Výsledky vyhledávání - "Silva Júnior, Eufrânio N. da"

Synthesis of selenium-quinone hybrid compounds with potential antitumor activity via Rh-Catalyzed C-H bond activation and click reactions

Autor: Jardim, Guilherme A. M., Cruz, Eduardo H. G. da, Valença, Wagner O., Lima, Daisy J. B., Cavalcanti, Bruno C., Pessoa, Claudia, Rafique, Jamal, Braga, Antonio L., Jacob, Claus, Silva Júnior, Eufrânio N. da

Publikováno v: Repositório Institucional da Universidade Federal do Ceará (UFC)
Universidade Federal do Ceará (UFC)
instacron:UFC

In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated agai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::5003282627a55dc48ae845f790d4c3a9
http://www.repositorio.ufc.br/handle/riufc/36061

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On the search for potential antimycobacterial drugs: synthesis of naphthoquinoidal, phenazinic and 1,2,3-triazolic compounds and evaluation against mycobacterium tuberculosis

Autor: Guilherme Jardim, Cruz, Eduardo H. G., Valença, Wagner O., Resende, Jarbas M., Rodrigues, Bernardo L., Ramos, Daniela F., Oliveira, Ronaldo N., Silva, Pedro E. A., Silva Júnior, Eufrânio N. Da

Publikováno v: Journal of the Brazilian Chemical Society v.26 n.5 2015
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 26, Issue: 5, Pages: 1013-1027, Published: MAY 2015
ResearcherID

Fifteen naphthoquinones, sixteen phenazines and fifteen aryl triazoles were synthesized and evaluated against Mycobacterium tuberculosis. Twenty five substances are reported here for the first time and, among all of the compounds evaluated, six prese

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::4f0a37a0ab320bada9f42dfbe09ae5f9
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532015000501013

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Anti-Trypanosoma cruzi compounds: our contribution for the evaluation and insights on the mode of action of naphthoquinones and derivatives

Autor: Silva Júnior, Eufrânio N. da, Jardim, Guilherme A. M., Menna-Barreto, Rubem F. S., Castro, Solange L. de

Publikováno v: Journal of the Brazilian Chemical Society v.25 n.10 2014
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 25, Issue: 10, Pages: 1780-1798, Published: OCT 2014

Chagas disease is caused by the parasite Trypanosoma cruzi and affects approximately eight million individuals in the developing world; it is also classified as a neglected tropical disease by the World Health Organization. The available therapy for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2be2215442794c2ede954e1b3bf94e02
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532014001000004

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Cytotoxic, trypanocidal activities and physicochemical parameters of nor-²-lapachone-based 1,2,3-triazoles

Autor: Silva Júnior, Eufrânio N. da, Moura, Maria Aline B. F. de, Pinto, Antonio V., Pinto, Maria do Carmo F. R., Souza, Maria Cecília B. V. de, Araújo, Ana J., Pessoa, Claudia, Costa-Lotufo, Letícia V., Montenegro, Raquel C., Moraes, Manoel Odorico de, Ferreira, Vitor F., Goulart, Marilia O. F.

Publikováno v: Journal of the Brazilian Chemical Society v.20 n.4 2009
Journal of the Brazilian Chemical Society
Sociedade Brasileira de Química (SBQ)
instacron:SBQ
Journal of the Brazilian Chemical Society, Volume: 20, Issue: 4, Pages: 635-643, Published: 2009

The cytotoxicities of five nor-²-lapachone-based 1,2,3-triazoles and the precursor azidonaphthoquinone were assayed against six neoplasic cancer cell lines: SF-295 (central nervous system), HCT-8 (colon), MDAMB-435 (melanoma), HL-60 (leukaemia), PC-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::2f94f8aa6f515dad90b7e4a2abda008d
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-50532009000400007

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