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pro vyhledávání: '"Silvano Machado de Brito"'
Autor:
E. B. M. I. Peixoto, Patricia Janino, Sergio Mota da Silva, José B. Lopes de Faria, Silvano Machado de Brito, Eduardo Homsi
Publikováno v:
American journal of nephrology. 33(1)
Background/Aims: p53 is a transcriptional factor that responds to severe cell damage promoting the transcription of proapoptotic and prooxidant genes. In this study, we evaluated the role of p53 activation in glycerol-induced acute kidney injury (Gly
Silymarin exacerbates p53-mediated tubular apoptosis in glycerol-induced acute kidney injury in rats
Publikováno v:
Renal failure. 32(5)
Silymarin is an herbal extract with antioxidant properties that can reduce oxidative stress-mediated injuries in murine models of liver, heart, and kidney diseases. Silymarin can also increase p53-mediated cellular apoptosis in vitro. We tested the e