Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.

Autor: Li Q; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Hagberg CE; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.; Cardiovascular Medicine Division, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden., Silva Cascales H; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Lang S; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Hyvönen MT; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.; School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Salehzadeh F; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Chen P; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.; Center for Infectious Medicine, Department of Medicine, Karolinska Institute, Stockolm, Sweden., Alexandersson I; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Terezaki E; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Harms MJ; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Kutschke M; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden., Arifen N; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden., Krämer N; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Aouadi M; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.; Center for Infectious Medicine, Department of Medicine, Karolinska Institute, Stockolm, Sweden., Knibbe C; CarMeN Laboratory, Lyon University, INRIA, INSA Lyon, Lyon, France., Boucher J; Bioscience Metabolism, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.; The Lundberg Laboratory for Diabetes Research, University of Gothenburg, Gothenburg, Sweden.; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden., Thorell A; Department of Clinical Science, Danderyds Hospital, Karolinska Institutet and Department of Surgery, Ersta Hospital, Karolinska Institutet, Stockholm, Sweden., Spalding KL; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. kirsty.spalding@ki.se.; Karolinska Institutet/AstraZeneca Integrated Cardio Metabolic Centre (KI/AZ ICMC), Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. kirsty.spalding@ki.se.

Publikováno v: Nature medicine [Nat Med] 2021 Nov; Vol. 27 (11), pp. 1941-1953. Date of Electronic Publication: 2021 Oct 04.

Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1.

Autor: Silva Cascales H; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Burdova K; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic., Middleton A; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Kuzin V; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Müllers E; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Stoy H; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Baranello L; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Macurek L; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic., Lindqvist A; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden arne.lindqvist@ki.se.

Publikováno v: Life science alliance [Life Sci Alliance] 2021 Jan 05; Vol. 4 (3). Date of Electronic Publication: 2021 Jan 05 (Print Publication: 2021).

Targeting senescence‐associated secretory phenotypes to remodel the tumour microenvironment and modulate tumour outcomes.

Autor: Xiong, Jiaqiang¹ (AUTHOR), Dong, Lu² (AUTHOR), Lv, Qiongying¹ (AUTHOR), Yin, Yutong³ (AUTHOR), Zhao, Jiahui¹ (AUTHOR), Ke, Youning¹ (AUTHOR), Wang, Shixuan⁴ (AUTHOR) shixuanwang@tjh.tjmu.edu.cn, Zhang, Wei¹ (AUTHOR) zw6676@163.com, Wu, Meng⁴ (AUTHOR) mengwu@tjh.tjmu.edu.cn

Publikováno v: Clinical & Translational Medicine. Sep2024, Vol. 14 Issue 9, p1-25. 25p.

Preventing High Fat Diet-Induced Obesity and Related Hepatic Steatosis by Chlorin e6-Mediated Photodynamic Therapy.

Autor: Gurung, Pallavi¹ (AUTHOR) gp20@ds-pharm.co.kr, Lim, Junmo¹ (AUTHOR), Kim, Yong-Wan¹ (AUTHOR) thomas06@hanmail.net

Publikováno v: Pharmaceuticals (14248247). Jun2024, Vol. 17 Issue 6, p729. 15p.

Residual Cdk1/2 activity after DNA damage promotes senescence.

Autor: Müllers E; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Silva Cascales H; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden., Burdova K; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic., Macurek L; Laboratory of Cancer Cell Biology, Institute of Molecular Genetics, Academy of Sciences of the Czech Republic, Prague, Czech Republic., Lindqvist A; Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

Publikováno v: Aging cell [Aging Cell] 2017 Jun; Vol. 16 (3), pp. 575-584. Date of Electronic Publication: 2017 Mar 26.