Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Silvano Brienza"'
Autor:
Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, Maximilien Murone
Legend for Supplementary Tables:1,2,3,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ca53742a30df58de5c8e279ec0d7a6
https://doi.org/10.1158/1535-7163.22503606
https://doi.org/10.1158/1535-7163.22503606
Autor:
Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, Maximilien Murone
Suppl. Table 1. Binding mode of Debio 0617B to ABL. Suppl. Table 2. Physico-chemical and early ADME profile of Debio 0617B. Suppl. Table 3. Debio 0617B activity on a panel of 21 cancer cell lines. Suppl. Table 4. PK/PD Profile of Debio 0617B in mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10dfcd8f345331fe23adf2ab75896daa
https://doi.org/10.1158/1535-7163.22503609.v1
https://doi.org/10.1158/1535-7163.22503609.v1
Autor:
Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, Maximilien Murone
Suppl. Fig. 1 Characterization for pSTAT3 activation in cancer cell lines responding to Debio 0617B in vitro by Western blot analysis.Suppl. Fig. 2 A-C. Efficacy studies with Debio 0617B in A549, A2058 and A431 models: body weight loss/gain (%). Supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7752e86a76f3ca53bb26b6deb49f8a08
https://doi.org/10.1158/1535-7163.22503615
https://doi.org/10.1158/1535-7163.22503615
Autor:
Andres McAllister, Murali Ramachandra, Faye M. Johnson, Courtney Nicholas, Olivier Michielin, Vincent Zoete, Michel Aguet, Marc Lang, Peter Traxler, Silvano Brienza, Yogeshwar Bachhav, Stefania Rigotti, Samiulla Dhodheri, Sivapriya Marappan, Saumitra Sengupta, Girish Daginakatte, Shankar J. Shetty, Raghuveer Ramachandra, Antoine Attinger, Anne Vaslin Chessex, Maximilien Murone
Legend for Supplementary Figures:1A,1B,1C,1D 2A,2B,2C;3A,3B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46abf69d55ecd93441ab433c3d829f7e
https://doi.org/10.1158/1535-7163.22503612.v1
https://doi.org/10.1158/1535-7163.22503612.v1
Autor:
Xu-Shan Sun, Yungan Tao, Christophe Le Tourneau, Yoann Pointreau, Christian Sire, Marie-Christine Kaminsky, Alexandre Coutte, Marc Alfonsi, Pierre Boisselier, Laurent Martin, Jessica Miroir, Jean-Francois Ramee, Jean-Pierre Delord, Florian Clatot, Frederic Rolland, Julie Villa, Nicolas Magne, Olgun Elicin, Elisabeta Gherga, France Nguyen, Cedrick Lafond, Guillaume Bera, Valentin Calugaru, Lionnel Geoffrois, Bruno Chauffert, Angela Zubel, Claudio Zanna, Silvano Brienza, Philippa Crompton, Elisabeth Rouits, Kathrin Gollmer, Sergio Szyldergemajn, Jean Bourhis
Publikováno v:
The Lancet Oncology. 21:1173-1187
Summary Background Debio 1143 is an orally available antagonist of inhibitor of apoptosis proteins with the potential to enhance the antitumour activity of cisplatin and radiotherapy. The radiosensitising effect of Debio 1143 is mediated through casp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89341b4fa426c806cabcec65f97ca451
https://doi.org/10.1016/s1470-2045(20)30327-2
https://doi.org/10.1016/s1470-2045(20)30327-2
Autor:
M-C. Kaminsky-Forrett, Silvano Brienza, Florian Clatot, Frederic Rolland, Marc Alfonsi, Jean Bourhis, Christian Sire, Caroline Even, P. Boisselier, Yungan Tao, Laurent Martin, Alexandre Coutte, Jessica Miroir, Sergio Szyldergemajn, Philippa Crompton, X. Sun, C. Le Tourneau, Y. Pointreau, J.-P. Delord
Background Debio 1143 is an antagonist of Inhibitor of Apoptosis Proteins (IAP) with the potential to enhance the antitumor activity of cisplatin and radiotherapy (RT) through a radiosensitizing effect that is mediated via caspase activation and TNF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23ac1374fa1bf1c563be93f94c93b3a
https://hal-u-picardie.archives-ouvertes.fr/hal-03600473
https://hal-u-picardie.archives-ouvertes.fr/hal-03600473
Autor:
Silvano Brienza, Vincent Zoete, Marc Lang, Saumitra Sengupta, Antoine Attinger, Michel Aguet, Maximilien Murone, Stefania Rigotti, Olivier Michielin, Yogeshwar Bachhav, Faye M. Johnson, Andres McAllister, Girish Daginakatte, Anne Vaslin Chessex, Sivapriya Marappan, Raghuveer Ramachandra, Peter Traxler, Courtney Nicholas, Shankar Jayaram Shetty, Murali Ramachandra, Samiulla Dhodheri
Publikováno v:
Molecular Cancer Therapeutics. 15:2334-2343
Tumor survival, metastases, chemoresistance, and escape from immune responses have been associated with inappropriate activation of STAT3 and/or STAT5 in various cancers, including solid tumors. Debio 0617B has been developed as a first-in-class kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f530e310b747b3114279b798dfaec2ea
https://doi.org/10.1158/1535-7163.mct-15-0974
https://doi.org/10.1158/1535-7163.mct-15-0974
Autor:
Grégoire Vuagniaux, Jérôme Sarini, Sergio Szyldergemajn, Caroline Hoffmann, Elisabeth Rouits, Carlos Gomez-Roca, Philippe Rochaix, Silvano Brienza, Dalit Rechavi-Robinson, Franck Brichory, Christophe Le Tourneau, Sébastien Vergez, Stephane Teman, Neus Basté Rotllan, Claudio Zanna, Bruno Gavillet, Caroline Even, Daniela Purcea, Jean-Pierre Delord, Sebastien Del Rizzo, Vincent Bize
Publikováno v:
Cancer Research. 79:5001-5001
Background: Inhibitor of Apoptosis Proteins (IAPs) regulate apoptosis and modulate NFκB signaling, which in turn drives the expression of genes involved in immune and inflammatory responses. Debio 1143 is an orally available antagonist of IAPs with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::781d488f3e7e6811792a42df28b28e94
https://doi.org/10.1158/1538-7445.am2019-5001
https://doi.org/10.1158/1538-7445.am2019-5001
Autor:
Miriam Alonso, Luis Paz-Ares, Claudio Zanna, Sandrine Hiret, Ruth Plummer, Jaafar Bennouna, Riccardo Belli, Daniela Purcea, Santiago Ponce-Aix, Enriqueta Felip, Jose Manuel Trigo, Jesus Corral Jaime, Jean-Pierre Delord, Nicolas Isambert, Hélène Senellart, Silvano Brienza, Mariano Provencio, Alex Martinez Marti, Virginia Calvo
Publikováno v:
Journal of Clinical Oncology. 32:TPS2632-TPS2632
TPS2632^ Background: Debio0932 is an oral second-generation Heat Shock Protein 90 (HSP90) inhibitor, structurally unrelated to geldanamycin. In multiple pre-clinical models Debio0932 has demonstrat...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::729baeb510e953306a6ec7ac5b70ba3a
https://doi.org/10.1200/jco.2014.32.15_suppl.tps2632
https://doi.org/10.1200/jco.2014.32.15_suppl.tps2632
Autor:
Anne Vaslin, Valerie Nicolas-Metral, Rebecca S. Heist, Josep Tabernero, Claudio Zanna, José Baselga, Leena Gandhi, Keith T. Flaherty, B. Adamo, Nobuya Ishii, Corinne Moulon, Yuko Aoki, Silvano Brienza, Hiroaki Tanaka, Martin H. Voss
Publikováno v:
Journal of Clinical Oncology. 32:TPS2629-TPS2629
TPS2629^ Background: Deregulated fibroblast growth factor receptor (FGFR) signalling is associated with tumorigenesis. Debio 1347 is an orally-available ATP competitive inhibitor of FGFR 1, 2 and 3...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::191ec12ff9edfbfd9c6e2bcb059ad13c
https://doi.org/10.1200/jco.2014.32.15_suppl.tps2629
https://doi.org/10.1200/jco.2014.32.15_suppl.tps2629