Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Silvana Leit"'
Targeting the Cbl-b-Notch1 axis as a novel immunotherapeutic strategy to boost CD8+ T-cell responses
Autor:
Giulia Monticone, Zhi Huang, Fred Csibi, Silvana Leit, David Ciccone, Ameya S. Champhekar, Jermaine E. Austin, Deniz A. Ucar, Fokhrul Hossain, Salome V. Ibba, A. Hamid Boulares, Nicholas Carpino, Keli Xu, Samarpan Majumder, Barbara A. Osborne, Christine Loh, Lucio Miele
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
A critical feature of cancer is the ability to induce immunosuppression and evade immune responses. Tumor-induced immunosuppression diminishes the effectiveness of endogenous immune responses and decreases the efficacy of cancer immunotherapy. In thi
Externí odkaz:
https://doaj.org/article/f8e940e37817407f8336c28c349fbf51
Autor:
Silvana Leit, David Ciccone
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85da911b9012ba717cb41ea95726fde
https://doi.org/10.1136/jitc-2022-sitc2022.0460
https://doi.org/10.1136/jitc-2022-sitc2022.0460
Autor:
Silvana Leit, Jeremy R. Greenwood, Sayan Mondal, Samantha Carriero, Markus Dahlgren, Geraldine C. Harriman, Joshua J. Kennedy-Smith, Rosana Kapeller, Jon P. Lawson, Donna L. Romero, Angela V. Toms, Mee Shelley, Ronald T. Wester, William Westlin, Joshua J. McElwee, Wenyan Miao, Scott D. Edmondson, Craig E. Masse
Publikováno v:
Bioorganicmedicinal chemistry letters. 73
TYK2 is a member of the JAK family of kinases and a key mediator of IL-12, IL-23, and type I interferon signaling. These cytokines have been implicated in the pathogenesis of multiple inflammatory and autoimmune diseases such as psoriasis, rheumatoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::437201685fd71738ea69d006bd5f028b
https://pubmed.ncbi.nlm.nih.gov/35842205
https://pubmed.ncbi.nlm.nih.gov/35842205
Autor:
Giulia Monticone, Fred Csibi, Silvana Leit, David Ciccone, Ameya S. Champhekar, Jermaine E. Austin, Deniz A. Ucar, Fokhrul Hossain, Zhi Huang, Salome V. Ibba, A. Hamid Boulares, Nicholas Carpino, Samarpan Majumder, Keli Xu, Barbara A. Osborne, Christine Loh, Lucio Miele
A critical feature of cancer is the ability to induce immunosuppression and evade immune responses. Tumor-induced immunosuppression diminishes the efficacy of endogenous immune responses and decreases the efficacy of cancer immunotherapy. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f1499160016e9fd40cbe8738775d92d
https://doi.org/10.1101/2022.03.15.484378
https://doi.org/10.1101/2022.03.15.484378
Autor:
J. Kuai, Silvana Leit, Liang Tong, Byron DeLaBarre, H.J. Harwood Jr., Eric Therrien, S. Rafi, Jia Wei
Publikováno v:
Nature. 568:566-570
ATP-citrate lyase (ACLY) is a central metabolic enzyme and catalyses the ATP-dependent conversion of citrate and coenzyme A (CoA) to oxaloacetate and acetyl-CoA1–5. The acetyl-CoA product is crucial for the metabolism of fatty acids6,7, the biosynt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5bd109a25019c765bd3ab2063bb651
https://doi.org/10.1038/s41586-019-1094-6
https://doi.org/10.1038/s41586-019-1094-6
Autor:
Giulia Monticone, Fred Csibi, Silvana Leit, Jermaine E. Austin, Deniz A. Ucar, Fokhrul M. Hossain, Samarpan Majumder, Barbara A. Osborne, Christine Loh, Lucio Miele
Publikováno v:
Cancer Research. 82:2064-2064
Background: Tumor-induced immunosuppression is a way in which cancers evade the host immune response. In recent years, a great effort has been made in designing immunotherapies that can boost the immune system response against cancer. However, not al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d7eebb23ee81268cf5f5177a6a18123
https://doi.org/10.1158/1538-7445.am2022-2064
https://doi.org/10.1158/1538-7445.am2022-2064
Autor:
Fred Csibi-Levin, Silvana Leit, David L. Laughton, Tom Baker, Suzanne L. Jacques, Beth Browning, Angela V. Toms, Samantha Garside, Simon D'Archivio, Katarzyna Kopycka, Xiaohua Zhu, Allan M. Jordan, Stuart Thomson, Christine Loh, Peter Tummino, David N. Ciccone
Publikováno v:
Cancer Research. 82:589-589
Introduction: Casitas B-lineage lymphoma b (Cbl-b), a RING finger E3 ligase and a member of a highly conserved family of Cbl proteins, catalyzes the ubiquitination of substrate proteins to regulate multiple signaling events in a variety of cell types
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53a52ecbb63015d93d013097f6369635
https://doi.org/10.1158/1538-7445.am2022-589
https://doi.org/10.1158/1538-7445.am2022-589
Autor:
Raghavendra G. Mirmira, Piero Marchetti, Wenyan Miao, Anne Op De Beeck, Lorella Marselli, Decio L. Eizirik, Craig Masse, Carmella Evans-Molina, Silvana Leit, Angela Castela, Alexandra Coomans de Brachène
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11f6f5b055279c0d9b90e054ff7e4e64
https://doi.org/10.1111/dom.14104/v2/response1
https://doi.org/10.1111/dom.14104/v2/response1
Autor:
Jia Wei, Salma Rafi, Silvana Leit, Byron DeLaBarre, H. James Harwood, Jun Kuai, Eric Therrien, Liang Tong
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 75:a371-a371
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2354aa088e80115937463fedc3eda1f
https://doi.org/10.1107/s0108767319096387
https://doi.org/10.1107/s0108767319096387
Publikováno v:
Saúde em Debate, Vol 46, Iss 134, Pp 886-905 (2022)
ABSTRACT Although the National Health Service (NHS) and the Unified Health System (SUS) are systems with similar universal principles, they can show different political measure patterns in the pharmaceutical field. This paper aimed to provide a compa
Externí odkaz:
https://doaj.org/article/d95a51e433084b6aa0775a216320c6a7