Identification of small-molecule ligand-binding sites on and in the ARNT PAS-B domain

Autor: Xu, Xingjian, Closson, Joseph D., Marcelino, Leandro Pimentel, Favaro, Denize C., Silvestrini, Marion L., Solazzo, Riccardo, Chong, Lillian T., Gardner, Kevin H.

Publikováno v: In Journal of Biological Chemistry September 2024 300(9)

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Gating residues govern ligand unbinding kinetics from the buried cavity in HIF-2α PAS-B.

Autor: Silvestrini ML; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Solazzo R; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-Università di Bologna, Bologna, Italy., Boral S; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA., Cocco MJ; Department of Pharmaceutical Sciences, University of California, Irvine, Irvine, California, USA.; Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California, USA., Closson JD; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA.; PhD Program in Biochemistry, CUNY Graduate Center, New York, New York, USA., Masetti M; Department of Pharmacy and Biotechnology, Alma Mater Studiorum-Università di Bologna, Bologna, Italy., Gardner KH; Structural Biology Initiative, CUNY Advanced Science Research Center, New York, New York, USA.; Department of Chemistry and Biochemistry, City College of New York, New York, New York, USA.; PhD Programs in Biochemistry, Biology, and Chemistry, CUNY Graduate Center, New York, New York, USA., Chong LT; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Publikováno v: Protein science : a publication of the Protein Society [Protein Sci] 2024 Nov; Vol. 33 (11), pp. e5198.