Zobrazeno 1 - 10
of 139
pro vyhledávání: '"Silvia, Buonamici"'
Autor:
Dingxiao Zhang, Qiang Hu, Xiaozhuo Liu, Yibing Ji, Hsueh-Ping Chao, Yan Liu, Amanda Tracz, Jason Kirk, Silvia Buonamici, Ping Zhu, Jianmin Wang, Song Liu, Dean G. Tang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Dysregulation of mRNA alternative splicing is prevalent in cancers. Here, the authors characterized the landscape of aberrant alternative splicing during the development of prostate cancer, progression and therapeutic resistance and show that splicin
Externí odkaz:
https://doaj.org/article/7650acc90f58486d8e0f1601efde26ba
Autor:
Daniel Aird, Teng Teng, Chia-Ling Huang, Ermira Pazolli, Deepti Banka, Kahlin Cheung-Ong, Cheryl Eifert, Craig Furman, Zhenhua Jeremy Wu, Michael Seiler, Silvia Buonamici, Peter Fekkes, Craig Karr, James Palacino, Eunice Park, Peter G. Smith, Lihua Yu, Yoshiharu Mizui, Markus Warmuth, Agustin Chicas, Laura Corson, Ping Zhu
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Small molecule modulators of RNA splicing have therapeutic potential in tumours bearing spliceosome mutations. Here, the authors identify BCL2 genes have differential sensitivities to SF3b-targeting splicing modulators and combination of SF3b-targeti
Externí odkaz:
https://doaj.org/article/3d3b4213a3e7400997cdfc63d11b14e8
Autor:
Rocco Sciarrillo, Anna Wojtuszkiewicz, Btissame El Hassouni, Niccola Funel, Paolo Gandellini, Tonny Lagerweij, Silvia Buonamici, Maxime Blijlevens, Eveline A. Zeeuw van der Laan, Nadia Zaffaroni, Marcello Deraco, Shigeki Kusamura, Tom Würdinger, Godefridus J. Peters, Carla F.M. Molthoff, Gerrit Jansen, Gertjan J.L. Kaspers, Jacqueline Cloos, Elisa Giovannetti
Publikováno v:
EBioMedicine, Vol 39, Iss , Pp 215-225 (2019)
Introduction: Therapeutic options for diffuse malignant peritoneal mesothelioma (DMPM) are limited to surgery and locoregional chemotherapy. Despite improvements in survival rates, patients eventually succumb to disease progression. We investigated s
Externí odkaz:
https://doaj.org/article/db0ee27e25b648199a41ba7a10090d42
Autor:
Konstantinos Tzelepis, Etienne De Braekeleer, Demetrios Aspris, Isaia Barbieri, M. S. Vijayabaskar, Wen-Hsin Liu, Malgorzata Gozdecka, Emmanouil Metzakopian, Hamish D. Toop, Monika Dudek, Samuel C. Robson, Francisco Hermida-Prado, Yu Hsuen Yang, Roya Babaei-Jadidi, Dimitrios A. Garyfallos, Hannes Ponstingl, Joao M. L. Dias, Paolo Gallipoli, Michael Seiler, Silvia Buonamici, Binje Vick, Andrew J. Bannister, Roland Rad, Rab K. Prinjha, John C. Marioni, Brian Huntly, Jennifer Batson, Jonathan C. Morris, Cristina Pina, Allan Bradley, Irmela Jeremias, David O. Bates, Kosuke Yusa, Tony Kouzarides, George S. Vassiliou
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
SRPK1, a kinase involved in splicing regulation, is a potential therapeutic target for AML patients. Here, the authors show that SRPK1 inhibition changes isoform levels of key epigenetic regulators, including BRD4, and it has anti-tumor effects speci
Externí odkaz:
https://doaj.org/article/1853a1ced0ff46dfaf75bec9896c8581
Autor:
Anant A. Agrawal, Michael Seiler, Lindsey T. Brinton, Rose Mantel, Rosa Lapalombella, Jennifer A. Woyach, Amy J. Johnson, Ping Zhu, Markus Warmuth, Lihua Yu, John C. Byrd, Peter G. Smith, James S. Blachly, Silvia Buonamici
Publikováno v:
Blood Advances, Vol 1, Iss 15, Pp 995-1000 (2017)
Externí odkaz:
https://doaj.org/article/b8e285b935314e6fbf1de8e2ffe50316
Autor:
Teng Teng, Jennifer HC Tsai, Xiaoling Puyang, Michael Seiler, Shouyong Peng, Sudeep Prajapati, Daniel Aird, Silvia Buonamici, Benjamin Caleb, Betty Chan, Laura Corson, Jacob Feala, Peter Fekkes, Baudouin Gerard, Craig Karr, Manav Korpal, Xiang Liu, Jason T. Lowe, Yoshiharu Mizui, James Palacino, Eunice Park, Peter G. Smith, Vanitha Subramanian, Zhenhua Jeremy Wu, Jian Zou, Lihua Yu, Agustin Chicas, Markus Warmuth, Nicholas Larsen, Ping Zhu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
A number of natural occurring small-molecule splicing modulators are known. Here, the authors combine chemogenomic, structural and biochemical methods and show that these compounds also target the spliceosome-associated protein PHF5A and propose a po
Externí odkaz:
https://doaj.org/article/bcd02552d59140f1871d75acbfffec14
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Supplementary Figures S1-S8 with legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec467d08f4794ac5f85ded009f95a31
https://doi.org/10.1158/2159-8290.22541210.v1
https://doi.org/10.1158/2159-8290.22541210.v1
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Supplementary Tables 1-6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4cf23850ead9d18cd22d06c66aecea
https://doi.org/10.1158/2159-8290.22541204
https://doi.org/10.1158/2159-8290.22541204
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive leukemia of plasmacytoid dendritic cells (pDC). BPDCN occurs at least three times more frequently in men than in women, but the reasons for this sex bias are unknown. Here, studyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d7f9d5d3f428fa805864e0d5204040
https://doi.org/10.1158/2159-8290.c.6549572
https://doi.org/10.1158/2159-8290.c.6549572
Autor:
Andrew A. Lane, H. Phillip Koeffler, Omar Abdel-Wahab, Francine Garnache-Ottou, Naveen Pemmaraju, Marina Konopleva, Henry Yang, Peter S. Hammerman, David M. Weinstock, Pier Paolo Piccaluga, Fabrice Jardin, Elizabeth A. Morgan, Abner Louissaint, Scott B. Lovitch, Silvia Buonamici, Michael Seiler, Sabeha Biichle, Fanny Angelot-Delettre, Yvonne Y. Li, Jia Li, Mahmoud Ghandi, Gabriel K. Griffin, Sunhee S. Kim, Justin Taylor, Lucia Cabal-Hierro, Christopher M. Kenyon, Christopher A.G. Booth, Vikas Madan, Sun Sook Chung, Katsuhiro Togami
DNA sequences
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18d61c9709474767dec1a2bb0d3c8eb0
https://doi.org/10.1158/2159-8290.22541207
https://doi.org/10.1158/2159-8290.22541207