Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Silvia, Muro"'
Autor:
Maria del Moral, Maximilian Loeck, Eameema Muntimadugu, Guillem Vives, Vy Pham, Peter Pfeifer, Giuseppe Battaglia, Silvia Muro
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 9, p 440 (2023)
Prior studies demonstrated that encapsulation in poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) enhanced the delivery of enzymes used for replacement therapy (ERT) of lysosomal storage disorders (LSDs). This study examined how the copolymer
Externí odkaz:
https://doaj.org/article/cdebf2306601418baf97f97b042f81a0
Autor:
Yingwei Chen, Eric A. Toth, Biao Ruan, Eun Jung Choi, Richard Simmerman, Yihong Chen, Yanan He, Ruixue Wang, Raquel Godoy-Ruiz, Harlan King, Gregory Custer, D. Travis Gallagher, David A. Rozak, Melani Solomon, Silvia Muro, David J. Weber, John Orban, Thomas R. Fuerst, Philip N. Bryan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Chen et al. describe a rational design of subtilisin mutants that degrade active RAS by cleaving a conserved sequence in switch 2. They further modified the active site to be dependent on a cofactor to generate high target specificity. Proteases engi
Externí odkaz:
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1496 (2022)
3DNA holds promise as a carrier for drugs that can be intercalated into its core or linked to surface arms. Coupling 3DNA to an antibody targeting intercellular adhesion molecule 1 (ICAM-1) results in high lung-specific biodistributions in vivo. Whil
Externí odkaz:
https://doaj.org/article/dfc3a178d5a844d2847032fecb93661d
Publikováno v:
Bioengineering & Translational Medicine, Vol 6, Iss 2, Pp n/a-n/a (2021)
Abstract Biodistribution studies are essential in drug carrier design and translation, and radiotracing provides a sensitive quantitation for this purpose. Yet, for biodegradable formulations, small amounts of free‐label signal may arise prior to o
Externí odkaz:
https://doaj.org/article/2a4a4d1b2a5648f9b3b88cead5a879eb
Autor:
Eameema Muntimadugu, Marcelle Silva-Abreu, Guillem Vives, Maximilian Loeck, Vy Pham, Maria del Moral, Melani Solomon, Silvia Muro
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 4034 (2022)
Poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs) enhance the delivery of therapeutic enzymes for replacement therapy of lysosomal storage disorders. Previous studies examined NPs encapsulating or coated with enzymes, but these formulations have
Externí odkaz:
https://doaj.org/article/bb235b0f0db64fd691290b19b81858e6
Autor:
Bareera Qamar, Melani Solomon, Alexander Marin, Thomas R. Fuerst, Alexander K. Andrianov, Silvia Muro
Publikováno v:
Pharmaceutics, Vol 13, Iss 2, p 249 (2021)
Achieving intracellular delivery of protein therapeutics within cells remains a significant challenge. Although custom formulations are available for some protein therapeutics, the development of non-toxic delivery systems that can incorporate a vari
Externí odkaz:
https://doaj.org/article/a647b9cadc994d55bfcf9c3e6fc770c3
Autor:
John Orban, Yihong Chen, Yanan He, David J. Weber, Eun Jung Choi, Raquel Godoy-Ruiz, Biao Ruan, D. Travis Gallagher, Melani Solomon, Thomas R. Fuerst, Ruixue Wang, David A. Rozak, Gregory S. Custer, Philip N. Bryan, Harlan King, Silvia Muro, Eric A. Toth, Yingwei Chen, Richard Simmerman
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
Communications Biology
Communications Biology
We describe the design, kinetic properties, and structures of engineered subtilisin proteases that degrade the active form of RAS by cleaving a conserved sequence in switch 2. RAS is a signaling protein that, when mutated, drives a third of human can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::768ae163ddb6ebc0c904ea01793832d2
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
https://doaj.org/article/742c1a3e0584400b8b631c6e4a1b0ff6
Autor:
Patrick M. Glassman, Jia Nong, Jacob W. Myerson, Viviana Zuluaga-Ramirez, Alba Rodriguez-Garcia, Alvin Mukalel, Serena Omo-Lamai, Landis R. Walsh, Raisa Y. Kiseleva, Carlos H. Villa, Colin F. Greineder, Scott E. Kasner, Drew Weissman, Michael J. Mitchell, Silvia Muro, Yuri Persidsky, Jacob S. Brenner, Vladimir R. Muzykantov, Oscar A. Marcos-Contreras
Selective drug delivery to injured regions of the brain is an elusive, but biomedically important, goal. It is tempting to co-opt migrating white blood cells (WBC) to carry drugs to the injured brain, using natural WBC tropism. Current approaches to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e39c3ed6e4a869dbbf373a4fc6078f6
https://doi.org/10.1101/2022.02.04.479150
https://doi.org/10.1101/2022.02.04.479150
Autor:
Melani Solomon, Maximilian Loeck, Marcelle Silva-Abreu, Ronaldo Moscoso, Ronelle Bautista, Marco Vigo, Silvia Muro
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 349
Treatment of neurological lysosomal storage disorders (LSDs) are limited because of impermeability of the blood-brain barrier (BBB) to macromolecules. Nanoformulations targeting BBB transcytosis are being explored, but the status of these routes in L
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2edc09dd5113d51e7f62c4973ca2b2d
https://pubmed.ncbi.nlm.nih.gov/35901858
https://pubmed.ncbi.nlm.nih.gov/35901858
Autor:
Silvia Muro
Publikováno v:
Biomimetics, Vol 3, Iss 3, p 19 (2018)
Endocytosis and vesicular trafficking are cellular processes that regulate numerous functions required to sustain life. From a translational perspective, they offer avenues to improve the access of therapeutic drugs across cellular barriers that sepa
Externí odkaz:
https://doaj.org/article/82ad7c2f8f32408d9ec340629c121904