Myelin-derived lipids modulate macrophage activity by liver X receptor activation.

Autor: Jeroen F J Bogie, Silke Timmermans, Vân Anh Huynh-Thu, Alexandre Irrthum, Hubert J M Smeets, Jan-Åke Gustafsson, Knut R Steffensen, Monique Mulder, Piet Stinissen, Niels Hellings, Jerome J A Hendriks

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e44998 (2012)

Multiple sclerosis is a chronic, inflammatory, demyelinating disease of the central nervous system in which macrophages and microglia play a central role. Foamy macrophages and microglia, containing degenerated myelin, are abundantly found in active

Externí odkaz: https://doaj.org/article/5aafb65e5a5b4dbea6049ae2cc79c7b5

Low-density lipoprotein receptor deficiency attenuates neuroinflammation through the induction of apolipoprotein E

Autor: Jasmine Vanmol, Silke Timmermans, Jo Mailleux, Jerome J. A. Hendriks, Jeroen F. J. Bogie, Tim Vanmierlo, Katherine Nelissen, Jack van Horssen

Publikováno v: Frontiers in Immunology, 8(NOV):1701. Frontiers Media S.A.
Mailleux, J, Timmermans, S, Nelissen, K, Vanmol, J, Vanmierlo, T, van Horssen, J, Bogie, J F J & Hendriks, J J A 2017, ' Low-density lipoprotein receptor deficiency attenuates neuroinflammation through the induction of apolipoprotein E ', Frontiers in Immunology, vol. 8, no. NOV, 1701 . https://doi.org/10.3389/fimmu.2017.01701
Frontiers in Immunology, Vol 8 (2017)
Frontiers in Immunology

Objective: We aimed to determine the role of the low-density lipoprotein receptor (LDLr) in neuroinflammation by inducing experimental autoimmune encephalomyelitis (EAE) in ldlr knock out mice. Methods: MOG35–55 induced EAE in male and female ldlr�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7145fa33d57167d8db8798fabf9cab79
https://doi.org/10.3389/fimmu.2017.01701

Block of a subset of sodium channels exacerbates experimental autoimmune encephalomyelitis

Autor: Myriam Baes, Silke Timmermans, Jerome J. A. Hendriks, Jan Tytgat, Astrid Bottelbergs, Marijke Stevens, Bert Brône

Publikováno v: Journal of Neuroimmunology. 261:21-28

Voltage-gated sodium channels (Navs) are involved in several aspects of the pathogenesis of multiple sclerosis (MS). Within acute MS plaques, they are expressed along demyelinated axons. Studies in experimental autoimmune encephalomyelitis (EAE) demo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbbb6d4ec2f8f0bb05eca2f9d6142f8
https://doi.org/10.1016/j.jneuroim.2013.04.012

Selective identification of macrophages and cancer cells based on thermal transport through surface-imprinted polymer layers

Autor: Jeroen F. J. Bogie, Kasper Eersels, Patrick Wagner, Veerle Somers, Silke Timmermans, Kathia L. Jiménez Monroy, Thomas J. Cleij, Thijs Vandenryt, Ward De Ceuninck, Anitha Ethirajan, Bart van Grinsven, Sathya Punniyakoti, Jerome J. A. Hendriks, Mat J.A.P. Daemen

Publikováno v: ACS applied materials & interfaces, 5(15), 7258-7267. American Chemical Society
ACS Applied Materials & Interfaces, 5(15), 7258-7267. American Chemical Society

In this article, we describe a novel straightforward method for the specific identification of viable cells (macrophages and cancer cell lines MCF-7 and Jurkat) in a buffer solution. The detection of the various cell types is based on changes of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07c23c2338daa2fb3d8b9b167470492
https://pubmed.ncbi.nlm.nih.gov/23820628

Liver X receptors regulate cholesterol homeostasis in oligodendrocytes

Autor: Silke Timmermans, Marcel Ameloot, Ilse Smets, Jerome J. A. Hendriks, Karen Smeets, Monique T. Mulder, Katherine Nelissen

Publikováno v: ResearcherID
Journal of Neuroscience Research, 90(1), 60-71. Wiley-Liss Inc.

Cholesterol synthesis and transport in oligodendrocytes are essential for optimal myelination and remyelination in pathological conditions such as multiple sclerosis. However, little is known about cholesterol homeostasis in the myelin-forming oligod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::745b6a43ae579a9bcea9331fe4991de9
https://pubmed.ncbi.nlm.nih.gov/21972082