Trypanosoma cruzi synthesizes proline via a Δ¹-pyrroline-5-carboxylate reductase whose activity is fine-tuned by NADPH cytosolic pools.

Autor: Marchese, Letícia, Olavarria, Karel, Mantilla, Brian Suarez, Avila, Carla Cristi, Oliveira Souza, Rodolpho Ornitiz, Silva Damasceno, Flávia, Carolina Elias, Maria, Mariano Silber, Ariel

Publikováno v: Biochemical Journal; May2020, Vol. 477 Issue 10, p1827-1845, 19p

Pep5, a Fragment of Cyclin D2, Shows Antiparasitic Effects in Different Stages of the Trypanosoma cruzi Life Cycle and Blocks Parasite Infectivity.

Autor: de Araujo CB; Laboratório Especial de Ciclo Celular, Instituto Butantan, São Paulo, Brazil chris.biologia@gmail.com carolina.eliassabbaga@butantan.gov.br.; Center of Toxins, Immune Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil., de Lima LP; Laboratório Especial de Ciclo Celular, Instituto Butantan, São Paulo, Brazil.; Center of Toxins, Immune Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil., Calderano SG; Laboratório de Parasitologia, Instituto Butantan, São Paulo, Brazil., Silva Damasceno F; Laboratory of Biochemistry of Tryps (LaBTryps), Departamento de Parasitologia, Instituto de Ciências Biomédicas, São Paulo, Brazil., Silber AM; Laboratory of Biochemistry of Tryps (LaBTryps), Departamento de Parasitologia, Instituto de Ciências Biomédicas, São Paulo, Brazil., Elias MC; Laboratório Especial de Ciclo Celular, Instituto Butantan, São Paulo, Brazil chris.biologia@gmail.com carolina.eliassabbaga@butantan.gov.br.; Center of Toxins, Immune Response and Cell Signaling (CeTICS), Instituto Butantan, São Paulo, Brazil.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2019 Apr 25; Vol. 63 (5). Date of Electronic Publication: 2019 Apr 25 (Print Publication: 2019).