Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Silva, Hecimovic"'
Autor:
Fabiola De Marchi, Ivana Munitic, Lea Vidatic, Eliša Papić, Valentino Rački, Jerneja Nimac, Igor Jurak, Gabriela Novotni, Boris Rogelj, Vladimira Vuletic, Rajka M. Liscic, Jason R. Cannon, Emanuele Buratti, Letizia Mazzini, Silva Hecimovic
Publikováno v:
Biomedicines, Vol 11, Iss 10, p 2793 (2023)
Many potential immune therapeutic targets are similarly affected in adult-onset neurodegenerative diseases, such as Alzheimer’s (AD) disease, Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and frontotemporal dementia (FTD), as wel
Externí odkaz:
https://doaj.org/article/473fce8945424961988b168cd6f23534
Autor:
Fabiola De Marchi, Toni Franjkic, Paride Schito, Tommaso Russo, Jerneja Nimac, Anna A. Chami, Angelica Mele, Lea Vidatic, Jasna Kriz, Jean-Pierre Julien, Gordana Apic, Robert B. Russell, Boris Rogelj, Jason R. Cannon, Marco Baralle, Federica Agosta, Silva Hecimovic, Letizia Mazzini, Emanuele Buratti, Ivana Munitic
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1599 (2023)
Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative diseases. They also represent rare common events in an exceptionally broad landscape of genetic, environmental, neuropathologic, and clinical heterogeneity present in pat
Externí odkaz:
https://doaj.org/article/1d4499cfcc20462c9f6f60178f9f2d72
Autor:
Alessio Colombo, Lina Dinkel, Stephan A. Müller, Laura Sebastian Monasor, Martina Schifferer, Ludovico Cantuti-Castelvetri, Jasmin König, Lea Vidatic, Tatiana Bremova-Ertl, Andrew P. Lieberman, Silva Hecimovic, Mikael Simons, Stefan F. Lichtenthaler, Michael Strupp, Susanne A. Schneider, Sabina Tahirovic
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Niemann-Pick type C disease is a rare childhood neurodegenerative disorder predominantly caused by mutations in NPC1, resulting in abnormal late endosomal and lysosomal defects. Here the authors show that NPC1 disruption largely impairs microglial fu
Externí odkaz:
https://doaj.org/article/086477f8dbac4c818ed45236ab495029
Autor:
Lien Van Hoecke, Caroline Van Cauwenberghe, Kristina Dominko, Griet Van Imschoot, Elien Van Wonterghem, Jonas Castelein, Junhua Xie, Wouter Claeys, Charysse Vandendriessche, Anna Kremer, Peter Borghgraef, Riet De Rycke, Silva Hecimovic, Roosmarijn E. Vandenbroucke
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
Niemann-Pick type C (NPC) disease, sometimes called childhood Alzheimer’s, is a rare neurovisceral lipid storage disease with progressive neurodegeneration leading to premature death. The disease is caused by loss-of-function mutations in the Npc1
Externí odkaz:
https://doaj.org/article/eaa1ebe524ab48989b5697714ddd0bf0
Autor:
Kristina Dominko, Ana Rastija, Sandra Sobocanec, Lea Vidatic, Sarah Meglaj, Andrea Lovincic Babic, Birgit Hutter-Paier, Alessio-Vittorio Colombo, Stefan F. Lichtenthaler, Sabina Tahirovic, Silva Hecimovic
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 24, p 13256 (2021)
Niemann-Pick type C disease (NPC) is a rare inherited neurodegenerative disorder characterized by an accumulation of intracellular cholesterol within late endosomes and lysosomes due to NPC1 or NPC2 dysfunction. In this work, we tested the hypothesis
Externí odkaz:
https://doaj.org/article/67ca3503d20b48539006972a0277bafd
Autor:
Mirsada Causevic, Kristina Dominko, Martina Malnar, Lea Vidatic, Stjepko Cermak, Martina Pigoni, Peer-Hendrik Kuhn, Alessio Colombo, Daniel Havas, Stefanie Flunkert, Jessica McDonald, Jenny M Gunnersen, Birgit Hutter-Paier, Sabina Tahirovic, Manfred Windisch, Dimitri Krainc, Stefan F Lichtenthaler, Silva Hecimovic
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200344 (2018)
It is intriguing that a rare, inherited lysosomal storage disorder Niemann-Pick type C (NPC) shares similarities with Alzheimer's disease (AD). We have previously reported an enhanced processing of β-amyloid precursor protein (APP) by β-secretase (
Externí odkaz:
https://doaj.org/article/1789a778f74f4473b3cee534b11a03e1
Publikováno v:
Neurobiology of Disease, Vol 72, Iss , Pp 37-47 (2014)
Alzheimer's disease (AD) and Niemann–Pick type C (NPC) disease are progressive neurodegenerative diseases with very different epidemiology and etiology. AD is a common cause of dementia with a complex polyfactorial etiology, including both genetic
Externí odkaz:
https://doaj.org/article/c76fe41610c94ab79b4549b4ffdd5377
Autor:
Marko Kosicek, Silva Hecimovic
Publikováno v:
International Journal of Molecular Sciences, Vol 14, Iss 1, Pp 1310-1322 (2013)
Brain is one of the richest organs in lipid content. Phospholipids (glycerophospholipids and sphingolipids) are important building blocks of cell membranes, which provide an optimal environment for protein interactions, trafficking and function. Beca
Externí odkaz:
https://doaj.org/article/da352e21649f48ed8fbe8cb1ba5a61be
Autor:
Stjepko Cermak, Marko Kosicek, Aleksandra Mladenovic-Djordjevic, Kosara Smiljanic, Selma Kanazir, Silva Hecimovic
Publikováno v:
PLoS ONE, Vol 11, Iss 11, p e0167428 (2016)
Proper function of lysosomes is particularly important in neurons, as they cannot dilute accumulated toxic molecules and aggregates by cell division. Thus, impairment of lysosomal function plays an important role in neuronal degeneration and in the p
Externí odkaz:
https://doaj.org/article/5bb369c424eb4e27bb3ac841b1235402
Autor:
Kristina Dominko, Ana Rastija, Kosara Smiljanic, Aleksandra Mladenovic, Lucija Lešnjaković, Selma Kanazir, Desanka Milanovic, Silva Hecimovic
Publikováno v:
Mechanisms of Ageing and Development
The formation of amyloid-ß peptides (Aß), that accumulate in Alzheimer's disease (AD) brains, involves proteolytic processing of the amyloid precursor protein (APP) firstly by ß-secretase (BACE1). Since BACE1 cleaves a plethora of other substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b101dd6cf3005ba464cf75b12f866e
http://fulir.irb.hr/7675/7/MAD-D-22-00218_R1.pdf
http://fulir.irb.hr/7675/7/MAD-D-22-00218_R1.pdf
