Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease

Autor: Morabito, Samuel, Miyoshi, Emily, Michael, Neethu, Shahin, Saba, Martini, Alessandra Cadete, Head, Elizabeth, Silva, Justine, Leavy, Kelsey, Perez-Rosendahl, Mari, Swarup, Vivek

Publikováno v: Nature genetics, vol 53, iss 8

The gene-regulatory landscape of the brain is highly dynamic in health and disease, coordinating a menagerie of biological processes across distinct cell types. Here, we present a multi-omic single-nucleus study of 191,890 nuclei in late-stage Alzhei

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______325::1b6c707db7949d1a34db994a2db40e39
https://escholarship.org/uc/item/58r174d8

Single-nucleus multi-omics identifies shared and distinct pathways in Pick's and Alzheimer's disease.

Autor: Shi Z; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA., Das S; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA., Morabito S; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; Mathematical, Computational and Systems Biology Program, University of California, Irvine, CA 92697, USA., Miyoshi E; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA., Stocksdale J; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Department of Biological Chemistry, University of California, Irvine, CA 92697, USA., Emerson N; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA., Srinivasan SS; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; Mathematical, Computational and Systems Biology Program, University of California, Irvine, CA 92697, USA.; Department of Computer Science, University of California, Irvine, CA 92697, USA., Shahin A; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA., Rahimzadeh N; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Mathematical, Computational and Systems Biology Program, University of California, Irvine, CA 92697, USA., Cao Z; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA., Silva J; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA., Castaneda AA; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA., Head E; Department of Pathology and Laboratory Medicine, University of California, Irvine, CA 92697, USA., Thompson L; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA 92697, USA.; Department of Biological Chemistry, University of California, Irvine, CA 92697, USA., Swarup V; Department of Neurobiology and Behavior, Charlie Dunlop School of Biological Sciences, University of California, Irvine, CA 92697, USA.; Mathematical, Computational and Systems Biology Program, University of California, Irvine, CA 92697, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Sep 08. Date of Electronic Publication: 2024 Sep 08.

Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer's Disease.

Autor: Miyoshi E; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Morabito S; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.; Mathematical, Computational, and Systems Biology (MCSB) Program, University of California Irvine, Irvine, CA, USA.; Center for Complex Biological Systems (CCBS), University of California Irvine, Irvine, CA, USA., Henningfield CM; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Rahimzadeh N; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.; Mathematical, Computational, and Systems Biology (MCSB) Program, University of California Irvine, Irvine, CA, USA.; Center for Complex Biological Systems (CCBS), University of California Irvine, Irvine, CA, USA., Kiani Shabestari S; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA., Das S; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Michael N; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Reese F; Center for Complex Biological Systems (CCBS), University of California Irvine, Irvine, CA, USA.; Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA, USA., Shi Z; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Cao Z; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA., Scarfone V; Sue and Bill Gross Stem Cell Research Center, University of California Irvine, Irvine, CA, USA., Arreola MA; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Lu J; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA., Wright S; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Silva J; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Leavy K; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Lott IT; Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA, USA., Doran E; Department of Pediatrics, University of California Irvine School of Medicine, Orange, CA, USA., Yong WH; Department of Pathology and Laboratory Medicine, University of California Irvine , Irvine, CA, USA., Shahin S; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Perez-Rosendahl M; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, University of California Irvine , Irvine, CA, USA., Head E; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, University of California Irvine , Irvine, CA, USA., Green KN; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA., Swarup V; Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California Irvine, Irvine, CA, USA.; Center for Complex Biological Systems (CCBS), University of California Irvine, Irvine, CA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jul 26. Date of Electronic Publication: 2023 Jul 26.

Single-nucleus chromatin accessibility and transcriptomic characterization of Alzheimer's disease.

Autor: Morabito S; Mathematical, Computational and Systems Biology (MCSB) Program, University of California, Irvine, CA, USA.; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA., Miyoshi E; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Michael N; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Shahin S; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Martini AC; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA., Head E; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA., Silva J; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Leavy K; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA., Perez-Rosendahl M; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA.; Department of Pathology and Laboratory Medicine, University of California, Irvine, CA, USA., Swarup V; Institute for Memory Impairments and Neurological Disorders (MIND), University of California, Irvine, CA, USA. vswarup@uci.edu.; Department of Neurobiology and Behavior, University of California, Irvine, CA, USA. vswarup@uci.edu.

Publikováno v: Nature genetics [Nat Genet] 2021 Aug; Vol. 53 (8), pp. 1143-1155. Date of Electronic Publication: 2021 Jul 08.