Zobrazeno 1 - 10
of 341
pro vyhledávání: '"Silve, A. P."'
Autor:
de la Fuente, Jesus, Serrano, Guillermo, Veleiro, Uxía, Casals, Mikel, Vera, Laura, Pizurica, Marija, Pineda-Lucena, Antonio, Ochoa, Idoia, Vicent, Silve, Gevaert, Olivier, Hernaez, Mikel
Drug-target interaction (DTI) prediction is a challenging, albeit essential task in drug repurposing. Learning on graph models have drawn special attention as they can significantly reduce drug repurposing costs and time commitment. However, many cur
Externí odkaz:
http://arxiv.org/abs/2311.12670
Autor:
Irati Macaya, Marta Roman, Connor Welch, Rodrigo Entrialgo-Cadierno, Marina Salmon, Alba Santos, Iker Feliu, Joanna Kovalski, Ines Lopez, Maria Rodriguez-Remirez, Sara Palomino-Echeverria, Shane M. Lonfgren, Macarena Ferrero, Silvia Calabuig, Iziar A. Ludwig, David Lara-Astiaso, Eloisa Jantus-Lewintre, Elizabeth Guruceaga, Shruthi Narayanan, Mariano Ponz-Sarvise, Antonio Pineda-Lucena, Fernando Lecanda, Davide Ruggero, Purvesh Khatri, Enrique Santamaria, Joaquin Fernandez-Irigoyen, Irene Ferrer, Luis Paz-Ares, Matthias Drosten, Mariano Barbacid, Ignacio Gil-Bazo, Silve Vicent
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Drug combinations are key to circumvent resistance mechanisms compromising response to single anti-cancer targeted therapies. The implementation of combinatorial approaches involving MEK1/2 or KRASG12C inhibitors in the context of KRAS-mutat
Externí odkaz:
https://doaj.org/article/e4df0207a07b4df791d9fb4bec0b4c62
Autor:
Rodrigo Entrialgo-Cadierno, Cristina Cueto-Ureña, Connor Welch, Iker Feliu, Irati Macaya, Laura Vera, Xabier Morales, Sandra Vietti Michelina, Pietro Scaparone, Ines Lopez, Elodie Darbo, Oihane Erice, Adrian Vallejo, Haritz Moreno, Ainhoa Goñi-Salaverri, David Lara-Astiaso, Nils Halberg, Ivan Cortes-Dominguez, Elizabeth Guruceaga, Chiara Ambrogio, Fernando Lecanda, Silve Vicent
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-23 (2023)
Abstract Background The discovery of functionally relevant KRAS effectors in lung and pancreatic ductal adenocarcinoma (LUAD and PDAC) may yield novel molecular targets or mechanisms amenable to inhibition strategies. Phospholipids availability has b
Externí odkaz:
https://doaj.org/article/4f6be978317d4dc0ae3c2a262e7964af
Autor:
Doekhie, Aswin, Dattani, Rajeev, Chen, Yun-Chu, Yang, Yi, Smith, Andrew, Silve, Alex P., Koumanov, Francoise, Edler, Karen J., Marchbank, Kevin J., Elsen, Jean van den, Sartbaeva, Asel
Ensilication is a technology we developed that can physically stabilise proteins in silica without use of a pre-formed particle matrix. Stabilisation is done by tailor fitting individual proteins with a silica coat using a modified sol-gel process. B
Externí odkaz:
http://arxiv.org/abs/1811.12291
Akademický článek
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Akademický článek
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Akademický článek
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Autor:
Leticia Colyn, Gloria Alvarez-Sola, M. Ujue Latasa, Iker Uriarte, Jose M. Herranz, Maria Arechederra, George Vlachogiannis, Colin Rae, Antonio Pineda-Lucena, Andrea Casadei-Gardini, Federica Pedica, Luca Aldrighetti, Angeles López-López, Angeles López-Gonzálvez, Coral Barbas, Sergio Ciordia, Sebastiaan M. Van Liempd, Juan M. Falcón-Pérez, Jesus Urman, Bruno Sangro, Silve Vicent, Maria J. Iraburu, Felipe Prosper, Leonard J. Nelson, Jesus M. Banales, Maria Luz Martinez-Chantar, Jose J. G. Marin, Chiara Braconi, Christian Trautwein, Fernando J. Corrales, F. Javier Cubero, Carmen Berasain, Maite G. Fernandez-Barrena, Matias A. Avila
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Cholangiocarcinoma (CCA) is still a deadly tumour. Histological and molecular aspects of thioacetamide (TAA)-induced intrahepatic CCA (iCCA) in rats mimic those of human iCCA. Carcinogenic changes and therapeutic vulnerabilities i
Externí odkaz:
https://doaj.org/article/278c7dac66c24c988487ac905912005b
Autor:
Jean-Philippe Bertocchio, Natalie Grosset, Lionel Groussin, Peter Kamenický, Fabrice Larceneux, Anne Lienhardt-Roussie, Agnès Linglart, Gérard Maruani, Eric Mirallie, François Pattou, Riyad N H Seervai, Coralie Sido, Caroline Silve, Aurélie Vilfaillot, Antoine Tabarin, Marie-Christine Vantyghem, Pascal Houillier
Publikováno v:
Endocrine Connections, Vol 11, Iss 1, Pp 1-11 (2022)
Context: Recent guidelines have provided recommendations for the care of patients with chronic hypoparathyroidism. Very little is known about actual physicians’ practices or their adherence to such guidelines. Objective: To describe the physicians
Externí odkaz:
https://doaj.org/article/bf00ba6ee5f64061ab750abbff025138
Publikováno v:
Monções, Vol 10, Iss 20, Pp 432-457 (2021)
A chegada de Donald Trump à presidência dos EUA reanimou debates sobre a gestão das fronteiras do país, principalmente com o México. A partir de um estudo qualitativo, com uma revisão bibliográfica, o artigo demonstra que, apesar da mudança d
Externí odkaz:
https://doaj.org/article/5972beed397448ac8645e4eda8e4e06f