Zobrazeno 1 - 10
of 83
pro vyhledávání: '"Silvia, Nistri"'
Publikováno v:
Antioxidants, Vol 13, Iss 2, p 163 (2024)
Serelaxin (RLX), namely the human recombinant Relaxin-2 hormone, protects the heart from ischemia/reperfusion (I/R)-induced damage due to its anti-inflammatory, anti-apoptotic and antioxidant properties. RLX acts by binding to its specific RXFP1 rece
Externí odkaz:
https://doaj.org/article/7162bfdd265e4fffa0b0aee94627d5e7
Autor:
Annunziata D'Ercole, Silvia Nistri, Lorenzo Pacini, Alfonso Carotenuto, Federica Santoro, Anna Maria Papini, Ross A. D. Bathgate, Daniele Bani, Paolo Rovero
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The peptide hormone relaxin (RLX), also available as clinical-grade recombinant protein (serelaxin), holds great promise as a cardiovascular and anti-fibrotic agent but is limited by the pharmacokinetic issues common to all peptide drugs. In this stu
Externí odkaz:
https://doaj.org/article/df68676b7ec8426f970ad17c8d091f2b
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Resistin, among its several actions, has been reported to exert central anorexigenic effects in rodents. Some adipokines which centrally modulate food intake have also been reported to affect the activity of gastric smooth muscle, whose motor respons
Externí odkaz:
https://doaj.org/article/077049bfc3cc4b24a52074f9f1b5b7b5
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Cigarette smoking (CS) is the cause of several organ and apparatus diseases. The effects of smoke in the gut are partially known. Accumulating evidence has shown a relationship between smoking and inflammatory bowel disease, prompting us to investiga
Externí odkaz:
https://doaj.org/article/6a459dfdf1264acabe0c725ea93990fc
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 24, p 16113 (2022)
It has been reported that adiponectin (ADPN) and resistin are co-secreted by white mouse adipocytes and exert similar inhibitory effects in the mouse gastric fundus, in which resistin was observed to increase neuronal nitric oxide synthase (nNOS) exp
Externí odkaz:
https://doaj.org/article/b8a52761a607451da77bd241da5b1322
Autor:
Lorenzo Pacini, Annunziata D’Ercole, Anna Maria Papini, Daniele Bani, Silvia Nistri, Paolo Rovero
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 1, p 48 (2022)
Despite human recombinant H2 relaxin or serelaxin holding promise as a cardiovascular drug, its actual efficacy in chronic treatment of heart failure patients was hampered by the need to be administered by multiple daily IV injections for a long time
Externí odkaz:
https://doaj.org/article/1fbd620fd89b46daae809fe644f11096
Autor:
Matteo Becatti, Andrea Bencini, Silvia Nistri, Luca Conti, Maria Giulia Fabbrini, Laura Lucarini, Veronica Ghini, Mirko Severi, Claudia Fiorillo, Claudia Giorgi, Lorenzo Sorace, Barbara Valtancoli, Daniele Bani
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-20 (2019)
Abstract Oxidative stress due to excess superoxide anion ($${{\bf{O}}}_{{\bf{2}}}^{{\boldsymbol{\cdot }}{\boldsymbol{-}}}$$ O2⋅− ) produced by dysfunctional mitochondria is a key pathogenic event of aging and ischemia-reperfusion diseases. Here,
Externí odkaz:
https://doaj.org/article/04182cdca23f47ec9e1ab153252d5613
Autor:
Eglantina Idrizaj, Rachele Garella, Silvia Nistri, Alfonso Dell’Accio, Emanuele Cassioli, Eleonora Rossi, Giovanni Castellini, Valdo Ricca, Roberta Squecco, Maria Caterina Baccari
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9617 (2020)
Some adipokines, such as adiponectin (ADPN), other than being implicated in the central regulation of feeding behavior, may influence gastric motor responses, which are a source of peripheral signals that also influence food intake. The present study
Externí odkaz:
https://doaj.org/article/973b3be40027420a895024a7016d41f7
Publikováno v:
Antioxidants, Vol 9, Iss 9, p 774 (2020)
Serelaxin (RLX) designates the pharmaceutical form of the human natural hormone relaxin-2 that has been shown to markedly reduce tissue and cell damage induced by hypoxia and reoxygenation (HR). The evidence that RLX exerts similar protective effects
Externí odkaz:
https://doaj.org/article/2d33a65802af46aca6a54cc843218417
Autor:
Silvia Nistri, Lorenzo Di Cesare Mannelli, Carla Ghelardini, Matteo Zanardelli, Daniele Bani, Paola Failli
Publikováno v:
Molecules, Vol 20, Iss 6, Pp 9524-9535 (2015)
We demonstrated that in coronary endothelial cells (RCEs) from normotensive Wistar Kyoto rats (WKY), the hormone relaxin (RLX) increases NO production and reduces calcium transients by a NO-related mechanism. Since an impairment of the NO pathway has
Externí odkaz:
https://doaj.org/article/8a83e435af364fe88b643754d0650533