Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Silvia, Middei"'
Autor:
Marzia Indrigo, Ilaria Morella, Daniel Orellana, Raffaele d'Isa, Alessandro Papale, Riccardo Parra, Antonia Gurgone, Daniela Lecca, Anna Cavaccini, Cezar M Tigaret, Alfredo Cagnotto, Kimberley Jones, Simon Brooks, Gian Michele Ratto, Nicholas D Allen, Mariah J Lelos, Silvia Middei, Maurizio Giustetto, Anna R Carta, Raffaella Tonini, Mario Salmona, Jeremy Hall, Kerrie Thomas, Riccardo Brambilla, Stefania Fasano
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp 1-25 (2023)
Abstract Cell signaling is central to neuronal activity and its dysregulation may lead to neurodegeneration and cognitive decline. Here, we show that selective genetic potentiation of neuronal ERK signaling prevents cell death in vitro and in vivo in
Externí odkaz:
https://doaj.org/article/07ec956f4df240a18ad3746f40460254
Autor:
Emanuela Rizzello, Domenico Pimpinella, Annabella Pignataro, Giulia Titta, Elisabetta Merenda, Michela Saviana, Giovanni Francesco Porcheddu, Chiara Paolantoni, Francesca Malerba, Corinna Giorgi, Giulia Curia, Silvia Middei, Cristina Marchetti
Publikováno v:
Neurobiology of Disease, Vol 181, Iss , Pp 106106- (2023)
Epilepsy is a comorbidity associated with Alzheimer's disease (AD), often starting many years earlier than memory decline. Investigating this association in the early pre-symptomatic stages of AD can unveil new mechanisms of the pathology as well as
Externí odkaz:
https://doaj.org/article/59eee80ed5da48d7a674b8cffa2e0e3c
Publikováno v:
Neural Plasticity, Vol 2022 (2022)
The mammalian hippocampal dentate gyrus is a niche for adult neurogenesis from neural stem cells. Newborn neurons integrate into existing neuronal networks, where they play a key role in hippocampal functions, including learning and memory. In the ag
Externí odkaz:
https://doaj.org/article/6d582d99d3ab4d9185583f393d8a3692
Autor:
Sylvia Badurek, Marilena Griguoli, Aman Asif-Malik, Barbara Zonta, Fei Guo, Silvia Middei, Laura Lagostena, Maria Teresa Jurado-Parras, Thomas H. Gillingwater, Agnès Gruart, José María Delgado-García, Enrico Cherubini, Liliana Minichiello
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Early in brain development, impaired neuronal signaling during time-sensitive windows triggers the onset of neurodevelopmental disorders. GABA, through its depolarizing and excitatory actions, drives early developmental events including neur
Externí odkaz:
https://doaj.org/article/2880f8a3122b4856a0cc9a58b1dfea98
Autor:
Silvia Middei, Ludovica Giorgini, Valentina Vacca, Francesca Storri, Sabrina Putti, Georgios Strimpakos, Marcello Raspa, Ferdinando Scavizzi, Fabiola Moretti, Francesca R. D’Amato
Publikováno v:
Biomolecules, Vol 12, Iss 4, p 532 (2022)
Epidemiological evidence indicates that stress and aversive psychological conditions can affect cancer progression, while well-being protects against it. Although a large set of studies have addressed the impact of stress on cancer, not much is known
Externí odkaz:
https://doaj.org/article/e946b81dbb544bd886d71f784231de57
Autor:
Silvia Middei
Publikováno v:
Brain Sciences, Vol 12, Iss 2, p 207 (2022)
Imaging in neurosciences allows for the visual representation of micro- and macro-components of the central (CNS) and peripheral (PNS) nervous systems with the intent of investigating their morphology and function, to provide diagnosis and prognosis
Externí odkaz:
https://doaj.org/article/373400e09ad3435f9a65d5b424b8239d
Publikováno v:
Brain Sciences, Vol 11, Iss 9, p 1245 (2021)
Sarcopenia, a geriatric syndrome involving loss of muscle mass and strength, is often associated with the early phases of Alzheimer’s disease (AD). Pathological hallmarks of AD including amyloid β (Aβ) aggregates which can be found in peripheral
Externí odkaz:
https://doaj.org/article/3cb5f8404afc4a2e9ecfe9f56ab2d07c
Autor:
Ingrid Ehrmann, Matthew R. Gazzara, Vittoria Pagliarini, Caroline Dalgliesh, Mahsa Kheirollahi-Chadegani, Yaobo Xu, Eleonora Cesari, Marina Danilenko, Marie Maclennan, Kate Lowdon, Tanja Vogel, Piia Keskivali-Bond, Sara Wells, Heather Cater, Philippe Fort, Mauro Santibanez-Koref, Silvia Middei, Claudio Sette, Gavin J. Clowry, Yoseph Barash, Mark O. Cunningham, David J. Elliott
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3269-3280 (2016)
The brain is made up of trillions of synaptic connections that together form neural networks needed for normal brain function and behavior. SLM2 is a member of a conserved family of RNA binding proteins, including Sam68 and SLM1, that control splicin
Externí odkaz:
https://doaj.org/article/f0ae21a2845440f5b5bb4825a77a395e
Autor:
Annabella Pignataro, Silvia Middei
Publikováno v:
Neural Plasticity, Vol 2017 (2017)
Neuronal activity has a strong causal role in the production and release of the neurotoxic β-amyloid peptide (Aβ). Because of this close link, gradual accumulation of Aβ into amyloid plaques has been reported in brain areas with intense neuronal a
Externí odkaz:
https://doaj.org/article/e3499bbb943740e896ec67e54743e210
Publikováno v:
Neural Plasticity, Vol 2015 (2015)
Experience modifies synaptic connectivity through processes that involve dendritic spine rearrangements in neuronal circuits. Although cAMP response element binding protein (CREB) has a key function in spines changes, its role in activity-dependent r
Externí odkaz:
https://doaj.org/article/3170e4cb24cf4462b1019f2b7670fb18