Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Silverio Ruggieri"'
Autor:
Valerio Mori, Adolfo Amici, Francesca Mazzola, Michele Di Stefano, Laura Conforti, Giulio Magni, Silverio Ruggieri, Nadia Raffaelli, Giuseppe Orsomando
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e113939 (2014)
NAD plays essential redox and non-redox roles in cell biology. In mammals, its de novo and recycling biosynthetic pathways encompass two independent branches, the "amidated" and "deamidated" routes. Here we focused on the indispensable enzymes gating
Externí odkaz:
https://doaj.org/article/0fe49b77577e424a9fce9c0f8a6ae060
Autor:
Lucia Cialabrini, Silverio Ruggieri, Marat D Kazanov, Leonardo Sorci, Francesca Mazzola, Giuseppe Orsomando, Andrei L Osterman, Nadia Raffaelli
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65595 (2013)
We have recently identified the enzyme NMN deamidase (PncC), which plays a key role in the regeneration of NAD in bacteria by recycling back to the coenzyme the pyridine by-products of its non redox consumption. In several bacterial species, PncC is
Externí odkaz:
https://doaj.org/article/9e960e1018be4ea4a8dc015b7ecab28d
Autor:
Giuseppe Orsomando, Lucia Cialabrini, Adolfo Amici, Francesca Mazzola, Silverio Ruggieri, Laura Conforti, Lucie Janeckova, Michael P Coleman, Giulio Magni
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e53271 (2012)
A novel assay procedure has been developed to allow simultaneous activity discrimination in crude tissue extracts of the three known mammalian nicotinamide mononucleotide adenylyltransferase (NMNAT, EC 2.7.7.1) isozymes. These enzymes catalyse the sa
Externí odkaz:
https://doaj.org/article/e23865cca4fc4efbad968e00b4db03b7
Autor:
Federica Zamporlini, Luca Mazzoni, Michele Cianci, Sara Castiglioni, Patricia Carloni, F. Balducci, Pasquale Massimiliano Falcone, Silverio Ruggieri, Alessandra Giardinieri, Gabriele Minazzato, Nadia Raffaelli, Deborah Pacetti, Bruno Mezzetti, Michele Balzano, Natale G. Frega
Publikováno v:
The First Outstanding 50 Years of “Università Politecnica delle Marche” ISBN: 9783030338312
The growing awareness of the key role of nutrition to human health status has greatly contributed to the spread of a new feeding concept: the functional nutrition. Nowadays, the foods are not exclusively a source of energy for the performance of norm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cf1a02bc3f8ce7355a0497e6c36ccb6
https://doi.org/10.1007/978-3-030-33832-9_35
https://doi.org/10.1007/978-3-030-33832-9_35
Autor:
G. Orsomando, Adolfo Amici, Silverio Ruggieri, Francesca Mazzola, Federica Zamporlini, Nadia Raffaelli, Massimo Mozzon, Simone Ummarino
Publikováno v:
Food Chemistry. 221:161-168
Nicotinamide riboside, the most recently discovered form of vitamin B3, and its phosphorylated form nicotinamide mononucleotide, have been shown to be potent supplements boosting intracellular nicotinamide adenine dinucleotide (NAD) levels, thus prev
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1854:1138-1149
In addition to its role as a redox coenzyme, NAD is a substrate of various enzymes that split the molecule to either catalyze covalent modifications of target proteins or convert NAD into biologically active metabolites. The coenzyme bioavailability
Autor:
Nadia Raffaelli, G. Orsomando, Federica Zamporlini, Silverio Ruggieri, Francesca Mazzola, Adolfo Amici
Publikováno v:
FEBS Journal. 281:5104-5119
The redox coenzyme NAD(+) is also a rate-limiting co-substrate for several enzymes that consume the molecule, thus rendering its continuous re-synthesis indispensable. NAD(+) biosynthesis has emerged as a therapeutic target due to the relevance of NA
Autor:
Lucia Brunetti, G. Orsomando, Silverio Ruggieri, Giulio Magni, Michele Di Stefano, Adolfo Amici, Lucia Galassi
Publikováno v:
Biochimie. 94:300-309
Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesis of NAD+. Even though NaPRT activity has been des
Publikováno v:
Protein Science. 20:2047-2059
The PcF Toxin Family (Pfam 09461) includes the characterized phytotoxic protein PcF from Phytophthora cactorum, as well as several predicted protein effectors from other Phytophthora species recently identified by comparative genomics. Here we provid
Publikováno v:
Protein Science. 19:2440-2450
Nicotinamide mononucleotide adenylyltransferase (NMNAT) catalyzes the formation of NAD by means of nucleophilic attack by 5′-phosphoryl of NMN on the α-phosphoryl group of ATP. Humans possess three NMNAT isozymes (NMNAT1, NMNAT2, and NMNAT3) that