Zobrazeno 1 - 10
of 105
pro vyhledávání: '"Silvana Morello"'
Autor:
Caterina Giraulo, Lavinia Orlando, Elva Morretta, Antonia Voli, Paola Plaitano, Carla Cicala, Eugen Potaptschuk, Christa E. Müller, Alessandra Tosco, Maria Chiara Monti, Silvana Morello
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 177, Iss , Pp 117033- (2024)
Melanoma cells express high levels of CD73 that produce extracellular immunosuppressive adenosine. Changes in the CD73 expression occur in response to tumor environmental factors, contributing to tumor phenotype plasticity and therapeutic resistance.
Externí odkaz:
https://doaj.org/article/10068ff471c8423bb64dd250e802a916
Autor:
Caterina Giraulo, Roberta Turiello, Lavinia Orlando, Sonia Leonardelli, Jennifer Landsberg, Raffaella Belvedere, Georg Rolshoven, Christa E. Müller, Michael Hölzel, Silvana Morello
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 165, Iss , Pp 115225- (2023)
CD73 is the key enzyme in the generation of extracellular adenosine, a mediator involved in tumor progression, tumor immune escape and resistance to anti-cancer therapeutics. Microenvironmental conditions influence the expression of CD73 in tumor cel
Externí odkaz:
https://doaj.org/article/2d01d7fab2754c648cad5647ebf10af7
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Skin wound healing requires accurate therapeutic topical managements to accelerate tissue regeneration. Here, for the first time, we found that the association mesoglycan/VEGF has a strong pro-healing activity. In detail, this combination in
Externí odkaz:
https://doaj.org/article/45812c3071004dc69bcc3808584511c1
Autor:
Carla Cicala, Silvana Morello
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 13, p 11055 (2023)
Tissue inflammation is a dynamic process that develops step by step, in response to an injury, to preserve tissue integrity [...]
Externí odkaz:
https://doaj.org/article/d4f9340291574b388ffbdd1e1222e61b
Autor:
Elena De Marchi, Anna Pegoraro, Roberta Turiello, Francesco Di Virgilio, Silvana Morello, Elena Adinolfi
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
ATP and adenosine are key constituents of the tumor niche where they exert opposite and complementary roles. ATP can be released in response to cell damage or actively released by tumor cells and subsequently degraded into adenosine, which accumulate
Externí odkaz:
https://doaj.org/article/e176bc02db0345e7a0589c15adea8acb
Autor:
Mariaelena Capone, Gabriele Madonna, Ester Simeone, Paolo A Ascierto, Antonio Sorrentino, Roberta Turiello, Elva Morretta, Maria Chiara Monti, Rosa Azzaro, Silvana Morello, Pasquale Del Gaudio
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 3 (2022)
Background CD73 is an ectonucleotidase producing the immunosuppressor mediator adenosine. Elevated levels of circulating CD73 in patients with cancer have been associated with disease progression and poor response to immunotherapy. Immunosuppressive
Externí odkaz:
https://doaj.org/article/16eb3e6d99c6479e82f78953f59e5073
Autor:
Mariaelena Capone, Federica Fratangelo, Diana Giannarelli, Claudia Sorrentino, Roberta Turiello, Serena Zanotta, Domenico Galati, Gabriele Madonna, Marilena Tuffanelli, Luigi Scarpato, Antonio M. Grimaldi, Assunta Esposito, Rosa Azzaro, Antonio Pinto, Ernesta Cavalcanti, Aldo Pinto, Silvana Morello, Paolo A. Ascierto
Publikováno v:
Journal of Translational Medicine, Vol 18, Iss 1, Pp 1-10 (2020)
Abstract Background PD-1 blocking agents, such as nivolumab, have demonstrated clear anti-tumor effects and clinical benefits in a subset of patients with advanced malignancies. Nonetheless, more efforts are needed to identify reliable biomarkers for
Externí odkaz:
https://doaj.org/article/1d823bbfda724a32aa3ced2ae1f337c9
Autor:
Nunzia Novizio, Raffaella Belvedere, Elva Morretta, Richard Tomasini, Maria Chiara Monti, Silvana Morello, Antonello Petrella
Publikováno v:
Cancers, Vol 14, Iss 19, p 4764 (2022)
Among solid tumors, pancreatic cancer (PC) remains a leading cause of death. In PC, the protein ANXA1 has been identified as an oncogenic factor acting in an autocrine/paracrine way, and also as a component of tumor-deriving extracellular vesicles. H
Externí odkaz:
https://doaj.org/article/06d4258fa1604356ba0dfae733fbbe25
Autor:
Elisabetta Caiazzo, Ida Cerqua, Roberta Turiello, Maria Antonietta Riemma, Giacomo De Palma, Armando Ialenti, Fiorentina Roviezzo, Silvana Morello, Carla Cicala
Publikováno v:
Biomolecules, Vol 12, Iss 5, p 697 (2022)
Ecto-5′-nucleotidase (CD73), the ectoenzyme that together with CD39 is responsible for extracellular ATP hydrolysis and adenosine accumulation, regulates immune/inflammatory processes by controlling innate and acquired immunity cell functions. We p
Externí odkaz:
https://doaj.org/article/9c7f1405352345f4a50e8388e5517f73
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/4060fe43ea9846b4951c78bf6c6570db