Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Silvestre Massimo Modestia"'
Autor:
Iguaracy Pinheiro‐de‐Sousa, Miriam Helena Fonseca‐Alaniz, Girolamo Giudice, Iuri Cordeiro Valadão, Silvestre Massimo Modestia, Sarah Viana Mattioli, Ricardo Rosa Junior, Lykourgos‐Panagiotis Zalmas, Yun Fang, Evangelia Petsalaki, José Eduardo Krieger
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 12, Pp n/a-n/a (2023)
Abstract Endothelial dysfunction (ED) is critical in the development and progression of cardiovascular (CV) disorders, yet effective therapeutic targets for ED remain elusive due to limited understanding of its underlying molecular mechanisms. To add
Externí odkaz:
https://doaj.org/article/8cfb497568fa4b99a4e3e03e13a51c89
Autor:
Iguaracy Pinheiro-de-Sousa, Girolamo Giudice, Miriam Helena Fonseca-Alaniz, Silvestre Massimo Modestia, Sarah Viana Mattioli, Yun Fang, Evangelia Petsalaki, Jose E. Krieger
Code to generate the in silico KO prioritization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3969dcc30d0eb53c50bcd15a43671c7a
Autor:
Iguaracy Pinheiro-de-Sousa, Girolamo Giudice, Miriam Helena Fonseca-Alaniz, Silvestre Massimo Modestia, Sarah Viana Mattioli, Yun Fang, Evangelia Petsalaki, Jose E. Krieger
Endothelial dysfunction (ED) is a hallmark of cardiovascular (CV) disorders and influences their progression; however, there are currently no direct therapeutic targets, primarily due to the lack of knowledge regarding ED’s molecular basis. We used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65aa79ade379b8b70bee3aeaa37d9aec
https://doi.org/10.1101/2022.11.17.516953
https://doi.org/10.1101/2022.11.17.516953
Autor:
Silvestre Massimo Modestia
Publikováno v:
Biblioteca Digital de Teses e Dissertações da USP
Universidade de São Paulo (USP)
instacron:USP
Universidade de São Paulo (USP)
instacron:USP
A insuficiência cardíaca (IC) é uma síndrome de elevada morbimortalidade, correspondendo a um grave problema de saúde pública. Uma das abordagens terapêuticas para IC consiste no uso de antagonistas do receptor de angiotensina II do tipo 1 (AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb34bcf387484254c54e9ba217e038b
https://doi.org/10.11606/t.9.2020.tde-20022020-095733
https://doi.org/10.11606/t.9.2020.tde-20022020-095733
Autor:
José Eduardo Krieger, Carlota de Oliveira Rangel-Yagui, Matheus Malta de Sá, Silvestre Massimo Modestia
Publikováno v:
ResearcherID
AT1 is a G protein-coupled receptor responsible for controlling blood pressure in the cardiovascular system. The binding of angiotensin II (AngII) causes Gq recruitment, while shear stress (SS) activates AT1 and causes ERK1/2 phosphorylation independ