Multi-year analysis of the global preclinical antibacterial pipeline: trends and gaps.

Autor: Gigante V; AMR Division, World Health Organization, Geneva, Switzerland., Alm RA; Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator, Boston, Massachusetts, USA.; WHO Consultants to the WHO AMR Division, Geneva, Switzerland., Melchiorri D; Department of Physiology and Pharmacology, Sapienza University, Rome, Italy., Rocke T; WHO Consultants to the WHO AMR Division, Geneva, Switzerland., Arias CA; Center for Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA., Czaplewski L; Chemical Biology Ventures Ltd., Abingdon, United Kingdom., Fernandes P; National Biodefense Science Board, U.S. Department of Health and Human Services, Washington, DC, USA., Franceschi F; Global Antibiotic Research & Development Partnership, Geneva, Switzerland., Harbarth S; Infection Control Programme, Geneva University Hospitals, Geneva, Switzerland.; Faculty of Medicine, WHO Collaborating Center for Patient Safety, Geneva, Switzerland., Kozlov R; Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russia., Lienhardt C; Université de Montpellier, INSERM, Institut de Recherche pour le Développement, Montpellier, France., Ohmagari N; National Center for Global Health and Medicine, Tokyo, Japan., Ogilvie LA; Global Antimicrobial Resistance Research and Development Hub, Berlin, Germany., Paul M; Infectious Diseases, Rambam Health Care Campus, Haifa, Israel.; The Ruth and Bruce Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel., Rex JH; F2G, Limited, Eccles, United Kingdom.; AMR Solutions, Boston, Massachusetts, USA.; Advent Life Sciences, London, United Kingdom.; McGovern Medical School, The University of Health Science Center at Houston, Houston, Texas, USA., Silver LL; LL Silver Consulting, Springfield, New Jersey, USA., Spigelman M; Global Alliance for TB Drug Development, New York, New York, USA., Sati H; AMR Division, World Health Organization, Geneva, Switzerland., Cameron AM; AMR Division, World Health Organization, Geneva, Switzerland.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2024 Aug 07; Vol. 68 (8), pp. e0053524. Date of Electronic Publication: 2024 Jul 15.

Analysis of the Clinical Pipeline of Treatments for Drug-Resistant Bacterial Infections: Despite Progress, More Action Is Needed.

Autor: Butler MS; MSBChem Consulting, Brisbane, Queensland, Australia.; Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia., Gigante V; Antimicrobial Resistance Division, WHO, Geneva, Switzerland., Sati H; Antimicrobial Resistance Division, WHO, Geneva, Switzerland., Paulin S; Antimicrobial Resistance Division, WHO, Geneva, Switzerland., Al-Sulaiman L; Antimicrobial Resistance Division, WHO, Geneva, Switzerland., Rex JH; F2G Limited, Eccles, Manchester, United Kingdom.; McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA., Fernandes P; Scientific Advisory Committee, GARDP, Geneva, Switzerland.; The National Biodefense Science Board, U.S. Department of Health and Human Services, Washington, DC, USA., Arias CA; Center for Infectious Diseases Research, Houston Methodist Research Institute, Houston, Texas, USA.; Center for Infectious Diseases, UTHealth School of Public Health, Houston, Texas, USA., Paul M; Infectious Diseases Institute, Rambam Health Care Campus, Haifa, Israel.; The Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel., Thwaites GE; Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Oxford University, Oxford, United Kingdom., Czaplewski L; Chemical Biology Ventures Ltd., Abingdon, Oxfordshire, United Kingdom., Alm RA; CARB-X, Boston University, Boston, Massachusetts, USA., Lienhardt C; Université de Montpellier, INSERM, Institut de Recherche pour le Développement, Montpellier, France., Spigelman M; TB Alliance, New York, New York, USA., Silver LL; LL Silver Consulting, Springfield, New Jersey, USA., Ohmagari N; National Center for Global Health and Medicine, Tokyo, Japan., Kozlov R; Institute of Antimicrobial Chemotherapy, Smolensk State Medical University, Smolensk, Russia., Harbarth S; National Center for Infection Prevention, Swissnoso, Bern, Switzerland.; Infection Control Programme, Geneva University Hospitals and Faculty of Medicine, WHO Collaborating Center for Patient Safety, Geneva, Switzerland., Beyer P; Antimicrobial Resistance Division, WHO, Geneva, Switzerland.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2022 Mar 15; Vol. 66 (3), pp. e0199121. Date of Electronic Publication: 2022 Jan 10.

Setting Our Sights on Infectious Diseases.

Autor: De Rycker M; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Horn D; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Aldridge B; Tufts University School of Medicine , 136 Harrison Avenue , Boston , Massachusetts 02111 , United States., Amewu RK; Department of Chemistry , University of Ghana , P.O. Box LG56, Legon, Accra , Ghana., Barry CE 3rd; National Institute of Allergy and Infectious Diseases , National Institutes of Health , 9000 Rockville Pike , Bethesda , Maryland 20892 , United States., Buckner FS; Center for Emerging and Re-emerging Infectious Diseases (CERID) , University of Washington , MS 358061, 750 Republican Street , Rm E-606, Seattle , Washington 98109-4766 , United States., Cook S; School of Humanities , University of Glasgow , 1 University Gardens , Glasgow G12 8QQ , United Kingdom., Ferguson MAJ; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Gobeau N; Medicines for Malaria Venture (MMV) , PO Box 1826, 20 Route de Pré-Bois , 1215 Geneva 15, Switzerland., Herrmann J; Helmholtz Institute for Pharmaceutical Research Saarland, Department Microbial Natural Products , Saarland University , Campus E8.1, 66123 Saarbrücken , Germany.; German Centre for Infection Research , partner site Hannover-Braunschweig , Germany., Herrling P; Independent Consultant, Switzerland., Hope W; Institute of Translational Medicine , University of Liverpool , Liverpool L69 3BX , United Kingdom., Keiser J; Department of Medical Parasitology and Infection Biology , Swiss Tropical and Public Health Institute , Socinstrasse 57 , CH-4051 Basel , Switzerland.; University of Basel , CH-4001 Basel , Switzerland., Lafuente-Monasterio MJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World (DDW) , GlaxoSmithKline , Tres Cantos , Spain., Leeson PD; Paul Leeson Consulting Ltd. , United Kingdom., Leroy D; Medicines for Malaria Venture (MMV) , PO Box 1826, 20 Route de Pré-Bois , 1215 Geneva 15, Switzerland., Manjunatha UH; Novartis Institute for Tropical Diseases (NITD) , Novartis Institutes for BioMedical Research (NIBR) , 5300 Chiron Way , Emeryville , California 94608 , United States., McCarthy J; QIMR Berghofer Medical Research Institute , 300 Herston Road , Hertson , Queensland 4006 , Australia., Miles TJ; Tres Cantos Medicines Development Campus, Diseases of the Developing World (DDW) , GlaxoSmithKline , Tres Cantos , Spain., Mizrahi V; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa , University of Cape Town , Observatory, Cape Town 7925 , South Africa., Moshynets O; Biofilm Study Group , Institute of Molecular Biology and Genetics of National Academy of Sciences of Ukraine , 150 Zabolotnoho Street , Kiev 03143 , Ukraine., Niles J; School of Engineering , Massachusetts Institute of Technology , Building 1-206, 77 Massachusetts Avenue , Cambridge , Massachusetts 02139-4307 , United States., Overington JP; Medicines Discovery Catapult , Alderley Park, Alderley Edge, Cheshire SK10 4TG , United Kingdom., Pottage J; ViiV Healthcare , 980 Great West Road , Brentford , Middlesex TW8 9GS , United Kingdom., Rao SPS; Novartis Institute for Tropical Diseases (NITD) , Novartis Institutes for BioMedical Research (NIBR) , 5300 Chiron Way , Emeryville , California 94608 , United States., Read KD; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Ribeiro I; Drugs for Neglected Diseases Initiative (DNDi) , Chemin Louis-Dunant 15 , 1202 Genève , Switzerland., Silver LL; LL Silver Consulting , New Jersey , United States., Southern J; Lancaster Institute for the Contemporary Arts (LICA), The LICA Building , Lancaster University , Lancaster LA1 4YW , United Kingdom., Spangenberg T; Global Health Institute of Merck, Ares Trading S.A. , a subsidiary of Merck KGaA Darmstadt Germany , Route de Crassier 1 , 1262 Eysins , Switzerland., Sundar S; Department of Medicine, Institute of Medical Sciences , Banaras Hindu University , Varanasi 221005 , India., Taylor C; SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine and Wellcome Centre for Infectious Disease Research in Africa , University of Cape Town , Observatory, Cape Town 7925 , South Africa., Van Voorhis W; Center for Emerging and Re-emerging Infectious Diseases (CERID) , University of Washington , MS 358061, 750 Republican Street , Rm E-606, Seattle , Washington 98109-4766 , United States., White NJ; Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine , Mahidol University , 3/F, 60th Anniversary Chalermprakiat Building, 420/6 Rajvithi Road , Bangkok 10400, Thailand., Wyllie S; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Wyatt PG; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom., Gilbert IH; Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery , University of Dundee , Dundee DD1 5EH , United Kingdom.

Publikováno v: ACS infectious diseases [ACS Infect Dis] 2020 Jan 10; Vol. 6 (1), pp. 3-13. Date of Electronic Publication: 2019 Dec 06.

Depletion of essential mycobacterial gene glmM reduces pathogen survival and induces host-protective immune responses against tuberculosis.

Autor: Agarwal, Meetu^1,2 (AUTHOR) meetuagarwal2388@gmail.com, Bhaskar, Ashima³ (AUTHOR), Singha, Biplab¹ (AUTHOR), Mukhopadhyay, Suparba³ (AUTHOR), Pahuja, Isha³ (AUTHOR), Singh, Archna⁴ (AUTHOR), Chaturvedi, Shivam³ (AUTHOR), Agarwal, Nisheeth⁵ (AUTHOR), Dwivedi, Ved Prakash³ (AUTHOR), Nandicoori, Vinay Kumar^1,6 (AUTHOR) vinaykn@ccmb.res.in

Publikováno v: Communications Biology. 8/6/2024, Vol. 7 Issue 1, p1-12. 12p.

Volatile communication in Actinobacteria: a language for secondary metabolism regulation.

Autor: Cuervo, Lorena^1,2,3 (AUTHOR), Méndez, Carmen^1,2,3 (AUTHOR), Salas, José A.^1,2,3 (AUTHOR), Olano, Carlos^1,2,3 (AUTHOR), Malmierca, Mónica G.^1,2,3 (AUTHOR) monicagomal@yahoo.es

Publikováno v: Microbial Cell Factories. 6/18/2024, Vol. 23 Issue 1, p1-18. 18p.