gil, Gareth W. Harbottle, Don Smyth, Richard Brown, Silvia Paoletta, Jonathan Shannon, Stuart Onions, Jenny Worthington, Stuart Thomson, Jordan Lane, Amy Prosser, Meera Raja, Barbara Young, William West, Denisa Bogdan, Jan Rekowski, Bora Gurel, Ruth Riisnaes, Ines Figueiredo, Abhijit Pal, Saswati N. Chand, Christopher McNair, Wei Yuan, Nigel Brooks, Adam Sharp, Jonathan Welti
Supplementary figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d313da933b889d09a6fcaf5a2385ff7
https://doi.org/10.1158/2159-8290.22540441.v1
https://doi.org/10.1158/2159-8290.22540441.v1
Autor:
Kenneth A. Jacobson, Zhan-Guo Gao, Silvia Paoletta, Evgeny Kiselev, Saibal Chakraborty, P. Suresh Jayasekara, Ramachandran Balasubramanian, Dilip K. Tosh
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 13, Iss C, Pp 286-298 (2015)
We establish structure activity relationships of extracellular nucleosides and nucleotides at G protein-coupled receptors (GPCRs), e.g. adenosine receptors (ARs) and P2Y receptors (P2YRs), respectively. We synthesize selective agents for use as pharm
Externí odkaz:
https://doaj.org/article/686be93f45ac4dfb968a2fbc6eac9d91
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97858 (2014)
We studied patterns of off-target receptor interactions, mostly at G protein-coupled receptors (GPCRs) in the µM range, of nucleoside derivatives that are highly engineered for nM interaction with adenosine receptors (ARs). Because of the considerab
Externí odkaz:
https://doaj.org/article/ace86eab7e5a4a2ab2880a981aa17038
Autor:
Matthew J. Schiewer, Susana Miranda, William West, Suzanne Carreira, Stuart Thomson, Gareth W. Harbottle, Ana Ferreira, Stuart Thomas Onions, Donald Smyth, Nigel Brooks, Jonathan Shannon, Jonathan Welti, Nina Tunariu, Johann S. de Bono, Christopher McNair, Jenny Worthington, Wei Yuan, Karen E. Knudsen, Adam Sharp, Barbara Young, Amy Prosser, Jan Rekowski, Su C, Rita Pereira, Amanda Swain, Jian Ning, Abhijit Pal, Jordan Lane, Ruth Riisnaes, Bora Gurel, Ines Figueiredo, Mateus Crespo, Richard J. C. Brown, Saswati N. Chand, David Michel Adrien Taddei, Denisa Bogdan, Veronica Gil, Silvia Paoletta, Meera Raja, Neil Anthony Pegg, Antje Neeb
Publikováno v:
Cancer discovery. 11(5)
Resistance to androgen receptor (AR) blockade in castration-resistant prostate cancer (CRPC) is associated with sustained AR signaling, including through alternative splicing of AR (AR-SV). Inhibitors of transcriptional coactivators that regulate AR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbe14e20a3d6b9fa6c1304e667e02ff
https://pubmed.ncbi.nlm.nih.gov/33947717
https://pubmed.ncbi.nlm.nih.gov/33947717
Autor:
Tina C. Wan, Kenneth A. Jacobson, Lili Du, Zhan Guo Gao, Silvia Paoletta, Elizabeth T. Gizewski, Adriaan P. IJzerman, John A. Auchampach, Jacobus P. D. van Veldhoven, Samantha Barbour
Publikováno v:
Purinergic Signalling. 14:59-71
Activity of the A(3) adenosine receptor (AR) allosteric modulators LUF6000 (2-cyclohexyl-N-(3,4-dichlorophenyl)-1H-imidazo [4,5-c]quinolin-4-amine) and LUF6096 (N-{2-[(3,4-dichlorophenyl)amino]quinolin-4-yl}cyclohexanecarbox-amide) was compared at fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5509f6a3ecaa7b8820a71c7b34513f4
https://doi.org/10.1007/s11302-017-9592-1
https://doi.org/10.1007/s11302-017-9592-1
Autor:
Sonja Kachler, Stefano Moro, Karl-Norbert Klotz, Kenneth A. Jacobson, Giampiero Spalluto, Giorgia Pastorin, Stephanie Federico, Silvia Paoletta, Enrico Margiotta
A series of adenosine receptor antagonists bearing a reactive linker was developed. Functionalization of these derivatives is useful to easily obtain multi-target ligands, receptor probes, drug delivery systems, and diagnostic or theranostic systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6f942729e5c76c897b6059b172c5215
https://europepmc.org/articles/PMC6644567/
https://europepmc.org/articles/PMC6644567/
Autor:
Barbara Zieger, Eti Alessandra Femia, Christian Gachet, Marco Cattaneo, Gian Marco Podda, Philippe Ohlmann, Silvia Paoletta, Anna Lecchi, Arnaud Dupuis, Katharina Machura, Kenneth A. Jacobson
Publikováno v:
Hämostaseologie. 36:279-283
SummaryThe platelet adenosine 5’-diphosphate (ADP) receptor P2Y12 (P2Y12R) plays a critical role in platelet aggregation. The present report illustrates an update of dysfunctional platelet P2Y12R mutations diagnosed with congenital lifelong bleedin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08c80ff624acd04311c3f09b541b54f0
https://doi.org/10.5482/hamo-16-03-0010
https://doi.org/10.5482/hamo-16-03-0010
Publikováno v:
Bioorganic & Medicinal Chemistry. 23:4056-4064
The P2Y14 receptor (P2Y14R) is a Gi protein-coupled receptor that is activated by uracil nucleotides UDP and UDP-glucose. The P2Y14R structure has yet to be solved through X-ray crystallography, but the recent agonist-bound crystal structure of the P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf3272e47fa66ac7491579beb12c545
https://doi.org/10.1016/j.bmc.2015.03.042
https://doi.org/10.1016/j.bmc.2015.03.042
Autor:
Zhoumou Chen, Kenneth A. Jacobson, Elizabeth T. Gizewski, Steven Crane, Silvia Paoletta, Daniela Salvemini, Zhan-Guo Gao, John A. Auchampach, Dilip K. Tosh
Publikováno v:
ACS Medicinal Chemistry Letters. 6:804-808
Substitution of rigidified A3 adenosine receptor (AR) agonists with a 2-((5-chlorothiophen-2-yl)ethynyl) or a 2-(4-(5-chlorothiophen-2-yl)-1H-1,2,3-triazol-1-yl) group provides prolonged protection in a model of chronic neuropathic pain. These agonis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76a9d751b975da202dbdc38408a2c54
https://doi.org/10.1021/acsmedchemlett.5b00150
https://doi.org/10.1021/acsmedchemlett.5b00150