Measuring cystic fibrosis drug responses in organoids derived from 2D differentiated nasal epithelia

Autor: Amatngalim, Gimano D, Rodenburg, Lisa W, Aalbers, Bente L, Raeven, Henriette Hm, Aarts, Ellen M, Sarhane, Dounia, Spelier, Sacha, Lefferts, Juliet W, Silva, Iris Al, Nijenhuis, Wilco, Vrendenbarg, Sacha, Kruisselbrink, Evelien, Brunsveld, Jesse E, van Drunen, Cornelis M, Michel, Sabine, de Winter-de Groot, Karin M, Heijerman, Harry G, Kapitein, Lukas C, Amaral, Magarida D, van der Ent, Cornelis K, Beekman, Jeffrey M, Celbiologie, Sub Cell Biology

Publikováno v: Life Science Alliance, 5(12):e202101320. Rockefeller University Press
Life Science Alliance, 5(12), 1. Rockefeller University Press

Cystic fibrosis is caused by genetic defects that impair the CFTR channel in airway epithelial cells. These defects may be overcome by specific CFTR modulating drugs, for which the efficacy can be predicted in a personalized manner using 3D nasal-bru

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f60e808fe15193a367ae894331f81c79
https://doi.org/10.26508/lsa.202101320

TMEM16A chloride channel does not drive mucus production.

Autor: Simões FB; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Quaresma MC; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Clarke LA; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Silva IA; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Pankonien I; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Railean V; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Kmit A; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal., Amaral MD; University of Lisboa, Faculty of Sciences, BioISI-Biosystems & Integrative Sciences Institute, Lisboa, Portugal mdamaral@fc.ul.pt.

Publikováno v: Life science alliance [Life Sci Alliance] 2019 Nov 15; Vol. 2 (6). Date of Electronic Publication: 2019 Nov 15 (Print Publication: 2019).