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Akademický článek

Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model

Autor: Alaa Alsalloum, Saleh Alrhmoun, Olga Perik-Zavosdkaia, Marina Fisher, Marina Volynets, Julia Lopatnikova, Roman Perik-Zavodskii, Julia Shevchenko, Julia Philippova, Olga Solovieva, Evgenii Zavjalov, Vasily Kurilin, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

The development of T cell receptor-engineered T cells (TCR-T) targeting intracellular antigens is a promising strategy for treating solid tumors; however, the mechanisms underlying their effectiveness remain poorly understood. In this study, we emplo

Externí odkaz: https://doaj.org/article/77dad727226247d3abacb18938ba3249

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Akademický článek

Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells

Autor: Sergey Sennikov, Marina Volynets, Saleh Alrhmoun, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Marina Fisher, Julia Lopatnikova, Julia Shevchenko, Kirill Nazarov, Julia Philippova, Alaa Alsalloum, Vasily Kurilin, Alexander Silkov

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

IntroductionAdoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested against a variety of blood neoplasms but is yet to be deeply tested against solid

Externí odkaz: https://doaj.org/article/433d45dbd46f482299d490a3b9a17848

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Akademický článek

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Akademický článek

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Akademický článek

Production of immunoregulatory molecules by induced erythroblasts at various stages of cell differentiation

Autor: K. V. Nazarov, R. Yu. Perik-Zavodsky, M. S. Kuznetsova, Yu. G. Philippova, Yu. A. Shevchenko, V. V. Denisova, A. N. Silkov, S. V. Sennikov

Publikováno v: Acta Biomedica Scientifica, Vol 7, Iss 5-1, Pp 179-187 (2022)

Introduction. Bone marrow erythroblasts produce a wide range of cytokines with opposite biological effects. This may be due to a change in the spectrum of production of immunoregulatory mediators during differentiation and small qualitative and quant

Externí odkaz: https://doaj.org/article/09db14e5ce904e3595ef437c406202e2

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Akademický článek

TCR-Engineered Lymphocytes Targeting NY-ESO-1: In Vitro Assessment of Cytotoxicity against Tumors

Autor: Alaa Alsalloum, Saleh Alrhmoun, Julia Shevchenko, Marina Fisher, Julia Philippova, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Julia Lopatnikova, Vasily Kurilin, Marina Volynets, Yasushi Akahori, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov

Publikováno v: Biomedicines, Vol 11, Iss 10, p 2805 (2023)

Adoptive T-cell therapies tailored for the treatment of solid tumors encounter intricate challenges, necessitating the meticulous selection of specific target antigens and the engineering of highly specific T-cell receptors (TCRs). This study delves

Externí odkaz: https://doaj.org/article/5093cd9ee41b46dc9ecc720514ddf6c1

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Akademický článek

EFFECT OF DNA CONSTRUCTIONS ELECTROPORATION ON DENDRITIC CELLS

Autor: A. S. Bulygin, V. P. Tereshchenko, R. Yu. Zavodskii, I. A. Obleukhova, S. V. Sennikov, A. N. Silkov

Publikováno v: Медицинская иммунология, Vol 23, Iss 4, Pp 653-658 (2021)

Today transfection of mammalian cell with DNA or RNA construction is the only method for delivering programmed information into the cell nucleus. Electroporation is most commonly used method of transfection in experiments with dendritic cell. The aim

Externí odkaz: https://doaj.org/article/8c5f64c187004a1aad527da9c86e420e

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Akademický článek

CO-EXPRESSION OF MEMBRANE-BOUND TUMOR NECROSIS FACTOR-α RECEPTORS IN MAJOR SUBPOPULATIONS OF IMMUNOCOMPETENT CELLS IN HEALTHY INDIVIDUALS AND PATIENTS WITH RHEUMATOID ARTHRITIS AS WELL AS BRONCHIAL ASTHMA

Autor: Yu. V. Zhukova, A. A. Alshevskaya, F. D. Kireev, O. A. Chumasova, N. S. Shkaruba, A. E. Sizikov, Yu. A. Lopatnikova, D. V. Demina, A. V. Karaulov, A. N. Silkov, S. V. Sennikov

Publikováno v: Медицинская иммунология, Vol 23, Iss 4, Pp 903-908 (2021)

A pleiotropic cytokine TNFα is an important inflammatory mediator of a number of diseases; its biological functions are fulfilled through two different receptors, TNFR1 and TNFR2. Changes in the ratio between these types of receptors shifting the ba

Externí odkaz: https://doaj.org/article/482fd1a256c14ef8b21598e321ea6907

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