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Bioinformatic analysis of the SPs and NFTs proteomes unravel putative biomarker candidates for Alzheimer's disease.

Autor: Ferreira MJC; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Soares Martins T; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Alves SR; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Rosa IM; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Vogelgsang J; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Georg-August University, Goettingen, Germany.; Translational Neuroscience Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA., Hansen N; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Georg-August University, Goettingen, Germany., Wiltfang J; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.; Department of Psychiatry and Psychotherapy, University Medical Center Goettingen (UMG), Georg-August University, Goettingen, Germany.; German Center for Neurodegenerative Diseases (DZNE), Goettingen, Germany., da Cruz E Silva OAB; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Vitorino R; Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal., Henriques AG; Neurosciences and Signaling Group, Department of Medical Sciences, Institute of Biomedicine (iBiMED), University of Aveiro, Aveiro, Portugal.

Publikováno v: Proteomics [Proteomics] 2023 Aug; Vol. 23 (15), pp. e2200515. Date of Electronic Publication: 2023 May 01.

High glucose‐mediated VPS26a down‐regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation.

Autor: Chae, Chang Woo¹ (AUTHOR), Choi, Gee Euhn¹ (AUTHOR), Jung, Young Hyun¹ (AUTHOR), Lim, Jae Ryong¹ (AUTHOR), Cho, Ji Hyeon¹ (AUTHOR), Yoon, Jee Hyeon¹ (AUTHOR), Han, Ho Jae¹ (AUTHOR) hjhan@snu.ac.kr

Publikováno v: British Journal of Pharmacology. Aug2022, Vol. 179 Issue 15, p3934-3950. 17p. 3 Color Photographs, 3 Graphs.

Gamma frequency light flicker regulates amyloid precursor protein trafficking for reducing β‐amyloid load in Alzheimer's disease model.

Autor: Shen, Qi^1,2 (AUTHOR), Wu, Xiaolei^1,2 (AUTHOR), Zhang, Zhan^1,2 (AUTHOR), Zhang, Di^1,2 (AUTHOR), Yang, Sihua^1,2 (AUTHOR) yangsh@scnu.edu.cn, Xing, Da^1,2 (AUTHOR) xingda@scnu.edu.cn

Publikováno v: Aging Cell. Mar2022, Vol. 21 Issue 3, p1-17. 17p.

"Amyloid‐beta accumulation cycle" as a prevention and/or therapy target for Alzheimer's disease.

Autor: Rao, Chinthalapally V.¹ (AUTHOR) cv-rao@ouhsc.edu, Asch, Adam S.² (AUTHOR), Carr, Daniel J. J.³ (AUTHOR), Yamada, Hiroshi Y.¹ (AUTHOR) Hiroshi-yamada@ouhsc.edu

Publikováno v: Aging Cell. Mar2020, Vol. 19 Issue 3, p1-24. 24p.