Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Silvia, Fademrecht"'
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0189646 (2017)
The currently known protein sequences are not distributed equally in sequence space, but cluster into families. Analyzing the cluster size distribution gives a glimpse of the large and unknown extant protein sequence space, which has been explored du
Externí odkaz:
https://doaj.org/article/7d916cd016534bae92fb76a5bf15d709
Autor:
Bettina M. Nestl, Silvia Fademrecht, Maike Lenz, Juergen Pleiss, Mahima Sharma, Gideon Grogan
Publikováno v:
Protein Engineering, Design and Selection. 31:109-120
We report the exploration of the evolutionary relationship between imine reductases (IREDs) and other dehydrogenases. This approach is informed by the sequence similarity between these enzyme families and the recently described promiscuous activity o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a51d2a8f4fb275ed7a89a44e79e117c7
https://doi.org/10.1093/protein/gzy006
https://doi.org/10.1093/protein/gzy006
Publikováno v:
Journal of Molecular Catalysis B: Enzymatic. 133:S243-S249
The direct hydration of C C bonds to yield alcohols or the reverse dehydration is chemically challenging but highly sought after. Recently, oleate hydratases (OAHs) gained attention as biocatalytic alternatives capable of hydrating isolated, non-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1221e61e5fc49e30dab848229d7577a0
https://doi.org/10.1016/j.molcatb.2017.01.010
https://doi.org/10.1016/j.molcatb.2017.01.010
Publikováno v:
Antimicrobial Agents and Chemotherapy. 60:2709-2717
The Lactamase Engineering Database ( www.LacED.uni-stuttgart.de ) was developed to facilitate the classification and analysis of TEM β-lactamases. The current version contains 474 TEM variants. Two hundred fifty-nine variants form a large scale-free
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f0c2fef23ba83de432eabac3edae90c
https://doi.org/10.1128/aac.02930-15
https://doi.org/10.1128/aac.02930-15
Publikováno v:
Proteins: Structure, Function, and Bioinformatics. 84:600-610
Chiral amines are valuable building blocks for the production of a variety of pharmaceuticals, agrochemicals and other specialty chemicals. Only recently, imine reductases (IREDs) were discovered which catalyze the stereoselective reduction of imines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70a87c8b2d322e39155e0295ca33a682
https://doi.org/10.1002/prot.25008
https://doi.org/10.1002/prot.25008
Autor:
Stephan C. Hammer, Silvia Fademrecht, Sebastian Gergel, Rebecca M. Demming, Bernhard Hauer, Jürgen Pleiss, Bettina M. Nestl
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
The direct enantioselective addition of water to unactivated alkenes could simplify the synthesis of chiral alcohols and solve a long‐standing challenge in catalysis. Here we report that an engineered fatty acid hydratase can catalyze the asymmetri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a60aaf51cd652103f49cc4a1594a274c
Autor:
Jürgen Pleiss, Silvia Fademrecht
Publikováno v:
Einführung in die Enzymtechnologie ISBN: 9783662576182
Die Struktur und die Funktion von Enzymen lassen sich durch zwei komplementare Methoden modellieren. In der datengetriebenen Modellierung werden experimentelle Daten zur Sequenz, Struktur und Funktion in Datenbanken erfasst und statistisch ausgewerte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::280f5ceec52524c72e5310cfd963496a
https://doi.org/10.1007/978-3-662-57619-9_3
https://doi.org/10.1007/978-3-662-57619-9_3
Autor:
Guido Reina, Tobias Kulschewski, Thomas Ertl, Florian Friess, Michael Krone, Katrin Scharnowski, Jürgen Pleiss, Silvia Fademrecht
Publikováno v:
IEEE transactions on visualization and computer graphics. 23(1)
We present Molecular Surface Maps, a novel, view-independent, and concise representation for molecular surfaces. It transfers the well-known world map metaphor to molecular visualization. Our application maps the complex molecular surface to a simple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a4027cb14b102a667c0930f9fa4655
https://pubmed.ncbi.nlm.nih.gov/27875185
https://pubmed.ncbi.nlm.nih.gov/27875185
Publikováno v:
Proteins. 84(5)
Chiral amines are valuable building blocks for the production of a variety of pharmaceuticals, agrochemicals and other specialty chemicals. Only recently, imine reductases (IREDs) were discovered which catalyze the stereoselective reduction of imines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3a98b997a9735e9ccd015c913e1e3875
https://pubmed.ncbi.nlm.nih.gov/26857686
https://pubmed.ncbi.nlm.nih.gov/26857686
Autor:
Philipp N. Scheller, Bernhard Hauer, Nicholas J. Turner, Jürgen Pleiss, Friedemann Leipold, Silvia Fademrecht, Sebastian Hofelzer, Bettina M. Nestl
Publikováno v:
Scheller, P N, Fademrecht, S, Hofelzer, S, Pleiss, J, Leipold, F, Turner, N, Nestl, B & Hauer, B 2014, ' Enzyme Toolbox: Novel Enantiocomplementary Imine Reductases ', CHEMBIOCHEM, vol. 15, no. 15, pp. 2201-2204 . https://doi.org/10.1002/cbic.201402213
Reducing reactions are among the most useful transformations for the generation of chiral compounds in the fine-chemical industry. Because of their exquisite selectivities, enzymatic approaches have emerged as the method of choice for the reduction o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fcae4fec17c8b42f812080648e6f415
https://pubmed.ncbi.nlm.nih.gov/25163890
https://pubmed.ncbi.nlm.nih.gov/25163890