Zobrazeno 1 - 10
of 187
pro vyhledávání: '"Silvana Gaudieri"'
Autor:
Curtis Cai, Jerome Samir, Mehdi R. Pirozyan, Thiruni N. Adikari, Money Gupta, Preston Leung, Brendan Hughes, Willem Van der Byl, Simone Rizzetto, Auda Elthala, Elizabeth Keoshkerian, Jean-Louis Palgen, Timothy Peters, Thi H. O. Nguyen, Raymond Louie, Katherine Kedzierska, Silvana Gaudieri, Rowena A. Bull, Andrew R. Lloyd, Fabio Luciani
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
The early immune response following exposure to HCV is not fully explored. Here the authors use single cell analysis and immune profiling to relate the infection sequence and immune response to early HCV infection showing that exhausted phenotypes of
Externí odkaz:
https://doaj.org/article/588f772ffcbf4737b2226e6c72bd6b81
Autor:
Matthew D. Parker, Hazel Stewart, Ola M. Shehata, Benjamin B. Lindsey, Dhruv R. Shah, Sharon Hsu, Alexander J. Keeley, David G. Partridge, Shay Leary, Alison Cope, Amy State, Katie Johnson, Nasar Ali, Rasha Raghei, Joe Heffer, Nikki Smith, Peijun Zhang, Marta Gallis, Stavroula F. Louka, Hailey R. Hornsby, Hatoon Alamri, Max Whiteley, Benjamin H. Foulkes, Stella Christou, Paige Wolverson, Manoj Pohare, Samantha E. Hansford, Luke R. Green, Cariad Evans, Mohammad Raza, Dennis Wang, Andrew E. Firth, James R. Edgar, Silvana Gaudieri, Simon Mallal, The COVID-19 Genomics UK (COG-UK) consortium, Mark O. Collins, Andrew A. Peden, Thushan I. de Silva
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Matthew Parker et al. use the ARTIC network tiled amplicon PCR and Oxford Nanopore sequencing of thousands of SARS-CoV-2 samples to detect subgenomic RNA changes in the B.1.1.7 lineage endemic in the UK in late 2020/early 2021. They discovered higher
Externí odkaz:
https://doaj.org/article/a4136fc5fe3f462ca4c6714d58abfce9
Autor:
Jennifer Currenti, Joshua Simmons, Jared Oakes, Silvana Gaudieri, Christian M. Warren, Rama Gangula, Eric Alves, Ramesh Ram, Shay Leary, Jesse D. Armitage, Rita M. Smith, Abha Chopra, Natasha B. Halasa, Mark A. Pilkinton, Spyros A. Kalams
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionA vaccine against influenza is available seasonally but is not 100% effective. A predictor of successful seroconversion in adults is an increase in activated circulating T follicular helper (cTfh) cells after vaccination. However, the imp
Externí odkaz:
https://doaj.org/article/f40a8c36fec04b7983ba1f4e01772959
Autor:
Eric Alves, Marwah Al-Kaabi, Niamh M Keane, Shay Leary, Coral-Ann M Almeida, Pooja Deshpande, Jennifer Currenti, Abha Chopra, Rita Smith, Alison Castley, Simon Mallal, Spyros A Kalams, Silvana Gaudieri, Mina John
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010965 (2022)
Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a major driver of human immunodeficiency virus (HIV) evolution at both the individual and population level. To date, there has been limited exploration of the impact of
Externí odkaz:
https://doaj.org/article/5b3936e98d094b46928ee18e598394bf
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/33e8f85ccdb54fb6839a033f11e28822
Autor:
Eric Alves, Shahama Taifour, Riccardo Dolcetti, Jonathan Chee, Anna K. Nowak, Silvana Gaudieri, Pilar Blancafort
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 592-606 (2021)
Precise clustered regularly interspaced short palindromic repeats (CRISPR)-mediated genetic and epigenetic manipulation of the immune response has become a promising immunotherapeutic approach toward combating tumorigenesis and tumor progression. CRI
Externí odkaz:
https://doaj.org/article/3cd97d3e8a124910bc080c62f88cdcb8
On the Evolutionary Trajectory of SARS-CoV-2: Host Immunity as a Driver of Adaptation in RNA Viruses
Autor:
Jacob Warger, Silvana Gaudieri
Publikováno v:
Viruses, Vol 15, Iss 1, p 70 (2022)
Host immunity can exert a complex array of selective pressures on a pathogen, which can drive highly mutable RNA viruses towards viral escape. The plasticity of a virus depends on its rate of mutation, as well as the balance of fitness cost and benef
Externí odkaz:
https://doaj.org/article/6677c587c5bb4a8db93568526bb99b3c
Autor:
Jennifer Currenti, Becker M.P. Law, Kai Qin, Mina John, Mark A. Pilkinton, Anju Bansal, Shay Leary, Ramesh Ram, Abha Chopra, Rama Gangula, Ling Yue, Christian Warren, Louise Barnett, Eric Alves, Wyatt J. McDonnell, Anuradha Sooda, Sonya L. Heath, Simon Mallal, Paul Goepfert, Spyros A. Kalams, Silvana Gaudieri
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another described, but less understood, adaptation strategy involves the selection of mutations with
Externí odkaz:
https://doaj.org/article/d451789591d94ef98727693bea82eac9
Autor:
Shelley Waters, Mark Agostino, Silvia Lee, Ibnu Ariyanto, Nina Kresoje, Shay Leary, Kylie Munyard, Silvana Gaudieri, Jessica Gaff, Ashley Irish, Anthony D. Keil, Patricia Price, Richard J. N. Allcock
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT Human cytomegalovirus (HCMV) is a beta-herpesvirus carried by ∼80% of the world’s population. Acute infections are asymptomatic in healthy individuals but generate diverse syndromes in neonates, solid organ transplant recipients, and HIV
Externí odkaz:
https://doaj.org/article/2695996f9dd54fd7acb7bbc9e9cec846
Autor:
Shay Leary, Silvana Gaudieri, Matthew Parker, Abha Chopra, Ian James, Suman Pakala, Eric Alves, Mina John, Benjamin Lindsey, Alexander Keeley, Sarah Rowland-Jones, Maurice Swanson, David Ostrov, Jodi Bubenik, Suman Das, John Sidney, Alessandro Sette, COVID-19 Genomics UK (COG-UK) consortium, Thushan de Silva, Elizabeth Phillips, Simon Mallal
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 2 (2021)
Background: Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host’s anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino
Externí odkaz:
https://doaj.org/article/0e6cb380ed5c485f8c8e44524bb4614b