Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Silke U. Oberdorf‐Maass"'
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Akademický článek
A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling
Autor: Kirsten T. Nijholt, Pablo I. Sánchez-Aguilera, Harmen G. Booij, Silke U. Oberdorf-Maass, Martin M. Dokter, Anouk H. G. Wolters, Ben N. G. Giepmans, Wiek H. van Gilst, Joan H. Brown, Rudolf A. de Boer, Herman H. W. Silljé, B. Daan Westenbrink
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract A Kinase Interacting Protein 1 (AKIP1) is a signalling adaptor that promotes physiological hypertrophy in vitro. The purpose of this study is to determine if AKIP1 promotes physiological cardiomyocyte hypertrophy in vivo. Therefore, adult ma
Externí odkaz: https://doaj.org/article/ed562cee66ed427ca8cecb89312bca87
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2
Akademický článek
Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation
Autor: Emmanouil Mavrogiannis, Quint A. J. Hagdorn, Venetia Bazioti, Johannes M. Douwes, Diederik E. Van Der Feen, Silke U. Oberdorf‐Maass, Marit Westerterp, Rolf M. F. Berger
Publikováno v: Pulmonary Circulation, Vol 12, Iss 3, Pp n/a-n/a (2022)
Abstract Pulmonary arterial hypertension (PAH) is a fatal disease characterized by increased pulmonary arterial pressure, inflammation, and neointimal remodeling of pulmonary arterioles. Serum levels of interleukin (IL)‐1β and IL‐18 are elevated
Externí odkaz: https://doaj.org/article/00ca98c48dea427ca494de673259cd0e
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3
Selenoprotein dio2 is a regulator of mitochondrial function, morphology and uprmt in human cardiomyocytes
Autor: Eugene Berezikov, Annet N. Linders, Herman H W Silljé, Peter van der Meer, Warner S. Simonides, Frederik E. Deiman, B. Daan Westenbrink, Mario G. Pavez-Giani, Nils Bomer, Martijn F Hoes, Silke U. Oberdorf-Maass, Christiane L.J. Baierl, Rudolf A. de Boer
Publikováno v: Bomer, N, Pavez-giani, M G, Deiman, F E, Linders, A N, Hoes, M F, Baierl, C L J, Oberdorf-maass, S U, de Boer, R A, Silljé, H H W, Berezikov, E, Simonides, W S, Westenbrink, B D & van der Meer, P 2021, ' Selenoprotein dio2 is a regulator of mitochondrial function, morphology and uprmt in human cardiomyocytes ', International Journal of Molecular Sciences, vol. 22, no. 21, 11906 . https://doi.org/10.3390/ijms222111906
International Journal of Molecular Sciences
Volume 22
Issue 21
International Journal of Molecular Sciences, 22(21):11906. Multidisciplinary Digital Publishing Institute (MDPI)
International Journal of Molecular Sciences, 22(21):11906. MDPI AG
International Journal of Molecular Sciences, Vol 22, Iss 11906, p 11906 (2021)
Members of the fetal-gene-program may act as regulatory components to impede deleterious events occurring with cardiac remodeling, and constitute potential novel therapeutic heart failure (HF) targets. Mitochondrial energy derangements occur both dur
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f72cfa7c338770407ee75ff06bb0628
https://research.vumc.nl/en/publications/d31b9c3e-7ffb-4dff-895c-e03d9b035c1b
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4
ATPase Inhibitory Factor-1 Disrupts Mitochondrial Ca2+ Handling and Promotes Pathological Cardiac Hypertrophy through CaMKIIδ
Autor: Harmen G Booij, Mario G. Pavez-Giani, Salva R. Yurista, B. Daan Westenbrink, Silke U. Oberdorf-Maass, Joan Heller Brown, Nils Bomer, Hendrik Milting, Shigeki Miyamoto, Rudolf A. de Boer, Peter van der Meer, Herman W H Sillje, Paula Giraldo, Pablo I Sánchez-Aguilera, Kirsten T Nijholt
Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences, Vol 22, Iss 4427, p 4427 (2021)
International Journal of Molecular Sciences, 22(9), 1-20. MDPI AG
ATPase inhibitory factor-1 (IF1) preserves cellular ATP under conditions of respiratory collapse, yet the function of IF1 under normal respiring conditions is unresolved. We tested the hypothesis that IF1 promotes mitochondrial dysfunction and pathol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cddb032f79f13e2d3881ee104d2020c2
http://europepmc.org/articles/PMC8122940
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5
DIO2 Is a Regulator of Mitochondrial Function, Morphology and UPR mt in Human Cardiomyocytes
Autor: Warner S. Simonides, Frederik E. Deiman, Annet N. Linders, Rudolf A. de Boer, B. Daan Westenbrink, Herman H W Silljé, Mario G. Pavez-Giani, Silke U. Oberdorf-Maass, Martijn F Hoes, Peter van der Meer, Eugene Berezikov, Christiane L.J. Baierl, Nils Bomer
Publikováno v: SSRN Electronic Journal.
Objectives: To elucidate the role of DIO2, member of the fetal-gene-program, in PSC-derived human cardiomyocytes and on mitochondrial dynamics and energetics, specifically. Background: Members of the fetal-gene-program may act as regulatory component
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8219739225e49fffd1302f9bcd5433fc
https://doi.org/10.2139/ssrn.3891284
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6
Effects of Sodium-Glucose Co-transporter 2 Inhibition with Empaglifozin on Renal Structure and Function in Non-diabetic Rats with Left Ventricular Dysfunction After Myocardial Infarction
Autor: Rudolf A. de Boer, Salva R. Yurista, Harry van Goor, Silke U. Oberdorf-Maass, Jan-Luuk Hillebrands, Hiddo J.L. Heerspink, Herman H W Silljé, B. Daan Westenbrink, Luiz de Menezes Montenegro
Publikováno v: Cardiovascular Drugs and Therapy, 34(3), 311-321. SPRINGER
Cardiovascular Drugs and Therapy
Background The use of sodium–glucose co-transporter 2 inhibitors (SGLT2i) is currently expanding to cardiovascular risk reduction in non-diabetic subjects, but renal (side-)effects are less well studied in this setting. Methods Male non-diabetic Sp
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43453eb163e61eb188dbeb3254b8a84f
https://research.rug.nl/en/publications/733c8ffe-c877-4d08-b761-d6103b3925b0
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7
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties
Autor: Peter van der Meer, Chim C. Lang, Stefan D. Anker, Dirk J. van Veldhuisen, Jasper Tromp, Nilesh J. Samani, Nils Bomer, Martijn F Hoes, Hans L. Hillege, Marco Metra, Leong L. Ng, Silke U. Oberdorf-Maass, Wouter Ouwerkerk, Pim van der Harst, Adriaan A. Voors
Publikováno v: European journal of heart failure, 22(11), 2102-2111. Wiley-Blackwell
European Journal of Heart Failure. Wiley
European Journal of Heart Failure
AIMS: Cathepsin D is a ubiquitous lysosomal protease that is primarily secreted due to oxidative stress. The role of circulating cathepsin D in heart failure (HF) is unknown. The aim of this study is to determine the association between circulating c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcc5a3ff20612e2dd2c80e8f019a138d
https://doi.org/10.1002/ejhf.1674
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8
Sodium-glucose co-transporter 2 inhibition with empagliflozin improves cardiac function in non-diabetic rats with left ventricular dysfunction after myocardial infarction
Autor: Mario G Pavez Giani, Jan-Luuk Hillebrands, Silke U. Oberdorf-Maass, Dirk J. van Veldhuisen, Harry van Goor, Herman H W Silljé, Salva R. Yurista, Rudolf A. de Boer, Elisabeth-Maria Schouten, B. Daan Westenbrink
Publikováno v: European Journal of Heart Failure, 21(7), 862-873. Wiley
AIMS: Sodium-glucose co-transporter 2 (SGLT2) inhibition reduces heart failure hospitalizations in patients with diabetes, irrespective of glycaemic control. We examined the effect of SGLT2 inhibition with empagliflozin (EMPA) on cardiac function in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf8d7c03bf9e36dd5e27ef425701b6b
https://pubmed.ncbi.nlm.nih.gov/31112012
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9
Cyclical stretch induces structural changes in atrial myocytes
Autor: Alexander H. Maass, Wiek H. van Gilst, Anne Margreet De Jong, Rudolf A. de Boer, Isabelle C. Van Gelder, Silke U. Oberdorf-Maass
Publikováno v: Journal of Cellular and Molecular Medicine
Journal of cellular and molecular medicine, 17(6), 743-753. Wiley
Atrial fibrillation (AF) often occurs in the presence of an underlying disease. These underlying diseases cause atrial remodelling, which make the atria more susceptible to AF. Stretch is an important mediator in the remodelling process. The aim of t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7655458a569105196bcdc8258310b557
https://research.rug.nl/en/publications/9fa6aed9-8912-4e5e-b94a-c314cf792079
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10
Mechanisms of atrial structural changes caused by stretch occurring before and during early atrial fibrillation
Autor: Anne-Margreet R. De Jong, Wiek H. van Gilst, Silke U. Oberdorf-Maass, Dirk J. van Veldhuisen, Alexander H. Maass, Isabelle C. Van Gelder
Publikováno v: Cardiovascular research. 89(4)
Structural remodelling occurring before, due to the underlying heart disease, and during atrial fibrillation (AF) sets the stage for permanent AF. Current therapy in AF aims to maintain sinus rhythm in symptomatic patients, but outcome is unfortunate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2346437b9e72ab6e1c298f864d4cacb
https://pubmed.ncbi.nlm.nih.gov/21075756
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