Zobrazeno 1 - 10 of 74 pro vyhledávání: '"Silvestro Duprè"'
1
Synthesis and activity of the glutathione analogue γ-(L-γ-azaglutamyl)-L-cysteinyl-glycine
Autor: D. Rossi, G. Luisi, F. Pinnen, Silvestro Duprè, Gino Lucente, A. Calcagni
Publikováno v: International Journal of Peptide and Protein Research. 46:434-439
The backbone-modified glutathione analogue gamma-(L-gamma-azaglutamyl)-L-cysteinyl-glycine 7, characterized by the presence of a NHCONH urea linkage deriving from the replacement of the native Glu gamma-CH2 with the aza (NH) group, was synthesized an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d69d1800da4375111d94cf800cd4cdf
https://doi.org/10.1111/j.1399-3011.1995.tb01078.x
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2
Antioxidant Properties of Sulfinates: Protective Effect of Hypotaurine on Peroxynitrite-Dependent Damage
Autor: Silvestro Duprè, Mario Fontana, Laura Pecci, Doriano Cavallini
Publikováno v: Neurochemical research 29 (2004): 111–116. doi:10.1023/B:NERE.0000010439.99991.cf
info:cnr-pdr/source/autori:Fontana M, Pecci L, Duprè S, Cavallini D./titolo:Antioxidant properties of sulfinates: protective effect of hypotaurine on peroxynitrite-dependent damage./doi:10.1023%2FB:NERE.0000010439.99991.cf/rivista:Neurochemical research/anno:2004/pagina_da:111/pagina_a:116/intervallo_pagine:111–116/volume:29
It has been proposed that hypotaurine may function as an antioxidant in vivo. We investigated whether this compound can act as protective agent able to prevent damage from peroxynitrite, a strong oxidizing and nitrating agent that reacts with several
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::110169dcfc935044488cbee7a50b262d
https://doi.org/10.1023/b:nere.0000010439.99991.cf
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3
Synthesis and biological evaluation of the disulfide form of the glutathione analogue γ-(l-glutamyl)-l-cysteinyl-l-aspartyl-l-cysteine
Autor: Antonio Di Stefano, Alessandra Spirito, Ivana Cacciatore, Enrico Morera, Silvestro Duprè, Francesco Pinnen
Publikováno v: Bioorganic Chemistry. 31:109-121
By using the chain to chain mode of cyclization the title glutathione analogue ( 4 ), containing the 11-membered disulfide ring replacing the native -Cys-Gly fragment, has been synthesized and characterized together with its reduced dithiol form γ-G
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a98d42313607153699ba4246a5b34064
https://doi.org/10.1016/s0045-2068(03)00022-1
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4
Proline–Glutamate Chimeras in Isopeptides. Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues
Autor: Anna Maria Caccuri, Alessandra Spirito, Adriano Mollica, Francesco Pinnen, Giorgio Ricci, Ivana Cacciatore, Mario Paglialunga Paradisi, Gino Lucente, Silvestro Duprè, Antonio Di Stefano
Publikováno v: Bioorganic & medicinal chemistry
11 (2003): 1677–1683.
info:cnr-pdr/source/autori:Paglialunga Paradisi M., Mollica A., Cacciatore I., Di Stefano A., Pinnen F., Caccuri A.M., Ricci G., Duprè S., Spirito A., Lucente G./titolo:Proline-Glutamate Chimeras in Isopeptides., Synthesis and Biological Evaluation of Conformationally Restricted Glutathione Analogues/doi:/rivista:Bioorganic & medicinal chemistry (Print)/anno:2003/pagina_da:1677/pagina_a:1683/intervallo_pagine:1677–1683/volume:11
The two novel diastereoisomeric glutathione analogues 1 and 2 have been designed and synthesized by replacing the native y-glutamylic moiety with the conformational rigid skeleton of cis- or trans-4-carboxy-L-proline residue. Both analogues have been
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2106572ff60d029ec6b39052878b000c
https://doi.org/10.1016/s0968-0896(03)00041-5
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5
Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue
Autor: Grazia Luisi, A. Giorgi, Luigi Brunetti, Francesco Pinnen, Alessandra Spirito, Lucia Recinella, Silvestro Duprè, Ivana Cacciatore, P. Sozio, A. Di Stefano, Giustino Orlando, Barbara Michelotto
Publikováno v: Il Farmaco (Pavia) 57 (2002): 479–486.
info:cnr-pdr/source/autori:Brunetti L., Cacciatore I., Di Stefano A., Duprè S., Giorgi A., Luisi G., Michelotto B., Orlando G., Pinnen F., Recinella L., Sozio P., Spirito A./titolo:Synthesis and biological evaluation of a novel pyroglutamyl-modified TRH analogue/doi:/rivista:Il Farmaco (Pavia)/anno:2002/pagina_da:479/pagina_a:486/intervallo_pagine:479–486/volume:57
The TRH analogue 3, incorporating the (S)-isothiazolidine-1,1-dioxide-3-carboxylic acid (1) moiety in place of the native L-pyroglutamic acid (pGlu) residue, has been synthesized and fully characterized by 1H and 13C NMR. The effects of replacing pGl
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e765959e8ae6f8f304c1c120dc06f014
https://doi.org/10.1016/s0014-827x(02)01232-6
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6
Glutathione metabolism in Candida albicans resistant strains to fluconazole and micafungin
Autor: Anna Teresa Palamara, Elisabetta Vavala, Marisa Colone, Giuseppina Mignogna, Alberto Macone, Giuseppina Pitari, Silvestro Duprè, Annarita Stringaro, Bruno Maras, Letizia Angiolella
Publikováno v: PLoS ONE, Vol 9, Iss 6, p e98387 (2014)
PLoS ONE
Currently available therapies for candidiasis are based on antifungal drugs belonging to azole and echinocandin families that interfere with different aspects of fungal metabolism. These drugs, beyond their specific effects, elicit also a cellular st
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e573c9e8ecb80a93a70251bb6fb28f85
http://europepmc.org/articles/PMC4045664?pdf=render
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7
Ψ(SO2NH) transition state isosteres of peptides. Synthesis and bioactivity of sulfonamido pseudopeptides related to carnosine
Autor: Grazia Luisi, Silvestro Duprè, A. Calcagni, Antonio Di Stefano, D. Rossi, Alessandra Spirito, Francesco Pinnen, Pier Giuseppe Ciattini
Publikováno v: Il Farmaco. 54:673-677
This paper reports the synthesis of tauryl dipeptides related to carnosine. In particular H-Tau-His-OH (5), H-Tau-His(π-Me)-OH (6) and H-Tau-His(τ-Me)-OH (9) are described. The enzyme carnosinase has been isolated from pig kidney and after purifica
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fddb932eac1de2c4129e801eafbff15
https://doi.org/10.1016/s0014-827x(99)00079-8
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8
Hypotaurine disproportionation reaction: Identification of products
Autor: K. Sugahara, Silvestro Duprè, Alessandra Spirito, Francesco Pinnen, Hiroyuki Kodama
Publikováno v: Amino Acids. 15:363-372
Hypotaurine, concentrated under reduced pressure in HCl solution, partially (30-40%) degrades into taurine (about 30%), 2-aminoethyl-2-aminoethanethiolsulfonate (about 10%) and ethanolamine. The degradation products were identified using LC/APCI-MS,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b186dd9be26d9e2f5280c640ea39682b
https://doi.org/10.1007/bf01320900
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9
Synthesis and Characterization of a Dehydrogenation Product Arising from the Oxidation of Aminoethylcysteine Ketimine Decarboxylated Dimer
Autor: Igor Fochi, Mirella Nardini, R.M. Matarese, Silvestro Duprè, Aldo Caiazzo, Alberto Macone, A. Antonucci
Publikováno v: Journal of Natural Products. 70:1046-1048
While investigating the antioxidant properties of aminoethylcysteine ketimine decarboxylated dimer (1) (a natural substance occurring in biological fluids such as human urine and plasma and in bovine cerebellum), a previously unreported oxidation pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c078bcdaa87ed55e1395100739a4b3b6
https://doi.org/10.1021/np060641t
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10
Simultaneous determination of urinary cystathionine, lanthionine, and their cyclic compounds using liquid chromatography-mass spectrometry with atmospheric pressure chemical ionization
Autor: Kazunori Sugahara, Mario Fontana, Shirong Yu, Silvestro Duprè, Jianying Zhang, Tomiko Ageta, Hiroyuki Kodama
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 698:301-307
A measurement system for cystathionine (Cysta) lanthionine (LT), and S-(2-aminoethyl)-L-cysteine (AEC), and reduced products of their ketimines, perhydro-1,4-thiazepine-3,5-dicarboxylic acid (PHTZDC), 1,4-thiomorpholine-3,5-dicarboxylic acid (TMDA) a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3d0dd035066f51289ef7a1218b68d58
https://doi.org/10.1016/s0378-4347(97)00295-8
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